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The following information outlines important safety precautions and warnings related to the use of eletriptan (Relpax). It is crucial to review these details and discuss any concerns with your healthcare provider.

• Cardiovascular Risks: There have been rare instances of serious heart issues, including heart attacks and irregular heart rhythms, occurring shortly after taking eletriptan (Relpax). Additionally, this medication may cause dangerously high blood pressure levels. Individuals with a history of heart problems, those over the age of 65, individuals with obesity, diabetes, high blood pressure, or those who smoke should exercise caution.

• Stroke and Brain Injury: Eletriptan (Relpax) and similar triptan medications have been associated with life-threatening strokes and brain bleeds. Therefore, individuals with a history of stroke should not use this medication. Ensure your healthcare provider is aware of your medical history.

• Vascular Concerns: This medication can cause severe narrowing of blood vessels, potentially leading to serious gastrointestinal issues, vision disturbances, and sensory changes in extremities. Symptoms may resemble Raynaud's phenomenon, such as color changes in the hands and feet. Discontinue use and consult your healthcare provider if these symptoms occur.

• Medication Overuse Headache: Frequent or excessive use of eletriptan (Relpax) can lead to increased headache frequency or intensity. If you find yourself using migraine medication more than nine days per month or experiencing over three migraines monthly while on this medication, inform your healthcare provider to explore alternative treatments.

• Serotonin Syndrome: Although rare, eletriptan (Relpax) can cause serotonin syndrome, a potentially life-threatening condition due to excessive serotonin in the brain. The risk increases if taken with other serotonin-boosting medications.

Contraindications: Eletriptan (Relpax) should not be used in the following conditions due to potential severe health risks. Consult your healthcare provider if any of these apply:

• Coronary artery disease or history of heart attack
• Coronary artery vasospasm (e.g., Prinzmetal's angina)
• Certain arrhythmias, such as Wolff-Parkinson-White syndrome
• History of stroke or transient ischemic attack
• Hemiplegic or basilar migraines
• Uncontrolled high blood pressure
• Peripheral vascular disease
• Ischemic bowel disease
• Recent use of ergot-containing medications or other triptans (within 24 hours)
• Recent use of medications such as ketoconazole, itraconazole, clarithromycin, nefazodone, ritonavir, or nelfinavir (within 72 hours)

Please ensure that you are fully informed about the potential risks and contraindications associated with eletriptan (Relpax) and consult your healthcare provider for guidance tailored to your health needs.

Common side effects:

• dizziness
• sleepiness
• nausea
• body weakness
• tingling sensation in the arms or legs
• headaches
• dry mouth
• flushing sensation
• heartburn
• stomach discomfort
• stomach pain
• stomach cramps
• stomach pressure
• feelings of tightness in the chest or throat
• difficulty swallowing

Serious side effects:

• chest pain
• trouble breathing
• irregular heartbeat
• severe headaches
• sudden weakness on one side of the body
• confusion
• changes in speech or vision
• serotonin syndrome
• fast heartbeat
• severe dizziness
• sweating
• muscle twitching
• hallucinations
• severe allergic reactions
• hives
• swelling of the face or throat

Interactions with high risk of serious adverse effects and should be avoided:

• Cobicistat
• Nefazodone
• Ribociclib
• Ritonavir
• Azole antifungals (e.g., Ketoconazole, Itraconazole)
• Macrolide antibiotics (e.g., Clarithromycin, Erythromycin)
• HIV protease inhibitors (e.g., nelfinavir)
• Ergotamine medications (e.g., Dihydroergotamine)
• Other triptan drugs (e.g., Sumatriptan, Rizatriptan)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• SSRIs (e.g., Fluoxetine, paroxetine)
• SNRIs (e.g., Duloxetine, Venlafaxine)
• MDMA
• St. John's wort