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This information outlines important safety considerations for the use of cinacalcet (Sensipar). It is crucial to understand these risks and precautions before starting the medication. Always consult your healthcare provider if you have any questions or concerns.

• Low Calcium Levels (Hypocalcemia): Cinacalcet may cause a significant drop in calcium levels, which could be life-threatening. Those using other medications that also lower calcium levels are at heightened risk. Symptoms of low calcium include muscle cramps, confusion, tingling in the fingers or lips, seizures, and irregular heartbeats. Regular laboratory tests are necessary to monitor your calcium levels while taking this medication. Inform your healthcare provider if you have a history of heart issues or seizures.

• Upper Gastrointestinal Bleeding: There is a risk of stomach bleeding associated with cinacalcet. This risk may increase if you have a history of ulcers or other stomach issues. Contact your healthcare provider immediately if you experience persistent nausea or vomiting, blood in vomit or stool, black, tarry stools, or abdominal pain.

• Bone Health: Cinacalcet can affect bone health by lowering parathyroid hormone (PTH) levels too much. Regular monitoring of PTH levels through lab tests is necessary to prevent bone problems.

• Heart Complications: For individuals with a history of heart conditions, cinacalcet may cause low blood pressure or abnormal heart rhythms. Signs to watch for include irregular heartbeats, difficulty breathing, limb swelling, sudden weight gain, mental confusion, or persistent fatigue. Notify your healthcare provider if you experience any of these symptoms.

Contraindications:

• Severely Low Calcium Levels: Do not use cinacalcet if you already have very low calcium levels, as it could pose serious health risks. Consult your healthcare provider to evaluate your condition before beginning treatment.

Always follow your healthcare provider's instructions and report any unusual symptoms while taking cinacalcet.

When taking this medication, some individuals may experience common side effects such as nausea, vomiting, and diarrhea. These are often mild and temporary, but if they persist or worsen, it is important to consult a healthcare professional. Other reported side effects include stomach pain, muscle aches, dizziness, poor appetite, headache, and back pain. While these are generally manageable, any concerns should be discussed with a healthcare provider.

More serious side effects, though rare, require immediate medical attention. These include symptoms of very low calcium levels such as severe muscle pain and spasms, tingling sensations, or seizures. Additionally, signs of a stomach bleed like persistent vomiting, blood in vomit or stool, black or tarry stools, and severe stomach pain are critical and should be addressed urgently. Heart-related issues such as abnormal heartbeats, trouble breathing, sudden weight gain, swelling of arms and legs, or confusion are also serious and necessitate prompt medical care.

In extremely rare cases, a severe allergic reaction may occur, characterized by rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing. If any of these symptoms arise, immediate medical assistance is crucial. While this list covers many potential side effects, it is not exhaustive, and any other unusual effects should be reported to a healthcare provider.

When taking Cinacalcet (Sensipar), be aware of potential interactions with other medications. Inform your doctor and pharmacist about all the medications, including prescriptions, over-the-counter drugs, vitamins, and supplements you are currently using. One specific interaction to note is with thioridazine; if switching to etelcalcetide, stop thioridazine at least seven days prior to beginning etelcalcetide to avoid increased risk of side effects, particularly low calcium levels.

Additionally, avoid using Cinacalcet with eliglustat, as this is generally not recommended. There are also medications where concurrent use with Cinacalcet is usually discouraged but may be necessary; these include brexpiprazole, clozapine, codeine, dihydrocodeine, donepezil, doxorubicin (including its hydrochloride liposome form), fluoxetine, nebivolol, tamoxifen, and tramadol. In such cases, your doctor might adjust the dosages or usage frequency.

For medications like desipramine and ketoconazole, using them with Cinacalcet can increase the risk of side effects, but this combination might still be the best treatment option. Your healthcare provider may modify the doses or how often you take these medicines to ensure safety and efficacy.