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You might experience mild side effects such as diarrhea, nausea, vomiting, dizziness, lightheadedness, drowsiness, stomach upset, loss of appetite, trouble sleeping, headache, or dry mouth. These are generally manageable, but if they persist or worsen, consult your healthcare provider. Occasionally, this medication can cause saliva, urine, or sweat to darken, which is harmless but could stain clothing. To minimize dizziness, get up slowly from sitting or lying down.

In rare instances, some individuals may suddenly fall asleep during daily activities without prior drowsiness. If this happens, avoid driving or engaging in hazardous activities and discuss it with your doctor, as using alcohol or other drowsy-making medications can increase this risk.

Notify your doctor immediately if you experience serious side effects like uncontrolled movements, increased eye blinking, persistent diarrhea, vision changes, severe stomach pain, black stools, coffee ground-like vomit, muscle issues, kidney problems, mood changes, infection signs, unusual bleeding, fatigue, tingling, or strong urges like gambling or increased sexual desire.

Seek urgent medical attention for very serious side effects such as chest pain or fainting. Discontinuing the medication abruptly can rarely lead to neuroleptic malignant syndrome (NMS), a severe condition with symptoms like fever, muscle stiffness, confusion, sweating, or irregular heartbeat. Additionally, though rare, serious allergic reactions can occur, with symptoms like rash, swelling, severe dizziness, or breathing difficulties, requiring immediate medical help. If you notice any other effects, consult your healthcare provider.

Some medications may interact with this drug, including certain treatments for high blood pressure like methyldopa. Taking MAO inhibitors with this medication can lead to a serious, potentially fatal, interaction. It is important to avoid MAO inhibitors (such as isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, and tranylcypromine) while using this drug. Most MAO inhibitors should also not be used for two weeks before starting this medication. However, specific MAO inhibitors like rasagiline, safinamide, and selegiline may be taken with careful medical supervision. Consult your doctor about when to start or stop using this medication.

Inform your doctor or pharmacist if you are consuming other products that may cause drowsiness, including alcohol, marijuana (cannabis), antihistamines (like cetirizine, diphenhydramine), medications for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (like carisoprodol, cyclobenzaprine), and opioid pain relievers (such as codeine, hydrocodone).

Check all your medications' labels (like those for allergies or cough-and-cold) as they might contain ingredients that induce drowsiness. Discuss with your pharmacist how to use these products safely.

This drug may affect certain laboratory tests, such as urine catecholamine, glucose, and ketone tests, potentially leading to inaccurate results. Ensure that laboratory staff and all your healthcare providers are aware that you are using this medication.