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Carbamazepine carries a rare risk of severe, potentially life-threatening skin reactions. Certain ethnic groups, particularly individuals of Asian or South Asian descent, may be more susceptible. Prior to starting treatment, your doctor might recommend a blood test to evaluate your risk level. If you're identified as having a higher risk, your healthcare provider will discuss the pros and cons of using carbamazepine and possible alternative treatments. These skin reactions typically appear within the initial months of therapy. Seek immediate medical attention if you notice symptoms like skin rash, blistering, peeling, itching, or swelling. Consult your doctor or pharmacist for further information.

Additionally, carbamazepine has infrequently been associated with severe blood disorders, such as aplastic anemia and agranulocytosis. Regular blood count monitoring by your doctor is essential to help prevent these side effects. Ensure you attend all scheduled medical and laboratory appointments. Urgent medical care is necessary if you experience symptoms like persistent sore throat, fever, swollen lymph nodes, unusual fatigue, shortness of breath, or easy bruising or bleeding.

You may experience some common side effects such as nausea, vomiting, dizziness, drowsiness, constipation, dry mouth, or a feeling of unsteadiness. These effects are usually mild, but if they persist or worsen, it's important to seek advice from a healthcare professional. Many individuals using this medication do not experience severe side effects, so there's generally little cause for concern.

However, be aware of more serious side effects that require immediate medical attention. These include persistent or severe headaches, symptoms of liver issues like unstoppable nausea or vomiting, loss of appetite, stomach pain, jaundice, and dark urine. Watch for signs of kidney problems, such as changes in urination, and mouth sores. Other serious symptoms can include fainting, irregular heartbeat, unusual eye movements, blurred vision, joint pain, swelling in the ankles or feet, pain and swelling in the arms or legs, and numbness or tingling in the extremities. Low sodium levels in the blood might manifest as extreme drowsiness, confusion, seizures, or mood changes.

For those using anticonvulsants, there's a risk of depression, suicidal thoughts, or other mental health issues. It's crucial to report any sudden mood changes or thoughts of self-harm to a healthcare provider promptly. Although rare, a serious allergic reaction could occur, characterized by rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing. Seek emergency medical help if these symptoms appear. This list doesn't cover all possible side effects, so if you notice anything unusual, consult your healthcare provider.

This medication can interact with several other products, including certain azole antifungal drugs like isavuconazonium and Voriconazole, as well as Orlistat. It's important to avoid using MAO inhibitors, such as isocarboxazid, Linezolid, and others, with this medication, as it can lead to a severe, potentially life-threatening reaction. MAO inhibitors should also not be taken for two weeks before starting this medication. Consult your doctor for guidance on when to begin or discontinue use of this medication.

Certain drugs can influence how carbamazepine is eliminated from your body, potentially altering its effectiveness. These include macrolide antibiotics like Erythromycin, rifamycins such as Rifabutin, and St. John's wort. Additionally, carbamazepine can speed up the removal of other drugs, which might affect their effectiveness. Some affected drugs include artemether/lumefantrine, blood clot prevention medications like apixaban, certain calcium channel blockers, and others.

This medication may reduce the effectiveness of hormonal birth control methods like pills, patches, or rings, increasing the risk of pregnancy. Discuss with your healthcare provider whether additional birth control methods are needed. Report any unusual spotting or breakthrough bleeding to your doctor, as these may indicate reduced birth control efficacy.

Be sure to inform your doctor if you are taking other products that cause drowsiness, such as alcohol, cannabis, antihistamines, sleep or anxiety medications, muscle relaxants, and opioid pain relievers. Check medicine labels for ingredients that may cause drowsiness, and consult your pharmacist about using such products safely.

This medication might affect certain lab tests, including thyroid function or pregnancy tests, potentially leading to inaccurate results. Ensure all your healthcare providers and lab personnel are aware of your medication use.