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This medication comes with important safety warnings that highlight potential risks and precautions necessary for safe use. Please review them carefully and consult your healthcare provider if you have any questions or concerns.

• Kidney Issues: Some individuals may experience kidney problems, including the formation of kidney stones or more severe kidney damage, potentially leading to kidney failure. The risk is heightened for those with a history of kidney conditions or those using other kidney-impacting medications like NSAIDs (e.g., ibuprofen). Inform your healthcare provider about your medical history and all medications you are taking.

• Acute Intolerance Syndrome: Mesalamine can cause a rare abnormal reaction known as acute intolerance syndrome, which can mimic a UC flare-up. Symptoms include stomach cramping, bloody diarrhea, and occasionally fever, headache, and rash. Notify your healthcare provider if these symptoms arise, as discontinuing mesalamine may be necessary.

• Liver Concerns: Although rare, mesalamine can lead to liver issues, including liver failure in individuals with pre-existing liver conditions. Report any signs of liver problems, such as yellowing of the skin or eyes, dark urine, fatigue, or right-sided stomach pain, to your provider immediately.

• Allergic and Severe Skin Reactions: Infrequent but serious allergic reactions may occur, potentially affecting breathing, causing severe rashes, or impacting organs like the heart, liver, or kidneys. Seek immediate medical attention if you experience symptoms like itching, hives, shortness of breath, chest tightness, or swelling of the lips, tongue, face, or eyes.

• Iron Content: Some mesalamine tablets and capsules contain iron oxide. Discuss with your healthcare provider if you are taking iron supplements or have conditions that increase your risk of iron overload to prevent harmful effects.

• Phenylketonuria (PKU) Caution: Apriso extended-release capsules contain phenylalanine, which can be harmful to individuals with PKU. If you have PKU, your healthcare provider can recommend a safer alternative.

Contraindications: This medication should not be used if you are allergic to aspirin or other salicylates. If this applies to you, consult your healthcare provider before starting treatment.

When taking this medication, some common side effects may include headache, stomach pain, nausea, diarrhea, indigestion, belching, loss of appetite, constipation, vomiting, gas, dizziness, back pain, rash, and symptoms of a common cold or upper respiratory infection. These are usually mild, but if they persist or worsen, consulting a healthcare provider is advised.

Rarely, this medication can exacerbate ulcerative colitis, leading to increased abdominal pain, cramping, and bloody diarrhea. It is crucial to contact a healthcare provider if these symptoms appear. Serious side effects, though uncommon, require immediate medical attention. These include signs of kidney problems such as trouble urinating, changes in urine output, blood in urine, back or side pain, fever, and chills. Signs of liver issues, like yellowing of the skin or eyes, dark urine, severe stomach pain, and fatigue, should also prompt urgent care.

Allergic reactions to this medication are rare but serious, with symptoms including fever, swollen lymph nodes, rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing. Severe skin reactions, such as hives, discolored patches, peeling skin, or blisters, may occur with or without fever or body aches. If any of these serious symptoms develop, seek medical help immediately. Remember, this is not a complete list of side effects, and for any other concerns, contacting a healthcare provider is recommended.

Mesalamine should not be taken with Balsalazide, olsalazine, or Sulfasalazine, as they are very similar and could lead to adverse interactions. Additionally, mesalamine may affect certain laboratory tests, particularly urine normetanephrine levels, potentially resulting in inaccurate results. It is important for lab personnel and healthcare providers to be informed that you are using mesalamine to prevent any misinterpretation of test outcomes.

Moreover, mesalamine might interact with a wide range of medications. It is crucial to inform your doctor and pharmacist about all medications and supplements you are currently taking, including prescriptions, over-the-counter drugs, vitamins, and herbal products. Some specific medications that may interact with mesalamine and are typically not recommended unless necessary include Aceclofenac, Acemetacin, Amtolmetin Guacil, and many others in the anti-inflammatory and salicylate categories. If these medicines are prescribed together, your doctor may adjust the dosage or frequency of use to ensure safety.

There are also medications like Tamarind and Warfarin that, when used with mesalamine, could increase the risk of side effects. However, the combination might still be considered if it offers the best treatment option for you. In such cases, your healthcare provider may modify how you take these medications to minimize risks. Always consult your healthcare provider before starting or stopping any medication while on mesalamine.