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Trexall

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Methotrexate is prescribed for treating specific cancers, such as acute lymphoblastic leukemia and non-Hodgkin's lymphoma. It is also used for severe psoriasis when other treatments have failed, and for managing rheumatoid arthritis. Additionally, it can treat polyarticular juvenile idiopathic arthritis in children. As an antimetabolite, methotrexate works by slowing or halting the growth of cancer cells and preventing the immune system from attacking healthy tissues. Starting methotrexate early in rheumatoid arthritis can help minimize joint damage and maintain joint function.
Our Trexall coupons are free to use. You can print the coupon, email it to yourself, or receive the Trexall coupon via text message. To get your free discount, show the pharmacist your Trexall savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Trexall prices will update based on your prescription needs. Above our Trexall coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Trexall savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.
Trexall WarningsTrexall Side EffectsInteractionsFAQs

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10MG, Trexall (30 Tablets)

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$1386.66

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Trexall dosage forms

The average cost for 30 Tablets of Trexall at 5MG is $658.56 with a free coupon. This is 13.47% off the average retail price of $4887.53
DosageQuantityPrice fromPer unit
5MG30 Tablets$658.56$21.95
7.5MG30 Tablets$1039.65$34.66
10MG30 Tablets$1327.53$44.25
15MG30 Tablets$2091.3$69.71

Trexall Warnings

Methotrexate has rarely caused serious (sometimes fatal) side effects. This medication should be used only to treat cancer or severe diseases caused by an overactive immune system (such as psoriasis, rheumatoid arthritis). Methotrexate has caused birth defects and death in unborn babies. Women must avoid becoming pregnant while taking this medication. Pregnant women who have psoriasis or rheumatoid arthritis must not use methotrexate. (See also Precautions section.) If you have kidney problems or excess body water (ascites, pleural effusion), you must be closely monitored and your dose may be adjusted or stopped by your doctor. Methotrexate (usually at high dosages) has rarely caused severe (sometimes fatal) blood/bone marrow problems (decreasing your body's ability to fight infections) and stomach/intestinal disease (such as bleeding) when used at the same time as non-steroidal anti-inflammatory drugs (NSAIDs such as indomethacin, ketoprofen). NSAIDs should not be used with high-dose methotrexate. Caution is advised if you also take aspirin. NSAIDs/aspirin may be used with low-dose methotrexate such as for the treatment of rheumatoid arthritis if directed by your doctor. If your doctor has told you to take low-dose aspirin to prevent heart attack or stroke (usually 81-162 milligrams a day), you should keep taking the aspirin unless your doctor tells you not to. Ask your doctor or pharmacist for more details on the safe use of these drugs (such as close monitoring by your doctor, keeping the same doses of NSAIDs). In rare instances, this drug may also cause liver problems when it is used for long periods of time. If you are using methotrexate long term, a liver biopsy is usually recommended. Methotrexate use has rarely caused serious (sometimes fatal) side effects, such as lung problems, lung infections (Pneumocystis jiroveci pneumonia), skin reactions, diarrhea, and mouth sores (ulcerative stomatitis). () Lumps (tumors/abnormal growths) may very rarely appear during methotrexate use. The drug must be stopped and treatment may be needed. Tell your doctor right away if new lumps/growths occur. When used to treat tumors, methotrexate sometimes causes side effects due to the rapid destruction of cancer cells (tumor lysis syndrome). To lower your risk, drink plenty of fluids unless your doctor directs you otherwise. Also, your doctor may prescribe an additional medication. Tell your doctor right away if you have symptoms such as irregular heartbeat, low back/side pain, signs of kidney problems (such as pink/bloody urine, change in the amount of urine, painful urination), or muscle spasms/weakness. When this medication is used with radiation treatment, it may rarely increase the risk of tissue and bone damage. Discuss the risks and benefits of your treatment with your doctor.

Trexall Side Effects

You might experience mild side effects such as nausea, vomiting, stomach pain, drowsiness, or dizziness. These are generally temporary, but if they persist or worsen, consult a healthcare professional. Temporary hair loss could also occur, but hair growth typically resumes after treatment ends.

While many people do not experience serious side effects, it's important to be aware of them. Contact a healthcare provider if you notice mouth sores, diarrhea, signs of anemia like unusual tiredness or pale skin, symptoms of liver issues such as persistent nausea, dark urine, abdominal pain, or yellowing of the skin or eyes. Other serious side effects include easy bruising or bleeding, black stools, swollen glands, bone pain, unusual skin pain or discoloration, signs of kidney problems like changes in urine output, a persistent dry cough, or muscle weakness.

Seek immediate medical assistance for very serious side effects such as weakness on one side of the body, neck stiffness, severe headache, vision changes, irregular heartbeat, mood changes, or seizures. This medication may also reduce your body's ability to fight infections, increasing the risk of serious infections. Contact a healthcare provider if you develop persistent sore throat, fever, chills, or cough.

Although rare, severe allergic reactions can occur. Seek emergency help if you experience symptoms like rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. This summary does not cover all possible side effects. If you notice other unusual effects, reach out to a healthcare provider for advice.

Interactions

Some medications that may interact with this drug include: Acitretin, asparaginase, Leflunomide, drugs that could harm the kidneys (like Cisplatin), and drugs that could affect the liver (such as Azathioprine, Sulfasalazine, and retinoids like Isotretinoin). Other interacting drugs are penicillins, Phenytoin, Probenecid, procarbazine, Pyrimethamine, sulfa medications, and tetracyclines. Additionally, certain medications that lower stomach acid, such as proton pump inhibitors (PPIs) like esomeprazole, Omeprazole, and Pantoprazole, may increase methotrexate levels in your blood. This can heighten the risk of side effects, particularly with high doses of methotrexate. Consult your doctor or pharmacist for more information and advice on minimizing these risks.
Trexall FAQs
What is the most common side effect of methotrexate?

The most common side effect of methotrexate is gastrointestinal upset, which can include nausea and vomiting.

Trexall is used to treat certain types of cancer, severe psoriasis, and rheumatoid arthritis. It works by slowing or stopping the growth of cancer cells and suppressing the immune system to reduce inflammation.

The cost of Trexall can vary depending on factors such as the pharmacy, location, dosage, and whether the patient has insurance coverage. It is recommended to check with local pharmacies or use online tools to compare prices. Additionally, patients should consult with their insurance provider to determine if Trexall is covered under their plan and what the copay might be.

The generic name for Trexall is methotrexate.

When taking methotrexate, it is advisable to avoid foods that are high in folic acid, as methotrexate can interfere with folic acid metabolism. Foods rich in folic acid include leafy green vegetables, fortified cereals, and certain beans. Additionally, alcohol consumption should be limited or avoided, as it can increase the risk of liver damage when combined with methotrexate. It is important to follow any specific dietary recommendations provided by a healthcare provider.

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