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The safety information provided outlines crucial warnings and precautions associated with the use of apomorphine (Apokyn). It is essential to thoroughly understand these details and discuss any concerns with your healthcare provider.

• Severe Nausea and Vomiting: Nausea and vomiting are common side effects of apomorphine (Apokyn). Your healthcare provider may prescribe trimethobenzamide (Tigan) to manage these symptoms, as it was used in clinical trials. Avoid using other anti-nausea medications unless directed by your provider to prevent potential interactions.

• Sleepiness and Sudden Sleep Episodes: Apomorphine (Apokyn) can cause sudden sleep episodes without prior drowsiness. Until you know how the medication affects you, refrain from driving or engaging in activities that require full attention. Inform your provider if you experience excessive daytime sleepiness or fall asleep unexpectedly, especially if you have a history of such issues or are taking sedatives.

• Low Blood Pressure and Fainting: Apomorphine (Apokyn) can lead to a drop in blood pressure when transitioning from sitting or lying down to standing, increasing the risk of falls and fainting. This effect may occur more frequently with dose increases. To mitigate this risk, rise slowly and stabilize yourself with a solid object. Report any falls, fainting, or dizziness to your provider.

• Hallucinations and Behavioral Changes: The medication can cause hallucinations, paranoia, delusions, confusion, and behavioral changes. If you have a history of mental health conditions, apomorphine (Apokyn) may not be suitable for you. Alert your provider if you experience any such symptoms; a dose adjustment may be necessary.

• Impulsive Behavior: Apomorphine (Apokyn) may reduce impulse control, leading to urges such as excessive gambling, spending, or eating. If these behaviors negatively affect your life, consult your provider, as adjusting or discontinuing the medication may help.

• Heart Problems: Some individuals have reported chest pain, heart attacks, and other cardiac issues after apomorphine (Apokyn) administration. Seek immediate medical attention if you experience chest pain, dizziness, or shortness of breath. Discuss your cardiac history with your provider to evaluate the appropriateness of this medication.

• Painful Erections: Though rare, priapism (prolonged, painful erection) has been reported. If an erection lasts longer than four hours, seek medical assistance promptly.

Contraindications:

• Do not use apomorphine (Apokyn) concurrently with ondansetron, granisetron, dolasetron, palonosetron, or alosetron, as these combinations pose significant health risks.
• Apomorphine (Apokyn) is contraindicated in individuals with a sulfite allergy.

Always consult with your healthcare provider regarding any health conditions or medications you are taking to ensure the safe use of apomorphine (Apokyn).

When using this medication, some individuals may experience mild side effects such as yawning, nausea or vomiting, drowsiness, and injection site reactions like redness, swelling, pain, or itching. These effects are generally not severe, but if they persist or worsen, it is advisable to consult a healthcare provider. Other common effects include dizziness, especially when standing up quickly, and slight confusion or hallucinations. Some people may also notice swelling in the arms or legs, increased sweating, headache, or trouble sleeping.

However, there are more serious side effects that require prompt medical attention. These include uncontrolled movements, significant mood changes such as confusion or hallucinations, muscle cramps, unusual strong urges, or swelling of extremities. Rarely, males may experience a prolonged erection lasting more than four hours, which is a medical emergency. In very serious instances, symptoms such as chest pain, shortness of breath, irregular heartbeat, or vision changes can occur, indicating potential heart problems. Additionally, some individuals have experienced falling asleep suddenly during daily activities, which can be dangerous. This risk may increase with alcohol or sedative medications.

Occasionally, the medication can cause a sudden drop in blood pressure, leading to dizziness or fainting. To reduce this risk, rise slowly from sitting or lying positions and avoid alcohol. A very serious allergic reaction is rare but requires immediate medical help if symptoms like rash, severe dizziness, or trouble breathing occur. Always contact a healthcare provider if any unexpected effects arise.

It's important to be aware of potential drug interactions when taking Apomorphine (Apokyn). This medication can interact with various other drugs and substances, which could affect how it works or increase the risk of side effects.

1. Strong Interactions: You should avoid using Apomorphine with certain medications as it may not be safe. These include Alosetron, Bepridil, Cisapride, Dolasetron, Dronedarone, Granisetron, Mesoridazine, Ondansetron, Palonosetron, Piperaquine, Saquinavir, Sparfloxacin, Sulpiride, Terfenadine, Thioridazine, and Ziprasidone. Your doctor might need to choose an alternative treatment if you are taking any of these.

2. Cautioned Use: There are other drugs where the combination with Apomorphine is typically not recommended unless necessary. If these medications are prescribed together, your doctor may adjust the dosage or frequency of use. These include a wide range of drugs, such as Alfuzosin, Alizapride, Amiodarone, Amisulpride, Amitriptyline, and many others. Be sure to provide your healthcare provider with a full list of the medications you are taking.

3. Increased Side Effects: Combining Apomorphine with Nitroglycerin may heighten the risk of certain side effects, though the combination might be necessary for your treatment plan. In such cases, your doctor will carefully manage your doses.

For safe use of Apomorphine, always inform your healthcare provider about all the medications, supplements, and substances you are currently taking, including over-the-counter drugs, vitamins, and herbal products. This will help your doctor determine the best treatment plan and avoid harmful interactions.