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Naproxen, a type of nonsteroidal anti-inflammatory drug (NSAID), is associated with certain risks that users should be aware of. While it can be effective for pain relief, it may rarely increase the likelihood of a heart attack or stroke. This risk is present at any point during use but may be heightened with prolonged consumption, particularly in older adults or individuals with existing heart conditions or risks factors such as smoking, family history, high blood pressure, or diabetes. It is important to avoid taking naproxen immediately before or after undergoing heart bypass surgery (CABG).

Additionally, naproxen can infrequently cause severe, potentially life-threatening bleeding in the stomach or intestines, which may occur without prior symptoms. This risk is also elevated in older individuals.

Be vigilant for the following rare but serious side effects and seek immediate medical attention if they occur:

• Persistent stomach or abdominal pain.
• Black or tarry stools.
• Vomit resembling coffee grounds.
• Pain in the chest, jaw, or left arm.
• Shortness of breath.
• Unusual sweating.
• Confusion or weakness on one side of the body.
• Difficulty speaking or sudden changes in vision.

Before using naproxen, discuss its benefits and potential risks with your doctor or pharmacist, especially if you have concerns about its effects due to any pre-existing conditions or other medications you may be taking.

You might experience mild side effects like an upset stomach, nausea, heartburn, headache, drowsiness, or dizziness. These are generally not concerning but should be reported to your healthcare provider if they persist or worsen. Monitoring your blood pressure is important, as this medication might cause an increase. Inform your healthcare provider if you notice a rise in your blood pressure.

Be alert for any serious side effects, which require immediate medical attention. These include easy bruising or bleeding, difficulty swallowing, changes in hearing (such as ringing in the ears), mood or mental changes, signs of kidney problems (like changes in urine output), vision changes, or symptoms of heart failure (such as swelling in the ankles or feet, unusual tiredness, or sudden weight gain).

In very rare cases, this medication can lead to severe liver disease, which may be life-threatening. Seek urgent medical care if you experience persistent nausea or vomiting, loss of appetite, dark urine, stomach or abdominal pain, or yellowing of the eyes or skin. Additionally, although a serious allergic reaction is rare, it is vital to get immediate help if you experience symptoms like fever, swollen lymph nodes, rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing.

This summary does not cover all possible side effects. If you experience any other unusual effects, contact your healthcare provider for advice.

Some medications can interact with this drug, potentially affecting how it works or increasing side effects. These include:

• Blood Pressure and Heart Medications: Aliskiren, ACE inhibitors (like Captopril, Lisinopril), and angiotensin II receptor blockers (such as Valsartan, Losartan).
• Other Drugs: Cidofovir, corticosteroids (e.g., Prednisone), Lithium, and diuretics (also known as "water pills," such as Furosemide).

Important Note: Avoid taking this medication with antacids or drugs that reduce stomach acid, including Famotidine, ranitidine, and proton pump inhibitors like Omeprazole. These can disrupt the drug's enteric coating, leading to premature release and increased side effects.

This medication can also heighten bleeding risk if combined with other drugs that cause bleeding. Examples include anti-platelet medications like Clopidogrel and anticoagulants or "blood thinners" such as Dabigatran, Enoxaparin, or Warfarin.

It's important to check labels on both prescription and nonprescription drugs, as many pain relievers and fever reducers, like Aspirin and NSAIDs (such as Celecoxib, Ibuprofen, or Ketorolac), are similar to naproxen and can increase side effects when used together. However, if your healthcare provider has advised you to take low-dose aspirin (81-162 mg daily) for heart attack or stroke prevention, continue as directed unless advised otherwise. Be aware that daily naproxen use may reduce aspirin's effectiveness in preventing heart issues; discuss alternatives for pain or fever management with your doctor.

Lastly, this medication might interfere with certain lab tests, leading to inaccurate results. Ensure that all your healthcare providers and lab technicians know you are using this drug.