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You might experience headaches or abdominal pain while using this medication. These are common side effects and usually mild, but if they persist or worsen, it is important to consult your healthcare provider. Although many individuals do not experience serious side effects, be aware that mesalamine can sometimes aggravate ulcerative colitis. If you notice increased abdominal pain, cramping, or bloody diarrhea, seek medical advice immediately.

There are some serious side effects to watch for, such as persistent nausea or vomiting, signs of kidney issues (like changes in urine or blood in the urine), dark urine, intense stomach or abdominal pain, yellowing of the eyes or skin, chest pain, or shortness of breath. These require prompt medical attention.

While a severe allergic reaction to this medication is rare, it is crucial to seek emergency help if you experience symptoms like fever, swollen lymph nodes, rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing.

This summary does not cover all possible side effects. If you experience any unusual symptoms not mentioned here, contact your healthcare provider for advice.