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This information outlines important safety considerations for the use of this medication. Please read carefully and consult your healthcare provider if you have any questions or concerns.

• Medication Interactions: Prior to starting norethindrone, inform your healthcare provider or pharmacist about all medications and supplements you are currently taking. This will help them to identify any potential interactions.

• Ectopic Pregnancy or Ovarian Cyst: If you become pregnant while taking norethindrone, there is a small risk that the pregnancy might be ectopic, occurring outside the uterus. This condition can be serious. Seek immediate medical attention if you experience symptoms such as cramping or pain in the lower abdomen or shoulder.

• Irregular Vaginal Bleeding: While irregular vaginal bleeding is a common side effect of progestin-only pills (POPs) like norethindrone, it can occasionally indicate a more serious issue such as an infection or cancer. If you have concerns about irregular bleeding or if you experience an absence of bleeding, consult your healthcare provider to rule out pregnancy.

• Possible Risk of Cancer: Some research suggests that combination birth control pills may increase the risk of breast or ovarian cancer. It is unclear if norethindrone or other POPs carry the same risk. Discuss any concerns about cancer risks with your healthcare provider.

Contraindications:

This medication should not be used under certain conditions, as it may pose significant health risks. If any of the following apply to you, consult your healthcare provider before use:

• Pregnancy
• Diagnosed or suspected breast cancer
• Undiagnosed bleeding between menstrual cycles
• Liver tumors, whether benign or cancerous
• Acute liver disease

When taking Norlyda, a progestin-only oral contraceptive, it's important to be aware of potential interactions with other medications and substances that could affect its effectiveness or lead to side effects.

Medications That May Reduce Norlyda's Effectiveness:

• Antibiotics and Antifungals: Certain antibiotics and antifungal medications can decrease the effectiveness of hormonal contraceptives, potentially leading to unintended pregnancy or breakthrough bleeding. Examples include Rifampin, griseofulvin, and Ketoconazole.

• Anticonvulsants: Medications used to treat seizures, such as Phenytoin, Carbamazepine, and Phenobarbital, may reduce the effectiveness of Norlyda.

• HIV Protease Inhibitors: Some medications used to treat HIV, like nelfinavir and Nevirapine, can affect hormone levels and may decrease contraceptive efficacy.

• Herbal Products: St. John's Wort, a common herbal supplement, may reduce the effectiveness of hormonal contraceptives.

Medications That May Be Affected by Norlyda:

• Diabetes Medications: Norlyda may interfere with blood glucose control, potentially reducing the effectiveness of medications like semaglutide. It's important to monitor blood sugar levels closely and consult with a healthcare provider for possible dose adjustments.

Food Interactions:

• Grapefruit Juice: Consuming grapefruit or grapefruit juice can increase the blood levels of norethindrone, the active ingredient in Norlyda, which may lead to increased side effects. It's advisable to limit grapefruit intake while using this medication.

General Recommendations:

• Consult Your Healthcare Provider: Always inform your doctor about all medications, supplements, and herbal products you are currently using. This will help them assess potential interactions and provide guidance on managing them.

• Monitor for Side Effects: Be vigilant for any unusual symptoms or side effects when starting a new medication alongside Norlyda. If you experience issues like nausea, vomiting, unusual bleeding, or changes in blood sugar levels, contact your healthcare provider promptly.

• Use Additional Contraceptive Methods if Necessary: If you're taking medications known to reduce the effectiveness of hormonal contraceptives, consider using an additional form of birth control, such as condoms, to ensure protection against unintended pregnancy.

By staying informed and communicating openly with your healthcare provider, you can effectively manage potential interactions and maintain the efficacy of Norlyda as your contraceptive method.