Myfembree

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This medication combines three active ingredients: relugolix, estradiol, and norethindrone. It is prescribed for women who have not yet reached menopause to help control heavy menstrual bleeding related to uterine fibroids or for managing pain from endometriosis. Relugolix functions by reducing the production of specific hormones (luteinizing hormone and follicle-stimulating hormone), which subsequently lowers the levels of female sex hormones like estrogens. Estradiol helps to minimize bone density loss caused by relugolix, and norethindrone is included to reduce the risk of uterine cancer associated with estradiol use.
Our Myfembree coupons are free to use. You can print the coupon, email it to yourself, or receive the Myfembree coupon via text message. To get your free discount, show the pharmacist your Myfembree savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Myfembree prices will update based on your prescription needs. Above our Myfembree coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Myfembree savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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40-1-0.5MG, Myfembree (30 Tablets)

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CVS

$1345.01

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$1324.92

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Walmart

$1371.17

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Walgreens

$1382.16

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Myfembree savings card

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$1345.01

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Myfembree dosage forms

The average cost for 30 Tablets of Myfembree at 40-1-0.5MG is $1283.74 with a free coupon. This is 26.95% off the average retail price of $4763.94
DosageQuantityPrice fromPer unit
40-1-0.5MG30 Tablets$1283.74$42.79

Warnings

This medication involves a combination of hormones that can elevate the risk of developing blood clots, which may occur in the legs, lungs, or heart. It is crucial to avoid using this medication if you are over 35 years old and smoke cigarettes or use tobacco products. Smoking significantly increases the likelihood of experiencing a stroke, heart attack, blood clots, and elevated blood pressure while taking this treatment. The danger of these severe conditions grows with age and the number of cigarettes smoked. Therefore, it is advised not to smoke or use tobacco while on this medication.

Key Points:

  • Hormone treatment can raise the risk of blood clots.
  • Do not use if you are over 35 and smoke.
  • Smoking heightens the risk of stroke, heart attack, and high blood pressure.
  • The risk increases with age and smoking frequency.
  • Avoid smoking or using tobacco during treatment.

Myfembree Side Effects

Some people taking this medication may experience hot flashes, increased sweating, night sweats, or changes in menstrual periods. These are common and usually mild, but if they persist or worsen, consult your healthcare provider. Hair thinning or loss might occur, and it's uncertain if hair will regrow after treatment. It's important to monitor blood pressure, as this medication can cause an increase; report high readings to your healthcare provider.

Serious side effects, though less common, require immediate medical attention. These include breast lumps, significant mood changes (like depression or anxiety), signs of liver damage (persistent nausea, loss of appetite, jaundice, dark urine), unusual vaginal bleeding, and symptoms of high blood sugar (increased thirst and urination). Additionally, this medication lowers estrogen levels, potentially leading to bone loss (osteoporosis), which may be permanent. Discuss with your healthcare provider about calcium and vitamin D supplements for bone health.

Rarely, the medication can cause severe complications due to blood clots, such as heart attack, stroke, or clots in the lungs or legs. Seek urgent medical help if you experience shortness of breath, chest pain, sudden dizziness, pain/swelling in the limbs, or sudden vision changes. Though rare, an allergic reaction is possible, manifesting as a rash, swelling, severe dizziness, or breathing difficulties. Immediate medical attention is crucial in such cases. Always inform your healthcare provider about any other unexpected effects you experience.

Interactions

Certain medications can interact with this drug. These include aromatase inhibitors like Anastrozole, Exemestane, and Letrozole; fezolinetant; ospemifene; Tamoxifen; Tranexamic Acid; and some combination drugs for chronic hepatitis C, such as ombitasvir/paritaprevir/ritonavir, with or without dasabuvir. Additionally, other drugs might influence how your body processes this medication, potentially altering its effectiveness. Examples are Erythromycin, Rifampin, St. John's wort, and some seizure medications like Carbamazepine and Phenytoin. Moreover, this medication could affect certain lab tests, like those for clotting factors and thyroid function, which might lead to inaccurate results. Inform lab personnel and your healthcare providers that you are taking this medication.
Myfembree FAQs
What does Myfembree do to the body?

Myfembree is a medication that combines relugolix, estradiol, and norethindrone acetate. It is used to manage heavy menstrual bleeding associated with uterine fibroids in premenopausal women. Relugolix works by reducing the production of certain hormones, leading to decreased estrogen levels, which helps shrink fibroids and reduce bleeding. Estradiol and norethindrone acetate are added to help mitigate the side effects of low estrogen, such as bone loss.

Myfembree is not specifically indicated for weight loss. While some individuals may experience changes in weight as a side effect, it is not a common or intended effect of the medication. If there are concerns about weight changes while taking Myfembree, it is advisable to consult with a healthcare provider.

The best medicine to shrink fibroids can vary depending on the individual's specific situation, but commonly used medications include Gonadotropin-releasing hormone (GnRH) agonists, which can help reduce the size of fibroids by lowering estrogen and progesterone levels. Another option may be selective progesterone receptor modulators (SPRMs), such as ulipristal acetate, which can also help in reducing fibroid size. It is important for the individual to consult with a healthcare provider to determine the most appropriate treatment based on their medical history and condition.

Myfembree has been shown to be effective in clinical trials for the management of heavy menstrual bleeding associated with uterine fibroids in premenopausal women. Patients have reported a significant reduction in menstrual blood loss. However, individual responses to the medication can vary, and it is important for patients to discuss with their healthcare provider to determine if it is the right treatment option for their specific condition.

Yes, Myfembree is a medication that can help reduce the size of uterine fibroids. It works by altering hormone levels, which can lead to a decrease in fibroid size and associated symptoms. However, individual responses to the medication can vary, and it is important for patients to discuss treatment options with their healthcare provider.

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