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Sulfasalazine

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Sulfasalazine is used to treat a certain type of bowel disease called ulcerative colitis. This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. This medication works by reducing irritation and swelling in the large intestines. In addition, delayed-release tablets of sulfasalazine are used to treat rheumatoid arthritis. Sulfasalazine helps to reduce joint pain, swelling, and stiffness. Early treatment of rheumatoid arthritis with sulfasalazine helps to reduce/prevent further joint damage so you can do more of your normal daily activities. This medication is used with other drugs, rest, and physical therapy in patients who have not responded to other medications (salicylates, nonsteroidal anti-inflammatory drugs-NSAIDs).
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500MG, Sulfasalazine (30 Tablets)

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CVS

$23.19

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$7.37

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$8.49

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$14.19

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Sulfasalazine Side Effects

Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. This medication may cause your skin and urine to turn orange-yellow. This effect is harmless and will disappear when the medication is stopped. Rarely, delayed-release tablets of sulfasalazine may appear whole or only partly dissolved in your stool. If this occurs, tell your doctor right away so your treatment can be changed. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: hearing changes (such as ringing in the ears), mental/mood changes, signs of kidney problems (such as change in the amount of urine, painful urination, blood in the urine), new lump/growth in the neck (goiter), numbness/tingling of the hands/feet, signs of low blood sugar (such as hunger, cold sweat, blurred vision, weakness, fast heartbeat). This medication may rarely cause very serious allergic reactions (such as Stevens-Johnson syndrome), blood disorders (such as agranulocytosis, aplastic anemia), liver damage, nerve/muscle problems and infections. Get medical help right away if you have any very serious side effects, including: headache that is severe or doesn't go away, skin rash/blisters/peeling, mouth sores, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, chest pain, signs of infection (such as sore throat that doesn't go away, fever, chills, cough), swollen lymph nodes, easy bruising/bleeding, severe tiredness, muscle pain/weakness (especially with fever and unusual tiredness), pale or blue skin/lips/nails, new/worsening joint pain, confusion, unexplained neck stiffness, seizures, signs of liver problems (such as nausea/vomiting that doesn't stop, severe stomach/abdominal pain, yellowing eyes/skin, dark urine). This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Some products that may interact with this drug include: digoxin, folic acid, methenamine, PABA taken by mouth. Sulfasalazine is very similar to mesalamine. Do not use mesalamine medications taken by mouth while using sulfasalazine. This medication may interfere with certain lab tests (such as urine normetanephrine levels, liver function tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
Sulfasalazine FAQs
What is the drug sulfasalazine used for?

Sulfasalazine is used to treat inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. It is also used to manage rheumatoid arthritis. The drug works by reducing inflammation in the body.

Sulfasalazine is not being universally discontinued. However, there may be specific reasons for its discontinuation in certain cases, such as individual patient intolerance, adverse effects, or the availability of more effective treatments for specific conditions. It is important for patients to consult with their healthcare provider to understand the specific reasons for any changes in their medication regimen.

Sulfasalazine is not commonly associated with weight gain as a side effect. However, individuals may experience different reactions to medications. If there are concerns about weight changes while taking sulfasalazine, it is advisable to consult with a healthcare provider for personalized advice and evaluation.

Sulfasalazine may interact with several medications. It is important to avoid taking it with:1. Methotrexate: This combination can increase the risk of liver damage.2. Warfarin: Sulfasalazine can enhance the effects of warfarin, increasing the risk of bleeding.3. Digoxin: Sulfasalazine may reduce the absorption and effectiveness of digoxin.4. Folic Acid: Sulfasalazine can interfere with the absorption of folic acid, potentially leading to deficiency.5. Antibiotics: Some antibiotics may reduce the effectiveness of sulfasalazine.Patients should always consult with their healthcare provider before starting or stopping any medications to ensure safety and efficacy.

Yes, sulfasalazine can help alleviate joint pain. It is commonly used as a disease-modifying antirheumatic drug (DMARD) to treat inflammatory conditions such as rheumatoid arthritis. It works by reducing inflammation, which can help decrease joint pain and swelling. However, it may take several weeks to notice an improvement in symptoms. It is important for patients to follow their healthcare provider's instructions and discuss any concerns or side effects with them.

When taking sulfasalazine, several precautions should be considered:1. Allergies: Patients should inform their healthcare provider about any allergies, especially to sulfa drugs, aspirin, or other medications.2. Medical History: It's important to discuss any history of liver or kidney disease, blood disorders, asthma, or intestinal blockage with a healthcare provider.3. Pregnancy and Breastfeeding: Patients should inform their doctor if they are pregnant, planning to become pregnant, or breastfeeding, as sulfasalazine can affect the baby.4. Regular Monitoring: Regular blood tests may be required to monitor blood cell counts and liver function.5. Hydration: Adequate fluid intake is recommended to prevent kidney stones.6. Sun Sensitivity: Sulfasalazine can increase sensitivity to sunlight, so using sunscreen and wearing protective clothing is advised.7. Medication Interactions: Patients should inform their healthcare provider about all other medications they are taking to avoid potential interactions.8. Side Effects: Be aware of potential side effects such as nausea, headache, or rash, and report any severe or unusual symptoms to a healthcare provider promptly. Following these precautions can help manage the treatment effectively and minimize potential risks.

The safety of methotrexate versus sulfasalazine depends on the individual patient's condition, medical history, and specific health needs. Both medications have potential side effects and risks. Methotrexate can affect liver function and blood cell counts, and may cause gastrointestinal issues. Sulfasalazine can cause gastrointestinal disturbances and may affect liver function and blood cell counts as well. It is important for a healthcare provider to evaluate the patient's overall health and treatment goals to determine which medication is safer for their specific situation. Regular monitoring and follow-up are essential when using either medication.

Sulfasalazine can cause gastrointestinal side effects in some individuals, which may include diarrhea or increased bowel movements. If someone experiences significant changes in bowel habits while taking sulfasalazine, it is advisable to consult a healthcare provider.

When taking sulfasalazine, it is important to avoid the following:1. Alcohol: It may increase the risk of liver damage.2. Sunlight: Sulfasalazine can make the skin more sensitive to sunlight, so it's advisable to use sunscreen and wear protective clothing.3. Certain Medications: Avoid taking other medications that can affect the liver or kidneys without consulting a healthcare provider.4. Dehydration: Ensure adequate fluid intake to prevent kidney stones.5. Antacids: They may interfere with the absorption of sulfasalazine.Patients should always consult their healthcare provider for personalized advice and before making any changes to their medication regimen.

Yes, vitamin D can generally be taken with sulfasalazine. There are no known significant interactions between these two substances. However, it is always advisable for individuals to consult with their healthcare provider before starting any new supplements or medications to ensure it is appropriate for their specific health needs.

Yes, it is generally safe to take Tylenol (acetaminophen) while taking sulfasalazine. There are no known direct interactions between these two medications. However, it is always advisable to consult with a healthcare provider before combining medications to ensure it is appropriate for the individual's specific health situation.