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When considering treatment with Ritlecitinib, it is important to be aware of the associated risks and necessary precautions. This medication can lower your immune system's ability to fight infections, leading to a heightened risk of serious infections. Additionally, there are potential risks related to cancer, cardiovascular issues, and allergic reactions. Below are key safety details:

• Infection Risks: Ritlecitinib can compromise your immune system, increasing the likelihood of bacterial, viral, or fungal infections. This risk is higher if you are also taking other immune-suppressing drugs. Notify your doctor immediately if you experience symptoms like persistent cough, fever, chills, or a sore throat. Routine monitoring for infections is recommended, and testing for tuberculosis (TB) is necessary before and during treatment, especially if you have been in regions where TB and other fungal infections are prevalent.

• Cancer Risks: There is a potential risk of developing cancers such as lymphoma and skin cancer while on Ritlecitinib. This risk may be elevated for smokers or those with a history of cancer. Regular skin examinations and monitoring for any unusual changes in your skin or unexplained weight loss are advised.

• Cardiovascular and Blood Clot Risks: The medication may increase the risk of blood clots, heart attack, or stroke, particularly in individuals over 50 with existing heart disease risk factors, or those who smoke. Immediate medical attention is required if you experience symptoms such as chest pain, shortness of breath, sudden dizziness, or swelling in the legs.

• Allergic Reactions: Although rare, serious allergic reactions, including anaphylaxis, may occur. Seek emergency medical care if you notice swelling of the lips, tongue, or throat, or have difficulty breathing.

• Lab Test Changes: Ritlecitinib may cause changes in blood tests, such as reduced white blood cell or platelet counts and increased liver enzymes. Regular lab tests will be conducted to monitor these effects.

• Vaccinations: Ensure all vaccinations are up-to-date before starting Ritlecitinib, and avoid live vaccines during treatment, as the effects of the medication on vaccine efficacy are unknown.

Discuss these risks and management strategies with your healthcare provider to ensure safe and informed use of Ritlecitinib.

When taking this medication, it's important to be aware of potential side effects. Some common, typically mild side effects include headache, diarrhea, acne, rash, and hives. These symptoms usually don't cause significant issues, but if they persist or worsen, consulting a healthcare provider is advisable.

Other side effects might occur and may require attention if they become troublesome. These include fever, dizziness, small red bumps on the skin known as folliculitis, dry and itchy skin referred to as eczema, herpes zoster infections, and mouth ulcers or pain.

Rare but serious side effects demand immediate medical attention. These include signs of a stroke such as sudden weakness, speech difficulties, and confusion; arterial thrombosis characterized by chest pain and shortness of breath; pulmonary embolism with symptoms like cough and chest pain; and deep vein thrombosis, indicated by leg cramps and swelling. Additionally, serious bleeding issues, as well as severe infections, should be promptly addressed. An allergic reaction, which is also rare, can manifest as hives, rash, faintness, trouble breathing, and swelling of the lips or tongue. If any severe symptoms arise, seeking urgent medical care is crucial.