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Here are important safety considerations for the use of Taclonex (calcipotriene / betamethasone). It's crucial to understand these points and discuss any concerns with your healthcare provider to ensure safe use of this medication:

• High Calcium Levels: Taclonex may increase calcium levels in your blood or urine. Regular monitoring through lab tests may be required by your healthcare team. If high calcium levels are detected, discontinuation of the medication might be necessary until levels normalize. Consult your healthcare provider if you have any concerns.

• Changes in Stress Hormone Levels: Taclonex contains betamethasone, a corticosteroid that can elevate stress hormone levels, potentially causing symptoms such as weight gain and increased blood sugar. Children are particularly susceptible due to higher absorption rates. Increased risk is associated with long-term use, large treatment areas, use of other corticosteroid products, liver failure, broken skin, and occlusive dressings.

• Allergic Skin Reaction: There is a possibility of an allergic skin reaction to Taclonex. If you experience a rash or if your symptoms do not improve, consult your healthcare provider.

• Cataracts and Glaucoma: Use of Taclonex may elevate the risk of developing glaucoma or cataracts. Avoid application near the eyes and report any visual changes like blurred vision or eye pain to your healthcare provider immediately.

• Sun Sensitivity: This medication may increase skin sensitivity to sunlight. To prevent skin damage, avoid excessive sun exposure and tanning beds, and use sunscreen and protective clothing when outdoors.

These precautions are essential for the safe use of Taclonex, and regular communication with your healthcare provider is recommended to address any issues that may arise.

Common side effects:

• Itching
• Headache
• Runny nose
• Sore throat

Less common but important to monitor:

• Skin redness
• Burning
• Irritation

Serious side effects:

• Thinning or discoloration of the skin
• Appearance of small red bumps (folliculitis)
• Worsening of psoriasis
• Scaly rash
• Increased calcium levels in the blood
• Mental changes
• Unexplained constipation
• Unusual tiredness
• Weight loss
• Swelling of the ankles or feet
• Increased thirst or urination
• Vision problems
• Allergic reaction symptoms (rash, severe itching or swelling, dizziness, difficulty breathing)

When using a combination of Calcipotriene and betamethasone to treat psoriasis, it's important to be aware of potential interactions with other medications and supplements. Calcipotriene, a form of vitamin D, can be absorbed through the skin and may elevate calcium levels in the blood. Therefore, using this treatment alongside vitamin D supplements (such as cholecalciferol) or calcium supplements could increase the risk of hypercalcemia, a condition characterized by excessive calcium in the bloodstream. Symptoms of hypercalcemia include dizziness, weakness, lethargy, muscle pain, headache, loss of appetite, nausea, vomiting, and seizures. If you experience any of these symptoms, contact your healthcare provider promptly.

Additionally, betamethasone is a corticosteroid that, when absorbed systemically, can interact with various medications. For instance, combining betamethasone with certain antibiotics like Ciprofloxacin may increase the risk of tendon rupture. Furthermore, using betamethasone with other immunosuppressive agents can heighten the risk of infections. It's also important to note that corticosteroids can affect blood sugar levels, so individuals with diabetes should monitor their glucose levels closely while using this medication.

To minimize potential interactions, inform your healthcare provider about all medications, vitamins, and supplements you are currently taking before starting treatment with calcipotriene and betamethasone. This will help ensure the safe and effective use of the medication in managing your psoriasis.