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This medication has specific safety warnings that are crucial to understand before starting treatment. Please review these points carefully and consult with your healthcare provider if you have any questions or concerns.

• Slowed Heartbeat: Donepezil (Aricept) may reduce your heart rate, potentially causing fainting. To minimize this risk, consider taking the medication at bedtime. Notify your healthcare provider if you experience falls or dizziness, as a dosage adjustment may be necessary.

• Nausea and Vomiting: Initial use or dosage increases of donepezil (Aricept) can lead to nausea, vomiting, and diarrhea, usually subsiding after a few weeks. If these symptoms are severe or prevent daily medication use, inform your healthcare provider. The likelihood of experiencing these side effects is higher with increased doses or if you weigh less than 55 kg (121 lbs).

• Stomach Ulcers and Bleeding: Donepezil (Aricept) can increase stomach acid production, raising the risk of ulcers and bleeding, especially at the 23 mg dose. This risk is further elevated if you are using NSAIDs, which are often present in over-the-counter medications for pain and cold symptoms. Avoid combining these with donepezil (Aricept) and consult your provider if you experience worsening stomach discomfort, heartburn, or indigestion, particularly if you have a history of ulcers or are on the maximum dose.

• Weight Loss: Usage of donepezil (Aricept) may lead to weight loss, with about 5% of those on a 23 mg dose and 3% on a 10 mg dose reporting this issue. The higher dose group also had more instances of losing 7% or more of their body weight. Discuss any concerns regarding this side effect with your healthcare provider, particularly if you are on a higher dose.

There are no specific contraindications provided for donepezil (Aricept). Please ensure to keep your healthcare provider informed of any unusual symptoms or concerns during your treatment.

Common side effects:

• Nausea
• Diarrhea
• Headache
• Trouble sleeping
• Pain
• Dizziness
• Muscle cramps
• Tiredness
• Vomiting
• Loss of appetite

Less common but important to monitor:

• Bruising
• Sleepiness
• Fainting
• Depression
• Abnormal dreams
• Weight loss
• Arthritis
• Increased frequency of urination

Serious side effects:

• Difficulty urinating
• Severe stomach or abdominal pain
• Black stools
• Vomit with a coffee ground appearance
• Seizures
• Slow, fast, or irregular heartbeat
• Severe dizziness
• Fainting
• Allergic reaction (rash, itching/swelling, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Bepridil
• Cisapride
• Dronedarone
• Fluconazole
• Ketoconazole
• Mesoridazine
• Pimozide
• Piperaquine
• Posaconazole
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone
• Aspirin
• Ibuprofen
• Naproxen

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Abiraterone Acetate
• Amiodarone
• Aripiprazole
• Ramelteon