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The safety and warning information for Cresemba (isavuconazonium) is crucial to ensure its safe and effective use. Please read the following details carefully and consult your healthcare provider with any questions or concerns.

• Liver Health Concerns: Cresemba can sometimes cause liver irritation, which is usually manageable without discontinuing the medication. However, in rare cases, it may lead to severe liver problems. Your doctor may conduct blood tests before and during treatment to monitor your liver function. It is advisable to limit or avoid alcohol consumption as it can exacerbate liver issues. Seek immediate medical help if you notice symptoms such as jaundice (yellowing of skin or eyes), unusual stool color, dark urine, abdominal swelling, stomach pain, or confusion. Your doctor may decide to stop the medication if liver health is compromised.

• Allergic Reactions and Skin Concerns: There have been reports of infusion-related allergic reactions. If you experience difficulty breathing, chills, or dizziness during an infusion, inform your healthcare provider immediately, as they may need to halt the infusion.

• Pregnancy Precautions: Cresemba should not be used during pregnancy due to the risk of developmental issues in the fetus. Women who can become pregnant should use contraception during treatment and continue for at least 28 days after the last dose. Inform your healthcare provider if you are pregnant or planning to become pregnant.

• Drug Interactions: Cresemba may interact with certain medications, leading to reduced effectiveness or increased risk of side effects. Avoid using Cresemba with medications such as rifampin (Rifadin) and phenytoin (Dilantin), as they can lower its efficacy. Also, avoid ketoconazole, which may increase side effects. Discuss all medications you are currently taking with your healthcare provider to prevent harmful interactions.

• Contraindications: Do not use Cresemba if you are taking ritonavir (Norvir) 400 mg every 12 hours, strong CYP3A4 inhibitors (e.g., ketoconazole), rifampin, carbamazepine (Tegretol), long-acting barbiturates, or St. John's Wort. Additionally, those with a history of short QT syndrome should avoid this medication. Always consult your healthcare provider if any of these conditions apply to you before starting treatment with Cresemba.

When taking this medication, some individuals may experience common side effects such as dizziness, nausea, vomiting, diarrhea, headache, constipation, cough, and trouble sleeping. These are typically mild and temporary, but if they persist or worsen, it's important to consult your healthcare provider. Additionally, some may notice low potassium levels, stomach pain, elevated liver enzymes, or fatigue, which are also common but should be monitored.

More serious side effects, though less common, require prompt medical attention. These include muscle cramps, weakness, irregular heartbeat, significant swelling of the limbs, back pain, and mental changes like confusion or anxiety. In rare cases, severe side effects like a fast or irregular heartbeat, chest pain, fainting, signs of kidney problems, or seizures may occur, necessitating immediate medical help.

There is a rare risk of serious liver disease with this medication. Symptoms like persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the skin or eyes, and dark urine should not be ignored and require urgent medical evaluation. Be aware of any rash, as it could indicate a severe reaction, and seek advice if a rash develops. While a very serious allergic reaction is uncommon, symptoms such as rash, severe dizziness, or trouble breathing warrant immediate medical care.

Always report new or concerning side effects to your healthcare provider to ensure timely and appropriate management. This list may not cover all possible side effects, so staying informed and vigilant is key to managing your health while on this medication.