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This medication comes with important safety and warning information that you should be aware of before using it. Below are the critical details you need to consider. Consult your healthcare provider with any concerns or questions.

• Risk of Misuse and Dependence: Amphetamines carry a significant risk of misuse and can be habit-forming. Misuse may lead to addiction and severe side effects, such as increased heart rate, high blood pressure, depression, nightmares, aggressive behavior, and even thoughts of self-harm. Long-term use can lead to dependence, making withdrawal symptoms like irritability, nightmares, and sleep issues possible if stopped abruptly. Those with a history of substance or alcohol use disorder should exercise caution and follow the prescribed dosage.

• Heart and Blood Pressure Concerns: This medication can cause serious cardiovascular issues, including sudden death, stroke, and heart attacks, even at normal doses. It may also elevate blood pressure and heart rate. Inform your healthcare provider if you have a history of heart problems, as they need to evaluate your heart health before starting the medication. Seek immediate medical attention if you experience unexplained fainting, chest pain during physical activity, or irregular heartbeats.

• Mental Health Effects: Amphetamines may induce or worsen psychiatric conditions, leading to hallucinations, aggressive behavior, unclear thinking, and mania. These symptoms can occur even in individuals without prior mood disorders. Contact your healthcare provider if you experience these symptoms, as you may need to discontinue the medication.

• Growth Impact in Children: The use of amphetamines in children has been associated with weight loss and slowed growth. Your child's healthcare provider will monitor their growth closely. If significant weight loss or growth retardation is observed, treatment may be adjusted or stopped.

• Seizure Risk: Amphetamines can increase the risk of seizures, especially in those with a history of seizures. If you experience a seizure, seek medical help immediately as discontinuation of the medication may be necessary.

• Raynaud's Phenomenon: This condition affects blood flow to fingers and toes, causing them to change color and feel cold, numb, or painful. Inform your provider if you notice these symptoms, which typically improve with dose adjustments or discontinuation of the medication.

• Serotonin Syndrome: There is a risk of serotonin syndrome, a potentially life-threatening condition, particularly when amphetamines are used with other medications that increase serotonin levels, such as certain antidepressants and migraine medications. Symptoms include rapid heart rate, sweating, muscle stiffness, high fever, behavioral changes, and confusion. Seek immediate medical attention if you experience these symptoms.

• Vision Problems: Amphetamines may cause blurred vision or other visual disturbances. Report any visual changes to your healthcare provider.

Contraindications: Do not use this medication if you have certain heart problems, moderate-to-severe high blood pressure, an overactive thyroid, feelings of agitation, a history of drug misuse, or if you are currently taking or have recently taken a monoamine oxidase inhibitor (MAOI) within the last 14 days.

Always follow your healthcare provider's guidance and report any adverse effects or concerns promptly.

Common side effects:

• nausea
• stomach upset
• diarrhea
• dry mouth
• headache
• nervousness
• dizziness
• trouble sleeping
• loss of appetite
• weight loss
• irritability

• restlessness

  Less common but important to monitor:

• increased blood pressure
• symptoms of blood flow issues in the fingers or toes
• unusual wounds
• significant mood or behavior changes
• uncontrolled muscle movements
• changes in vision
• frequent or prolonged erections in males

• significant changes in sexual interest or ability

  Serious side effects:

• fainting
• severe headaches
• irregular heartbeat
• seizures
• symptoms of heart attack or stroke
• serotonin syndrome
• allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, Selegiline, and others)
• Dextroamphetamine
• Lisdexamfetamine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• MDMA
• St. John's wort
• SSRIs (Fluoxetine, paroxetine)
• SNRIs (Duloxetine, Venlafaxine)

Interactions with low risk that usually do not require a change in therapy:

• NSAIDs (Ibuprofen, Naproxen)