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This drug safety information highlights critical warnings and contraindications associated with the use of sulfasalazine (Azulfidine). It is essential to review these details thoroughly and discuss any concerns with your healthcare provider to ensure safe usage.

• Liver, Kidney, and Blood Risks: Individuals using sulfasalazine (Azulfidine) may experience serious health issues affecting the liver, kidneys, or blood. These complications can be life-threatening in rare cases. If you have a history of liver damage, kidney problems, or blood disorders, inform your healthcare provider. Also, individuals with glucose-6 phosphate dehydrogenase deficiency (G6PD deficiency) should exercise caution.

• Impact on Sperm Count: Sulfasalazine (Azulfidine) may reduce sperm count, potentially affecting fertility. This side effect is typically reversible upon discontinuation of the medication. Discuss family planning and alternative anti-inflammatory treatments with your provider if this is a concern.

• Risk of Serious Infections: The use of sulfasalazine (Azulfidine) has been linked to severe infections such as pneumonia and bloodstream infections. Your healthcare provider will monitor for signs of infection during treatment. Notify them immediately if you experience symptoms like fever, chills, sweating, difficulty breathing, nausea, vomiting, or general weakness. Those with a history of recurrent infections, on immunosuppressants, or with weakened immune systems should be particularly cautious.

• Severe Skin and Allergic Reactions: This medication may cause severe skin reactions, including rashes, which can sometimes require hospitalization. The risk is heightened for individuals allergic to sulfasalazine, sulfa drugs, or salicylates like aspirin. Seek urgent medical attention if you encounter symptoms such as rash, blistering, peeling skin, facial sores, swelling, or breathing difficulties.

Contraindications: Avoid using sulfasalazine (Azulfidine) if you have any of the following conditions, as they may lead to serious health complications:

• Blockage in the gut or bladder.
• Porphyria, a liver disorder causing porphyrin accumulation.
• Known allergies to sulfasalazine, sulfa drugs, or salicylates.

Consult your healthcare provider for further guidance if any contraindications apply to you.

Common side effects:

• nausea
• vomiting
• stomach upset
• loss of appetite
• headache
• dizziness
• unusual tiredness
• indigestion
• fever
• mild stomach pain

Less common but important to monitor:

• medication appearing undissolved in stool
• hearing changes
• mental or mood alterations
• signs of kidney issues
• low blood sugar symptoms

Serious side effects:

• severe allergic reactions
• blood disorders
• liver damage
• nerve or muscle problems
• severe headache
• skin rash or blisters
• mouth sores
• swelling
• severe dizziness
• trouble breathing
• signs of infection
• signs of liver problems
• unexplained physical changes such as new lumps or growths

Interactions with high risk of serious adverse effects and should be avoided:

• Methenamine
• Ketorolac

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Mesalamine
• Aceclofenac
• Amoxicillin
• Azathioprine
• Ibuprofen
• Naproxen

Interactions with low risk that usually do not require a change in therapy:

• Aminolevulinic Acid
• Cyclosporine
• Digoxin
• Eltrombopag
• Warfarin