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Balsalazide

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generic Colazal

Balsalazide, also known by its brand name Colazal, is a medication belonging to the aminosalicylate class. It is commonly prescribed to manage mild-to-moderate ulcerative colitis in individuals aged 5 years and older. This drug works by reducing inflammation in the colon, thereby alleviating symptoms such as diarrhea, rectal bleeding, and stomach pain. Balsalazide functions by blocking the production of inflammatory proteins and chemicals in the gut, which helps decrease swelling. It is typically administered in 750 mg capsules, with the standard adult dosage being three capsules taken orally three times a day, while children may take one to three capsules as required. Common side effects include stomach pain and diarrhea. Always consult a healthcare professional before starting any new medication.
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Balsalazide WarningsBalsalazide Side EffectsBalsalazide InteractionsFAQs

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750MG, Balsalazide (30 Capsules)

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CVS

$24.72

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$10.48

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$15.94

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$16.08

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Balsalazide dosage forms

The average cost for 30 Capsules of Balsalazide (generic Colazal) at 750MG is $10.48 with a free coupon. This is 21.01% off the average retail price of $49.89
DosageQuantityPrice fromPer unit
750MG30 Capsules$10.48$0.35

Balsalazide Warnings

This document outlines important safety and warning information for the use of balsalazide (Colazal). Please review these details carefully and consult your healthcare provider if you have any questions or concerns.

  • Kidney Damage: Balsalazide may cause kidney damage, especially in individuals with pre-existing kidney issues or those using medications harmful to the kidneys, such as NSAIDs or diuretics.

  • Kidney Stones: There is a risk of developing kidney stones while on balsalazide. To minimize this risk, ensure adequate daily hydration. Contact your healthcare provider if you experience difficulty urinating, changes in urination, blood in urine, or back/side pain.

  • Acute Intolerance Syndrome: Rarely, balsalazide can cause an acute intolerance syndrome, typically occurring 1 to 3 weeks after starting the medication. Symptoms generally subside after discontinuing the drug or starting corticosteroids.

  • Allergic Reactions: Severe allergic reactions, including anaphylaxis, are possible. Seek emergency medical attention if you develop hives, rash, swelling of the lips or tongue, or breathing difficulties. Increased risk exists for those allergic to sulfasalazine or other aminosalicylates/salicylates.

  • Severe Skin Reactions: Rare but serious skin reactions like Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or DRESS syndrome may occur.

  • Liver Problems: Although uncommon, individuals with liver issues have developed liver failure after using mesalamine, a drug similar to balsalazide. Inform your healthcare provider of any liver history to assess treatment risks versus benefits.

  • Sun Sensitivity: Patients with skin conditions such as eczema may experience increased sun sensitivity, leading to easier sunburns.

  • Gut Blockage Caution: Balsalazide should be avoided in individuals with bowel obstructions as it may delay medication efficacy. Report symptoms like severe stomach cramping, pain, vomiting, constipation, or a swollen belly to your doctor.

Contraindications: Do not use balsalazide if you have allergies to aspirin or other salicylates, including mesalamine and sulfasalazine. Consult your healthcare provider if these conditions apply to you.

Balsalazide Side Effects

Common side effects:

  • Stomach pain
  • Diarrhea
  • Joint pain
  • Loss of appetite
  • Passing gas
  • Indigestion
  • Stuffy or runny nose
  • Sore throat
  • Cough
  • Trouble sleeping
  • Tiredness
  • Fever

Serious side effects:

  • Exacerbation of ulcerative colitis
  • Increased abdominal pain
  • Rectal bleeding
  • Signs of kidney issues (reduced urination, dry and itchy skin, swelling in extremities)
  • Symptoms of kidney stones (trouble urinating, bloody urine)
  • Liver problems (yellowing of skin or eyes, stomach bloating, dark urine)
  • Serious skin reactions (hives, blisters, peeling skin)
  • Serious allergic reaction (swelling of lips or tongue, difficulty breathing)

Balsalazide Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

Balsalazide FAQs
What is balsalazide used for?

Balsalazide is used to treat mild to moderate ulcerative colitis, which is an inflammatory bowel disease affecting the colon and rectum. It helps to reduce symptoms such as diarrhea, rectal bleeding, and stomach pain by decreasing inflammation in the colon.

Drugs that are comparable to mesalamine, which is used to treat inflammatory bowel diseases like ulcerative colitis, include sulfasalazine, balsalazide, and olsalazine. These medications are also aminosalicylates and work similarly to reduce inflammation in the colon.

Balsalazide is generally considered to have a low risk of affecting the kidneys. However, as with any medication, there is a potential for adverse effects, and kidney function should be monitored, especially in patients with pre-existing kidney conditions or those taking other medications that may impact renal function. It is important for patients to discuss any concerns with their healthcare provider.

Balsalazide and mesalamine are both medications used to treat inflammatory bowel diseases, such as ulcerative colitis. The primary difference between them lies in their formulation and delivery mechanism. Balsalazide is a prodrug that is converted into mesalamine in the colon, where it exerts its therapeutic effects. Mesalamine, on the other hand, is the active form of the drug and is available in various formulations designed to release the medication directly in the colon. The choice between the two may depend on the specific needs of the patient, the severity of the condition, and the physician's preference.

Balsalazide is classified as an anti-inflammatory drug, specifically a 5-aminosalicylic acid (5-ASA) derivative. It is used primarily in the treatment of ulcerative colitis.

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