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Carbamazepine has been associated with the development of rare but potentially life-threatening skin reactions. Those of Asian or South Asian descent may have a higher risk. Prior to starting this medication, your healthcare provider might conduct a blood test to assess your risk level. If increased risk is identified, a discussion regarding the potential risks and benefits of carbamazepine and alternative treatments will follow. Typically, these skin reactions emerge during the initial months of therapy. Immediate medical attention is crucial if symptoms such as a skin rash, blisters, peeling, itching, or swelling occur. For further information, consult your doctor or pharmacist.

Additionally, carbamazepine has been infrequently linked to severe blood disorders, namely aplastic anemia and agranulocytosis. Regular monitoring of your blood counts by your doctor is essential to mitigate these risks. It is important to attend all scheduled medical and laboratory appointments. Seek urgent medical care if you experience any of the following uncommon yet severe side effects: persistent sore throat, fever, swollen lymph nodes, unusual fatigue, shortness of breath, or easy bleeding/bruising.

You might experience nausea, vomiting, dizziness, drowsiness, constipation, dry mouth, or a sense of unsteadiness while taking this medication. These are common side effects and are usually mild. If they persist or worsen, it's important to inform your healthcare provider. Occasionally, you might notice an empty tablet shell in your stool, which is harmless, as the medication has already been absorbed.

While serious side effects are less common, they require prompt attention. Contact your healthcare provider if you experience severe headaches, persistent nausea or vomiting, appetite loss, stomach pain, yellowing of the skin or eyes, dark urine, or any signs of liver issues. Kidney problems might manifest as changes in urine output. Other serious side effects include mouth sores, fainting, irregular heartbeat, unusual eye movements, vision changes, joint pain, swelling of the extremities, or numbness in the hands or feet. Be alert for symptoms of low sodium levels, such as severe drowsiness, confusion, or seizures.

Some individuals taking anticonvulsants may experience mood changes, including depression or suicidal thoughts. If you or someone close to you notices unusual mood changes or thoughts of self-harm, seek medical help immediately. Although rare, serious allergic reactions can occur. Seek immediate medical assistance if you experience a rash, itching, swelling, severe dizziness, or difficulty breathing.

This summary does not cover all possible side effects. If you notice any other unexpected effects, reach out to your healthcare provider for guidance.

Certain medications may interact with this drug. These include specific azole antifungals like isavuconazonium and Voriconazole, and Orlistat. Using MAO inhibitors with this medication can lead to a severe, potentially life-threatening reaction. It is important to avoid MAO inhibitors such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine during treatment. Generally, MAO inhibitors should also not be used for two weeks prior to starting this medication. Consult your doctor about when to begin or discontinue use of this medication.

Some drugs can alter how carbamazepine is removed from your body, potentially impacting its effectiveness. These drugs include macrolide antibiotics like Erythromycin, rifamycins like Rifabutin, and St. John's wort. Conversely, carbamazepine may expedite the elimination of other medications from your body, influencing their efficacy. Affected drugs include artemether/lumefantrine, certain anticoagulants like apixaban and Rivaroxaban, calcium channel blockers such as Nifedipine and Nimodipine, Nefazodone, nirmatrelvir, HIV NNRTIs like Efavirenz, Etravirine, rilpivirine, Praziquantel, and ranolazine.

This medication might reduce the effectiveness of hormonal birth control methods, such as pills, patches, or rings, which could lead to pregnancy. Discuss with your doctor or pharmacist whether you should use additional reliable birth control methods while taking this medication. Inform your doctor if you experience any new spotting or breakthrough bleeding, as these may indicate that your birth control is not functioning properly.

Inform your doctor or pharmacist if you are using other substances that cause drowsiness, including alcohol, marijuana (cannabis), antihistamines like Cetirizine and diphenhydramine, sleep or anxiety medications such as Alprazolam, Diazepam, and Zolpidem, muscle relaxants like Carisoprodol and Cyclobenzaprine, and opioid pain relievers like codeine and hydrocodone. Check the labels of all your medications, including those for allergies or cough-and-cold, since they may contain ingredients that can cause drowsiness. Consult your pharmacist about how to safely use these products.

Additionally, this medication may interfere with certain lab tests, such as those assessing thyroid function and some pregnancy tests, potentially leading to incorrect results. Ensure that lab personnel and all your healthcare providers are aware of your use of this drug.