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Mercaptopurine

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generic Purixan

Mercaptopurine, also known as 6-MP, is a medication primarily used to treat acute lymphoblastic leukemia (ALL), a type of cancer. It is usually prescribed in combination with other cancer treatments. Mercaptopurine is available in tablet form as a generic medication or as an oral suspension under the brand name Purixan. This drug works as an antimetabolite, specifically a nucleoside metabolic inhibitor, which interferes with the ability of cancer cells to produce genetic material. This interruption prevents cancer cells from growing and leads to their destruction. While mercaptopurine can be effective in managing ALL, it may also be used off-label for certain gastrointestinal conditions like Crohn's disease and ulcerative colitis. Patients taking this medication may experience side effects such as reduced appetite, stomach discomfort, and general malaise. It is important to discuss the potential risks and benefits of mercaptopurine with a healthcare professional, particularly when considering its use in children and young adults. Always consult your doctor, nurse, or pharmacist before starting any new medication or treatment plan.
Our coupons are free to use. Before paying, show the pharmacist your Mercaptopurine savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Mercaptopurine prices will update based on your prescription needs. Above our Mercaptopurine coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Mercaptopurine at the lowest price with our prescription discount card.

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50MG, Mercaptopurine (30 Tablets)

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CVS

$27.72

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Walmart

$28.22

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Walgreens

$29.90

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Rite Aid

$36.42

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$51.06

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Mercaptopurine savings card

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$27.72

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Mercaptopurine dosage forms

The average cost for 30 Tablets of Mercaptopurine (generic Purixan) at 50MG is $27.75 with a free coupon. This is 14.73% off the average retail price of $188.4
DosageQuantityPrice fromPer unit
50MG30 Tablets$27.75$0.93

Mercaptopurine Warnings

The following safety information outlines important considerations and warnings associated with the use of mercaptopurine. It is crucial to review these details and consult with your healthcare provider if you have any questions or concerns.

  • Blood Cell Count Reduction: Mercaptopurine may lead to decreased production of blood cells in the bone marrow, resulting in anemia due to low red blood cells, increased susceptibility to infections from low white blood cells, and an elevated risk of bleeding from low platelet counts. The risk of these effects is heightened when taken with allopurinol (Zyloprim), mesalamine, sulfasalazine (Azulfidine), or other medications that suppress bone marrow.

  • Liver Damage: This medication can potentially harm the liver, with severe cases being fatal. Symptoms like jaundice (yellowing of the skin or eyes) can emerge within the first two months of treatment but may occur at any time. Regular blood tests are recommended to monitor liver function. Report any signs of liver issues, such as yellowing of the skin or eyes, dark urine, pale stools, appetite loss, diarrhea, or stomach bloating, to your healthcare provider. You may need to discontinue use if liver damage is suspected. The risk is greater with higher doses, other liver-affecting drugs, or a history of liver disease.

  • Cancer Development: There is an increased risk of developing new cancers, including blood or skin cancers, during treatment with mercaptopurine. This risk correlates with the extent and duration of immune suppression from mercaptopurine and other similar medications. Discuss any concerns with your healthcare provider.

  • Pregnancy Risks: Mercaptopurine poses a risk to an unborn baby if taken during pregnancy, with reported cases of miscarriage and stillbirth in the first trimester. Both men and women capable of conceiving should use effective contraception during treatment. Continue using birth control for three months after stopping the medication for men, and for six months for women. Inform your healthcare provider immediately if pregnancy occurs during treatment.

Please ensure all safety precautions are discussed with your healthcare provider to minimize risks while using mercaptopurine.

Mercaptopurine Side Effects

Common side effects:

  • nausea
  • vomiting
  • diarrhea
  • loss of appetite
  • temporary hair loss
  • general feeling of discomfort
  • rash

Less common but important to monitor:

  • mouth sores
  • itchy skin or hives
  • darkening of skin color
  • signs of infection

Serious side effects:

  • signs of liver problems (persistent nausea, vomiting, stomach pain, yellowing of the skin or eyes, dark urine)
  • low blood cell counts (unusual tiredness, pale skin, frequent infections, easy bruising or bleeding)
  • increased risk of certain types of cancer
  • swollen lymph nodes
  • night sweats
  • unexplained weight changes
  • severe allergic reaction (rash, swelling, dizziness, trouble breathing)

Mercaptopurine Interactions

Interactions with high risk of serious adverse effects and should be avoided:

  • Febuxostat
  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Varicella Virus Vaccine, Live
  • Zoster Vaccine, Live
  • Azathioprine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

Mercaptopurine FAQs
What is the mercaptopurine used for?

Mercaptopurine is used primarily in the treatment of certain types of cancer, such as acute lymphoblastic leukemia (ALL). It is also used in the management of some autoimmune diseases, including Crohn's disease and ulcerative colitis, as part of immunosuppressive therapy.

Mercaptopurine is not commonly associated with weight gain as a side effect. However, individual responses to medication can vary. If there are concerns about weight changes while taking mercaptopurine, it is advisable to consult with a healthcare provider for personalized advice and management.

Yes, mercaptopurine is a chemotherapy medication. It is used primarily in the treatment of certain types of cancer, such as acute lymphoblastic leukemia (ALL).

Mercaptopurine is not a steroid. It is an immunosuppressive medication used primarily in the treatment of certain types of cancer, such as acute lymphoblastic leukemia, and in some autoimmune conditions. It works by interfering with the growth of cancer cells and suppressing the immune system.

Yes, mercaptopurine can cause hair loss as a side effect, although it is not very common. If hair loss occurs, it is usually temporary and hair growth may resume after the treatment is completed. If there are concerns about this side effect, it is advisable to discuss them with a healthcare provider.