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Tamoxifen, while effective, may infrequently lead to severe and potentially life-threatening conditions such as strokes, blood clots in the lungs or legs, and uterine cancer. It is important for patients using tamoxifen to lower their risk of breast cancer or with ductal carcinoma in situ (DCIS) to thoroughly discuss the potential advantages and disadvantages of this medication with their healthcare provider. For those using tamoxifen to treat breast cancer, the therapeutic benefits generally exceed the risk of side effects associated with the drug.

• Immediately seek medical attention if you experience any signs of stroke or blood clots in the lungs or legs. These symptoms include:

  • Weakness on one side of the body
  • Difficulty speaking
  • Sudden changes in vision
  • Confusion
  • Shortness of breath
  • Chest pain
  • Calf pain or swelling

• Contact your doctor promptly if you notice any symptoms indicative of uterine cancer, such as:

  • Unusual menstrual changes (in terms of bleeding amount or timing)
  • Abnormal vaginal discharge
  • Pain or pressure in the lower abdomen (below the navel)

These guidelines are crucial for ensuring safe and informed use of tamoxifen.

You may experience some mild side effects from this medication, such as hot flashes, nausea, leg cramps, muscle aches, hair thinning, headaches, and numb or tingling skin. Men may also notice a decrease in sexual ability or interest. While these effects are generally not cause for concern, if they persist or worsen, it is important to consult your healthcare provider.

There are more serious side effects that require immediate attention. These include changes in vision like blurred vision, eye pain, easy bruising or bleeding, mood or mental changes, swelling in the ankles or feet, unusual tiredness, persistent sore throat or fever indicating infection, and symptoms of liver disease such as ongoing nausea, vomiting, loss of appetite, abdominal pain, yellowing of the skin or eyes, and dark urine.

Although a severe allergic reaction to this medication is rare, it is crucial to seek medical help immediately if you experience symptoms such as a rash, itching or swelling particularly of the face, tongue, or throat, severe dizziness, or trouble breathing. If you notice any other effects not mentioned here, reach out to your healthcare provider for guidance.