Apomorphine

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apomorphine

Apomorphine, marketed as Apokyn, is an injectable medication specifically used to manage "off" episodes in individuals with advanced Parkinson's disease. These episodes are characterized by reduced movement abilities between doses of regular Parkinson's medications. Apomorphine works as a dopamine agonist, meaning it activates dopamine receptors in the brain, helping to improve movement and reduce symptoms like tremors, stiffness, and slowed motion. It is important to note that Apomorphine is not a substitute for your regular Parkinson's medications but is used in conjunction with them. While it can significantly enhance movement during off periods, it may also cause side effects such as nausea and vomiting. Always consult with your healthcare provider to ensure this treatment is safe and appropriate for your condition. Continue taking all prescribed medications as directed by your doctor.
Our Apokyn coupons are free to use. You can print the coupon, email it to yourself, or receive the Apokyn coupon via text message. To get your free discount, show the pharmacist your Apokyn savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Apokyn prices will update based on your prescription needs. Above our Apokyn coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Apokyn savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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3ML of 30MG/3ML, Apomorphine (1 Cartridge)

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Walgreens

$315.68

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$361.38

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$986.28

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$998.52

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Apokyn savings card

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Walgreens

$315.68

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015995

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Apokyn dosage forms

The average cost for 1 Cartridge of Apokyn (apomorphine) at 3ML of 30MG/3ML is $363.96 with a free coupon. This is 22.22% off the average retail price of $1638.09
DosageQuantityPrice fromPer unit
3ML of 30MG/3ML1 Cartridge$363.96$363.96

Apokyn Warnings

The safety information provided outlines crucial warnings and precautions associated with the use of apomorphine (Apokyn). It is essential to thoroughly understand these details and discuss any concerns with your healthcare provider.

  • Severe Nausea and Vomiting: Nausea and vomiting are common side effects of apomorphine (Apokyn). Your healthcare provider may prescribe trimethobenzamide (Tigan) to manage these symptoms, as it was used in clinical trials. Avoid using other anti-nausea medications unless directed by your provider to prevent potential interactions.

  • Sleepiness and Sudden Sleep Episodes: Apomorphine (Apokyn) can cause sudden sleep episodes without prior drowsiness. Until you know how the medication affects you, refrain from driving or engaging in activities that require full attention. Inform your provider if you experience excessive daytime sleepiness or fall asleep unexpectedly, especially if you have a history of such issues or are taking sedatives.

  • Low Blood Pressure and Fainting: Apomorphine (Apokyn) can lead to a drop in blood pressure when transitioning from sitting or lying down to standing, increasing the risk of falls and fainting. This effect may occur more frequently with dose increases. To mitigate this risk, rise slowly and stabilize yourself with a solid object. Report any falls, fainting, or dizziness to your provider.

  • Hallucinations and Behavioral Changes: The medication can cause hallucinations, paranoia, delusions, confusion, and behavioral changes. If you have a history of mental health conditions, apomorphine (Apokyn) may not be suitable for you. Alert your provider if you experience any such symptoms; a dose adjustment may be necessary.

  • Impulsive Behavior: Apomorphine (Apokyn) may reduce impulse control, leading to urges such as excessive gambling, spending, or eating. If these behaviors negatively affect your life, consult your provider, as adjusting or discontinuing the medication may help.

  • Heart Problems: Some individuals have reported chest pain, heart attacks, and other cardiac issues after apomorphine (Apokyn) administration. Seek immediate medical attention if you experience chest pain, dizziness, or shortness of breath. Discuss your cardiac history with your provider to evaluate the appropriateness of this medication.

  • Painful Erections: Though rare, priapism (prolonged, painful erection) has been reported. If an erection lasts longer than four hours, seek medical assistance promptly.

Contraindications:

  • Do not use apomorphine (Apokyn) concurrently with ondansetron, granisetron, dolasetron, palonosetron, or alosetron, as these combinations pose significant health risks.
  • Apomorphine (Apokyn) is contraindicated in individuals with a sulfite allergy.

Always consult with your healthcare provider regarding any health conditions or medications you are taking to ensure the safe use of apomorphine (Apokyn).

