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Methadone is associated with significant safety concerns, including the potential for abuse and addiction, which may lead to overdose and potentially fatal outcomes. It can also cause severe respiratory and cardiac complications. To minimize these risks, it is crucial to adhere to your doctor’s instructions by using the lowest effective dose for the shortest duration possible. Avoid increasing your dose or taking the medication more frequently than prescribed.

• Consider having naloxone on hand for opioid overdose emergencies and educate family members on recognizing and managing an overdose.
• The risk of serious breathing or cardiac issues is heightened at the start of methadone treatment, during a transition from another opioid, after dose adjustments, or when taking an incorrect dose.
• Respiratory issues may not manifest immediately following a dose, and cardiac complications can occur even at lower doses, although they are more common with higher doses used for pain management.
• Combining methadone with alcohol or other substances that induce drowsiness or respiratory depression significantly increases the risk of severe side effects, including death.
• Methadone’s effectiveness can be influenced by other medications that alter its elimination from the body, so be informed about drugs to avoid while on methadone.
• Seek immediate medical assistance if you experience symptoms such as slow or shallow breathing, extreme lightheadedness, severe drowsiness or dizziness, difficulty waking, rapid or irregular heartbeat, or fainting.

Store methadone securely to prevent theft, misuse, or accidental ingestion. In case of accidental ingestion, seek medical attention immediately.

Women of childbearing age should discuss potential risks and benefits with their healthcare provider before using methadone. Pregnancy may alter the drug's concentration in the body. Use methadone during pregnancy only if absolutely necessary, as it may slightly increase the risk of birth defects during the first two months and cause harm if used in high doses or for extended periods near delivery. Infants born to mothers who have used methadone long-term may suffer from severe withdrawal symptoms. Notify a healthcare provider immediately if a newborn exhibits symptoms like persistent crying, slow or shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight.

When taking this medication, you might experience some common side effects such as nausea, vomiting, constipation, lightheadedness, dizziness, dry mouth, drowsiness, or sweating. These effects often improve with time as your body adjusts to the medication. To manage constipation, consider eating more fiber, staying hydrated, and engaging in regular exercise. A laxative might also be helpful; consult with a pharmacist to determine the appropriate type. To minimize dizziness and lightheadedness, rise slowly from sitting or lying down.

While many individuals do not encounter serious side effects, it is important to be vigilant. Notify your healthcare provider immediately if you experience severe side effects like interrupted breathing during sleep, significant mental or mood changes, abdominal pain, or difficulty urinating. Additionally, signs of adrenal gland issues, such as a loss of appetite, unusual fatigue, or weight loss, should be addressed promptly with medical advice.

In rare instances, very serious reactions can occur, such as seizures or severe drowsiness that makes waking difficult. Seek urgent medical attention if these occur. Allergic reactions to this medication are uncommon but require immediate care if symptoms such as rash, swelling, severe dizziness, or breathing troubles arise. Always consult your healthcare provider if you notice any other side effects not listed here.

Certain medications can interact with this drug, impacting its effectiveness or increasing the risk of side effects. Pain medications like butorphanol, nalbuphine, and pentazocine, as well as naltrexone and samidorphan, may cause interactions. Additionally, taking MAO inhibitors—such as isocarboxazid, linezolid, and others—with this drug can lead to dangerous, potentially fatal reactions. Avoid MAO inhibitors during treatment and typically for two weeks before and after using this medication. Consult your doctor for specific timing.

Some drugs, including St. John's wort, azole antifungals (like itraconazole), macrolide antibiotics (like erythromycin), rifamycins (such as rifampin), and certain seizure medications (such as carbamazepine), can alter how methadone is processed in your body, affecting its function.

Taking this medication with other substances that cause drowsiness or breathing issues, such as other opioids (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (like alprazolam, lorazepam), muscle relaxants (such as carisoprodol), and certain antihistamines (like cetirizine, diphenhydramine), may heighten the risk of severe side effects like slow breathing and extreme drowsiness. Always check your medication labels for ingredients that may induce drowsiness, and consult your pharmacist about safe usage.

This drug may affect lab test outcomes (such as amylase/lipase levels), possibly leading to incorrect results. Inform lab personnel and all your healthcare providers that you are using this medication.