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The following safety information is crucial for understanding the potential risks and necessary precautions when using this medication. Please read carefully and discuss with your healthcare provider if you have any questions or concerns.

• Hormonal Effects and Withdrawal:

  • Long-term use of hydrocortisone (Anusol-HC) rectally may lead to a condition known as adrenal suppression, where the body reduces its production of steroid hormones due to the presence of the medication.
  • Abrupt discontinuation of this medication can result in withdrawal symptoms such as dizziness, fatigue, and nausea.
  • To prevent adrenal suppression, your healthcare provider might recommend a rectal exam to determine the suitability of this medication for you.
  • Do not stop using hydrocortisone (Anusol-HC) suddenly without consulting your healthcare provider.

• Increased Risk of Skin Infections:

  • Prolonged use of hydrocortisone (Anusol-HC) can increase the likelihood of developing fungal or bacterial infections.
  • Avoid using this medication if you have a current skin infection, as it may exacerbate the condition.
  • Contact your healthcare provider if you experience symptoms such as redness, swelling, pain, pus, or if your symptoms do not improve after seven days of treatment, as these could indicate a new infection.

• Skin Irritation and Damage:

  • Using hydrocortisone (Anusol-HC) for longer than recommended can result in skin irritation, characterized by thinning of the skin, stretch marks, spider veins, burning, itching, dryness, inflamed hair follicles, changes in skin color, or rash.
  • To avoid severe skin reactions, a rectal exam may be advised by your healthcare provider to ensure this medication is appropriate for your condition.
  • Report any new or worsening skin issues to your healthcare provider promptly.

Please consult your healthcare provider for further guidance and do not hesitate to discuss any concerns regarding the use of this medication.

When using this medication, some individuals may experience common, mild side effects such as redness, burning, itching, or skin irritation at the application site, along with dry skin. These effects typically resolve on their own, but if they persist or worsen, it's advisable to consult your healthcare provider for guidance.

Some users might also notice other side effects including inflamed hair follicles, acne-like bumps, changes in skin color, rash, heat rash, thinning skin, stretch marks, pruning or wrinkling of the skin, and increased hair growth. While these side effects are not as common, monitoring their severity and duration is important. If they become severe, seeking medical advice is recommended.

Serious side effects are rare but necessitate immediate medical attention. These include symptoms of a serious allergic reaction such as rash, itching or swelling, especially of the face, tongue, or throat, severe dizziness, and trouble breathing. Additionally, signs of serious infection like a sore throat that doesn't go away or fever, rectal bleeding, significant changes in skin appearance, or signs of excessive corticosteroid absorption like unusual tiredness, weight loss, headache, swelling of ankles or feet, increased thirst or urination, and vision problems should prompt urgent medical care.

Long-term use of this medication can, in rare cases, lead to withdrawal symptoms such as persistent fatigue, muscle weakness, poor appetite, weight loss, and abdominal pain. Always be vigilant about any changes and consult with your healthcare provider to ensure safe and effective use of the medication.