Apokyn Side Effects

When using this medication, some individuals may experience mild side effects such as yawning, nausea or vomiting, drowsiness, and injection site reactions like redness, swelling, pain, or itching. These effects are generally not severe, but if they persist or worsen, it is advisable to consult a healthcare provider. Other common effects include dizziness, especially when standing up quickly, and slight confusion or hallucinations. Some people may also notice swelling in the arms or legs, increased sweating, headache, or trouble sleeping.

However, there are more serious side effects that require prompt medical attention. These include uncontrolled movements, significant mood changes such as confusion or hallucinations, muscle cramps, unusual strong urges, or swelling of extremities. Rarely, males may experience a prolonged erection lasting more than four hours, which is a medical emergency. In very serious instances, symptoms such as chest pain, shortness of breath, irregular heartbeat, or vision changes can occur, indicating potential heart problems. Additionally, some individuals have experienced falling asleep suddenly during daily activities, which can be dangerous. This risk may increase with alcohol or sedative medications.

Occasionally, the medication can cause a sudden drop in blood pressure, leading to dizziness or fainting. To reduce this risk, rise slowly from sitting or lying positions and avoid alcohol. A very serious allergic reaction is rare but requires immediate medical help if symptoms like rash, severe dizziness, or trouble breathing occur. Always contact a healthcare provider if any unexpected effects arise.

Apokyn Interactions

It's important to be aware of potential drug interactions when taking Apomorphine (Apokyn). This medication can interact with various other drugs and substances, which could affect how it works or increase the risk of side effects.

  1. Strong Interactions: You should avoid using Apomorphine with certain medications as it may not be safe. These include Alosetron, Bepridil, Cisapride, Dolasetron, Dronedarone, Granisetron, Mesoridazine, Ondansetron, Palonosetron, Piperaquine, Saquinavir, Sparfloxacin, Sulpiride, Terfenadine, Thioridazine, and Ziprasidone. Your doctor might need to choose an alternative treatment if you are taking any of these.

  2. Cautioned Use: There are other drugs where the combination with Apomorphine is typically not recommended unless necessary. If these medications are prescribed together, your doctor may adjust the dosage or frequency of use. These include a wide range of drugs, such as Alfuzosin, Alizapride, Amiodarone, Amisulpride, Amitriptyline, and many others. Be sure to provide your healthcare provider with a full list of the medications you are taking.

  3. Increased Side Effects: Combining Apomorphine with Nitroglycerin may heighten the risk of certain side effects, though the combination might be necessary for your treatment plan. In such cases, your doctor will carefully manage your doses.

For safe use of Apomorphine, always inform your healthcare provider about all the medications, supplements, and substances you are currently taking, including over-the-counter drugs, vitamins, and herbal products. This will help your doctor determine the best treatment plan and avoid harmful interactions.

Apokyn FAQs
What is APOKYN used for?

APOKYN is used to treat episodes of muscle stiffness, loss of muscle control, and sudden "off" periods in people with advanced Parkinson's disease. It helps improve movement and reduce the symptoms associated with these episodes.

Yes, APOKYN is available in the USA. It is a medication used to treat episodes of immobility in people with advanced Parkinson's disease.

The cost of APOKYN can be quite high, as it is a specialty medication used for specific medical conditions. Prices may vary based on insurance coverage, pharmacy, and location. Patients are encouraged to check with their insurance provider and pharmacy for the most accurate pricing information. Additionally, there may be patient assistance programs available to help offset the cost.

Apokyn is not classified as a controlled substance. It is a medication used to treat episodes of muscle stiffness and loss of muscle control in people with Parkinson's disease.

Inbrija and APOKYN are both medications used to manage symptoms in patients with Parkinson's disease, but they have different active ingredients and methods of administration. Inbrija contains levodopa and is administered via inhalation to provide quick relief from "off" episodes when oral medications are not effective. APOKYN, on the other hand, contains apomorphine and is administered via subcutaneous injection to provide rapid relief from similar "off" episodes. The choice between these medications depends on the patient's specific needs and the healthcare provider's recommendation.