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Constipation or an upset stomach are common side effects that some individuals may experience with this medication. These are usually mild, but if they persist or worsen, it is important to consult with a healthcare professional. While serious side effects are less common, it is crucial to remain vigilant for any signs. These can include nausea, vomiting, a loss of appetite, unexplained weight loss, mood or mental changes, and indications of kidney problems, such as changes in urination.

Additionally, some individuals may experience bone or muscle pain, headaches, increased thirst, increased urination, feelings of weakness or tiredness, or a rapid/pounding heartbeat. These symptoms should be discussed with a healthcare provider if they occur. Although rare, a serious allergic reaction is possible and requires immediate medical attention. Symptoms of such a reaction include a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, and difficulty breathing.

This summary does not encompass all potential side effects. If you encounter any other unusual symptoms, it is advisable to seek advice from a healthcare provider.

Some medications that can interact with this drug include digoxin and phosphate binders. Calcium can interfere with the absorption of other medications such as tetracycline antibiotics (like doxycycline and minocycline), bisphosphonates (such as alendronate), estramustine, levothyroxine, and quinolone antibiotics (including ciprofloxacin and levofloxacin). Additionally, certain drugs can reduce the absorption of vitamin D, including bile acid sequestrants (such as cholestyramine and colestipol), mineral oil, and orlistat. It is important to space out your doses of these medications from your calcium/vitamin D intake. Consult your doctor or pharmacist to determine the appropriate time interval between doses and to help you create a dosing schedule that accommodates all your medications.

Be sure to check the labels of all your prescription and over-the-counter products, including herbal supplements (like antacids, laxatives, and vitamins), as they may contain calcium, phosphate, or vitamin D. Consult your pharmacist for guidance on how to use these products safely.

Since vitamin D is very similar to calcitriol, avoid using medications containing calcitriol while taking vitamin D. This product may also interfere with certain laboratory tests, such as cholesterol tests, potentially leading to inaccurate results. Inform your healthcare providers and laboratory staff that you are using this product.