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This medication carries several important safety considerations and warnings. Please review the information below carefully and reach out to your healthcare provider if you have any questions or concerns.

• Incompatibility with Other Weight Loss Drugs: Phendimetrazine should not be combined with other weight loss medications, including over-the-counter options. Discuss any questions about your treatment plan with your healthcare team.

• Tolerance Development: Over time, phendimetrazine may become less effective, a phenomenon known as tolerance. Increasing the dosage is not safe and could lead to serious side effects. If you notice your appetite returning or weight gain, consult your prescriber for alternative treatments.

• Misuse and Dependence Potential: Like other stimulants, phendimetrazine can be misused and may lead to dependence, resulting in a condition known as stimulant use disorder. To minimize this risk, it is typically prescribed for short-term use only. Follow your healthcare provider’s instructions precisely and discuss long-term weight management options if needed.

• Pulmonary Hypertension Risk: Although rare, phendimetrazine can cause high blood pressure in the lungs, known as pulmonary hypertension, which is potentially life-threatening. This risk increases with use beyond three months. If you experience symptoms such as difficulty breathing, chest pain, fainting, or leg swelling, discontinue use and seek medical attention immediately.

• Heart Valve Issues: Use of phendimetrazine and similar stimulants has been associated with heart valve problems, especially with long-term use or when combined with other appetite suppressants. Report symptoms like dizziness, chest pain, swelling in the legs or ankles, irregular heartbeat, fatigue, or breathing difficulties to your healthcare provider.

• High Blood Pressure Risk: Alert your healthcare provider if you have high blood pressure. Phendimetrazine can exacerbate this condition, necessitating more frequent blood pressure monitoring during treatment.

• Low Blood Sugar in Diabetic Patients: Individuals with diabetes using medications like insulin or sulfonylureas are at increased risk for low blood sugar when taking phendimetrazine, due to potential changes in eating habits. Your diabetes management plan may need adjustment upon starting this medication.

Contraindications: This medication should not be used if you have the following conditions, as it may pose significant health risks. Consult your healthcare provider if any of these apply to you:

• Heart issues (such as coronary artery disease, stroke, irregular heartbeat, uncontrolled high blood pressure, congestive heart failure)
• Use of or recent use of monoamine oxidase inhibitors (MAOIs) in the past 14 days
• Concurrent use of other weight-loss medications
• Overactive thyroid (hyperthyroidism)
• Glaucoma
• Agitation or distress
• History of substance use disorder
• Pregnancy or breastfeeding

Always consult your healthcare provider to ensure this medication is appropriate for your health condition and circumstances.

Common side effects:

• Dizziness
• Dry mouth
• Difficulty sleeping
• Irritability
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Restlessness
• Nervousness
• Shakiness
• Sweating
• Changes in sex drive

Less common but important to monitor:

• Increase in blood pressure
• Fast or irregular heartbeat
• Mental or mood changes including agitation or hallucinations
• Uncontrolled muscle movements

Serious side effects:

• Heart valve problems
• Pulmonary hypertension
• Chest pain
• Difficulty breathing
• Fainting
• Swelling of the legs
• Severe headaches
• Vision changes
• Seizures
• Weakness on one side of the body
• Serious allergic reaction (rash, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, moclobemide, phenelzine, procarbazine, Rasagiline, Selegiline, Tranylcypromine)
• Stimulants (amphetamines, Methylphenidate, cocaine, MDMA)
• Brofaromine, Clorgyline, Furazolidone, Iproniazid, Lazabemide, Nialamide, Pargyline, Sibutramine, Toloxatone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Appetite-suppressant drugs (phentermine, ephedra)
• Iobenguane I 131

Interactions with low risk that usually do not require a change in therapy:

• Products causing drowsiness (opioids like codeine, alcohol, marijuana, anxiety medications like Alprazolam, muscle relaxants, certain antihistamines)
• Caffeine