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This medication requires careful consideration due to its potential risks and necessary precautions. Below is a summary of critical safety information and warnings that should be reviewed and discussed with your healthcare provider:

• Liver Problems: Maraviroc (Selzentry) may lead to severe liver issues, especially within the first month of treatment. Regular blood tests will be conducted by your HIV specialist to monitor liver function. Be vigilant for symptoms such as persistent nausea/vomiting, rash, yellowing of the eyes or skin, dark urine, and extreme fatigue. An allergic reaction often precedes liver complications. Individuals with hepatitis B or C, or a history of liver issues, are at greater risk.

• Severe Skin and Allergic Reactions: This medication can cause serious skin reactions, which can require hospitalization. The risk increases if you are taking other drugs that may cause allergic reactions. Seek medical attention immediately if you experience a rash, blistering skin, painful sores, swelling, or breathing difficulties.

• Heart Issues and Low Blood Pressure: Some patients have experienced heart attacks while on maraviroc (Selzentry). It’s crucial to inform your healthcare provider about any pre-existing heart or kidney conditions. Symptoms like chest pain, excessive sweating, nausea, or dizziness warrant urgent medical care.

• Overactive Immune System: The medication can alter your immune response, leading to immune reconstitution syndrome. This might result in your immune system attacking normal cells. Report any new symptoms such as fever, hair loss, or sweating to your healthcare team.

• Serious Infections: Maraviroc (Selzentry) can reduce your body’s ability to combat infections. The risk is heightened if combined with other medications like corticosteroids. Notify your healthcare provider of any signs of infection, such as fever, cough, or sore throat.

• Drug Interactions: Some medications can affect the clearance of maraviroc (Selzentry) from your body, influencing its effectiveness and side effects. Discuss all your current medications with your healthcare provider to avoid harmful interactions.

Contraindications: Avoid using this medication if you have severe kidney problems and are on specific interacting medications (e.g., clarithromycin, Triumeq). Always consult your healthcare provider if you fall into this category before starting treatment.

In case of overdose, seek emergency medical attention immediately.

Common side effects:

• Cough
• Dizziness
• Fever
• Upper respiratory tract infection
• Trouble sleeping
• Changes in appetite
• Constipation
• Herpes infection

Less common but important to monitor:

• Pink eye
• Inflamed hair follicles
• Ear infections
• Pins and needles sensation
• Nerve pain
• Muscle pain
• Mood changes
• Congestion

Serious side effects:

• Liver problems (nausea, vomiting, lack of appetite, pain in the right side of the stomach, yellowing of the skin or eyes, dark urine)
• Severe allergic reactions (facial swelling, hives, rash, itchy skin, blistering or peeling of skin, body aches, trouble breathing, mouth sores)

Interactions with high risk of serious adverse effects and should be avoided:

• Atazanavir
• Boceprevir
• Carbamazepine
• Clarithromycin
• Cobicistat
• Conivaptan
• Darunavir
• Delavirdine
• Efavirenz
• Enzalutamide
• Etravirine
• Fosamprenavir
• Fosphenytoin
• Idelalisib
• Indinavir
• Itraconazole
• Ketoconazole
• Lopinavir
• Nefazodone
• Nelfinavir
• Phenobarbital
• Phenytoin
• Posaconazole
• Primidone
• Rifampin
• Ritonavir
• Saquinavir
• St. John's Wort
• Telaprevir
• Telithromycin
• Voriconazole

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Abametapir
• Cabotegravir
• Capmatinib
• Ceritinib
• Duvelisib
• Fosnetupitant
• Ivosidenib
• Larotrectinib
• Lasmiditan
• Lefamulin
• Lorlatinib
• Lumacaftor
• Netupitant
• Pexidartinib
• Venetoclax