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This medication requires careful attention to safety and potential risks. It is important to understand the possible effects and precautions to take while using this product. Below are essential safety considerations for patients and healthcare professionals:

• High Potassium Levels (Hyperkalemia): This medication can lead to elevated potassium levels, which may be dangerous. The risk is higher for older adults and individuals with kidney disease, diabetes, or serious illnesses. It is crucial to monitor potassium levels regularly. Symptoms of high potassium include muscle weakness, nausea, slow or irregular heartbeat, and numbness or tingling in the skin. Seek medical attention immediately if these symptoms occur.

• Electrolyte, Blood Sugar, and Cholesterol Changes: The medication may alter the levels of electrolytes such as sodium, potassium, and magnesium, as well as blood sugar and cholesterol. Regular blood tests may be necessary to monitor these changes. Alert your healthcare provider if you experience symptoms like rapid heartbeat, fatigue, muscle cramps, nausea, vomiting, or decreased urination, as these may indicate imbalances.

• Lupus Risk: Though rare, some patients on thiazide diuretics, like hydrochlorothiazide in this medication, have developed lupus, or experienced worsening of existing lupus. Report any symptoms such as a facial rash, extreme fatigue, or joint pain to your healthcare provider.

• Contraindications: Do not use this medication if you have high potassium levels (over 5.5 mEq/L), are taking substances that increase potassium, have anuria (no urine production), suffer from kidney issues (especially due to diabetes), or have allergies to sulfa drugs or potassium-sparing diuretics. Always consult your healthcare provider if any of these conditions apply to you.

It is vital to discuss your full medical history and current medications with your healthcare provider before starting treatment to ensure safe use of this medication.

Common side effects:

• Headache
• Dizziness
• Nausea
• Vomiting
• Lower appetite
• Stomach or abdominal pain
• Gas
• Diarrhea
• Rash

Less common but important to monitor:

• Feeling tired
• Irregular heartbeat
• Shortness of breath
• Itchiness
• Gout
• Dehydration
• Unusual dry mouth or thirst
• Muscle cramps or weakness
• Confusion

Serious side effects:

• Severe allergic reactions
• Swelling of the lips, tongue, throat, or face
• Trouble breathing
• High potassium levels
• Persistent nausea
• Muscle weakness
• Abnormal heartbeat
• Fainting
• Signs of liver problems
• Joint pain
• Vision changes
• Signs of kidney issues

Interactions with high risk of serious adverse effects and should be avoided:

• Dofetilide
• Eplerenone
• Triamterene

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Benazepril
• Captopril
• Ibuprofen
• Lithium
• Losartan
• Valsartan
• Naproxen