Methotrexate Sodium (pf) Coupons & Discount Card - Compare Prices Near You

Methotrexate is a medication that is sometimes associated with serious and potentially life-threatening side effects. It is primarily prescribed for treating cancer and severe conditions resulting from an overactive immune system, such as psoriasis and rheumatoid arthritis. Below are important safety considerations and warnings when using this drug:

• Preservative-Free Formulations: Methotrexate formulations containing preservatives should not be used for high-dose treatments or for intrathecal injections (around the spinal cord).

• Pregnancy Risks: Methotrexate can cause birth defects and even death in unborn babies. Women should avoid becoming pregnant while using this medication. It is contraindicated for pregnant women with psoriasis or rheumatoid arthritis.

• Kidney and Fluid Retention Issues: Patients with kidney problems or excess body fluids (ascites, pleural effusion) require close monitoring. Dosage adjustments or discontinuation may be necessary.

• Drug Interactions: High-dose methotrexate can rarely cause severe blood/bone marrow issues and gastrointestinal diseases when used with non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin and ketoprofen. NSAIDs should not be used with high-dose methotrexate. Low-dose methotrexate for rheumatoid arthritis may be used with NSAIDs/aspirin only under medical supervision. If prescribed low-dose aspirin for heart attack or stroke prevention, continue unless advised otherwise by your doctor.

• Liver Concerns: Long-term use of methotrexate may rarely lead to liver problems. Regular liver biopsies might be recommended for ongoing treatment.

• Other Serious Side Effects: Rarely, methotrexate can cause lung issues, infections (Pneumocystis jiroveci pneumonia), severe skin reactions, diarrhea, and mouth sores. Report any new symptoms to your healthcare provider immediately.

• Tumor Growths: In very rare cases, abnormal growths or tumors might develop. If new lumps appear, contact your doctor immediately.

• Tumor Lysis Syndrome: When treating tumors, methotrexate may cause rapid cancer cell destruction, leading to tumor lysis syndrome. To minimize risk, maintain hydration, and follow any additional medication plans prescribed by your doctor. Report symptoms like irregular heartbeat, side pain, kidney issues, or muscle weakness promptly.

• Radiation Therapy: Methotrexate may increase the risk of tissue and bone damage when used alongside radiation treatment. Discuss the potential risks and benefits with your healthcare provider.

In case of overdose or emergency, seek immediate medical attention. Always consult your healthcare provider for personalized advice and before making any changes to your medication regimen.

You might experience mild side effects such as nausea, vomiting, stomach pain, drowsiness, or dizziness. These symptoms are generally manageable, but if they persist or worsen, it’s important to consult with your healthcare provider. Temporary hair loss is also a possibility, but rest assured that normal hair growth typically resumes once treatment concludes.

While many individuals do not experience serious side effects, it's crucial to be aware of them. Notify your healthcare provider immediately if you develop mouth sores, diarrhea, signs of anemia like unusual tiredness or pale skin, or symptoms indicating liver issues such as persistent nausea, dark urine, abdominal pain, or yellowing of the skin or eyes. Other serious side effects to watch for include easy bruising or bleeding, black stools, swollen glands, bone pain, unusual skin changes, signs of kidney problems like changes in urination, dry cough, or muscle weakness.

Seek urgent medical attention if you encounter very serious side effects such as an irregular heartbeat, vision changes, one-sided weakness, a severe headache, neck stiffness, mood alterations, or seizures. This medication may also reduce your ability to fight infections, increasing the risk of severe infections. Promptly report any signs of infection, such as a persistent sore throat, fever, chills, or cough.

Allergic reactions to this medication are rare but can be serious. If you notice symptoms like a rash, itching, swelling, severe dizziness, or difficulty breathing, seek medical help immediately. This summary does not cover all potential side effects, so if you notice any unusual changes, reach out to your healthcare provider for further advice.