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The medication Seglentis, which combines tramadol and celecoxib, carries several important safety warnings and precautions. It's essential to understand these risks to ensure safe and effective use.

• Risk of Abuse and Addiction: This medication can be addictive. To reduce this risk, take the smallest effective dose for the shortest duration. Do not alter the dosage without consulting your healthcare provider. Individuals with a history of substance use disorder or mental health conditions should be particularly cautious.

• Respiratory Depression: Tramadol, an opioid component, may cause severe breathing issues, particularly when starting the medication or increasing the dose. This risk is heightened when combined with alcohol or other medications that depress the central nervous system. Seek medical help immediately if you experience slow or shallow breathing.

• Opioid Overdose: Taking more than the prescribed dose can lead to a potentially fatal overdose. Keep this medication secure to prevent accidental ingestion by children, pets, or visitors. Symptoms like extreme drowsiness, slow heartbeat, or cold skin require emergency attention.

• Heart and Stroke Risks: Celecoxib, an NSAID in Seglentis, may increase the risk of heart attacks or strokes, especially with prolonged use or in individuals with pre-existing heart conditions. Immediate medical help is necessary if symptoms like chest pain or weakness on one side of the body occur.

• Gastrointestinal Bleeding: Celecoxib can cause stomach ulcers and bleeding, sometimes without warning. Urgent care is needed if you experience severe stomach pain, black stools, or vomit that looks like coffee grounds.

• Pregnancy Concerns: This medication may harm an unborn baby, particularly if used after 20 weeks of pregnancy. Pregnant individuals should discuss risks with their healthcare provider. Long-term use during pregnancy can also cause withdrawal symptoms in newborns.

• Drug Interactions: Both components of Seglentis can interact with other drugs, affecting its effectiveness or increasing side effects. Inform your healthcare team about all medications and supplements you are using.

• Specific Populations: Children under 12, and those 12-18 years old post-tonsil/adenoid surgery, should not use this medication. It is also not recommended for those with severe kidney or liver issues, or those who have recently had heart surgery.

• Allergic Reactions: Severe allergic reactions, including skin reactions, are possible. Discontinue use and seek medical attention if you experience swelling, difficulty breathing, or skin changes.

• Serotonin Syndrome: Tramadol can increase serotonin levels, risking serotonin syndrome, especially if combined with other serotonergic drugs. Symptoms like high fever or confusion require immediate medical attention.

• Withdrawal and Dependence: Long-term use can lead to physical dependence, with withdrawal symptoms occurring if the medication is stopped suddenly.

• Seizures and Other Risks: Tramadol may increase the risk of seizures, particularly in those with a history of seizures or when taken in high doses. It can also cause low adrenal hormone levels and changes in blood pressure.

Consult your healthcare provider for more information and guidance tailored to your health condition.

When taking this medication, some common side effects may occur, but they are usually mild and tend to diminish over time. These include nausea, dizziness, vomiting, headache, drowsiness, stomach upset, gas, constipation, and lightheadedness. To help prevent constipation, it is recommended to consume dietary fiber, stay hydrated, and engage in regular exercise. If you experience dizziness or lightheadedness, try to rise slowly from sitting or lying positions.

In some cases, more serious side effects can develop, which require immediate medical attention. These include dangerously slow breathing, symptoms of an opioid overdose (such as extreme drowsiness, cold or clammy skin), and signs of serotonin syndrome, which can present as a fast heartbeat, confusion, or muscle stiffness. Additionally, symptoms indicating heart problems, such as irregular heartbeat, chest pain, or swelling in the body, should be addressed urgently.

On rare occasions, this medication can cause severe health issues, including liver disease, which presents as persistent nausea, yellowing of the skin or eyes, and dark urine. Allergic reactions, although rare, require prompt medical help if symptoms like rash, swelling, or difficulty breathing occur. If you notice any other unusual symptoms or have concerns about side effects not listed, it's important to reach out to your healthcare provider.

This medication may interact with several other drugs, leading to increased risks or altered effects. It can interact with ACE inhibitors (e.g., captopril, lisinopril), aliskiren, angiotensin II receptor blockers (e.g., valsartan, losartan), cidofovir, lithium, naltrexone, certain pain medications (e.g., butorphanol, nalbuphine, pentazocine), samidorphan, and diuretics like furosemide. Combining this medication with others that can cause bleeding, such as anti-platelet medications like clopidogrel or blood thinners like warfarin, dabigatran, and enoxaparin, may raise your bleeding risk.

Be cautious with medications containing pain relievers or fever reducers, like aspirin or NSAIDs (e.g., naproxen, ibuprofen), as these are similar to celecoxib and can heighten side effect risks. If prescribed low-dose aspirin (81-162 mg per day) for heart attack or stroke prevention, continue unless instructed otherwise by your doctor.

Avoid MAO inhibitors (e.g., isocarboxazid, linezolid, phenelzine) during treatment and for two weeks prior, due to the potential for serious interactions. Consult your doctor on timing for starting or stopping this medication.

The risk of serotonin syndrome increases if taken with drugs that elevate serotonin levels, such as certain antidepressants (e.g., SSRIs like fluoxetine, SNRIs like duloxetine), St. John's wort, or MDMA. This risk may be higher when starting or increasing doses of these medications.

Some drugs can influence how this medication is eliminated from the body, affecting its efficacy. These include azole antifungals (e.g., itraconazole), macrolide antibiotics (e.g., erythromycin), quinidine, rifamycins (e.g., rifampin), ritonavir, and seizure medications (e.g., carbamazepine).

Taking this medication with others that cause drowsiness or breathing issues may increase these side effects. Inform your doctor if you use opioids (e.g., codeine, hydrocodone), alcohol, cannabis, sleep or anxiety medications (e.g., alprazolam, zolpidem), muscle relaxants (e.g., carisoprodol), or antihistamines (e.g., diphenhydramine).

Double-check labels on all medications, including allergy or cold products, as they might contain ingredients that cause drowsiness. Consult your pharmacist for safe use.

Lastly, this medication may affect lab test results, such as amylase/lipase levels, potentially leading to inaccuracies. Ensure all healthcare providers and lab personnel are aware you are taking this drug.