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The safety information and warnings provided here are essential for anyone using voriconazole (Vfend). Review these details thoroughly and discuss any concerns with your healthcare provider.

• Liver Damage: Although rare, voriconazole (Vfend) use can lead to liver issues. It is advisable to undergo liver function tests before and during treatment. Avoid alcohol, as it can exacerbate liver problems. Seek immediate medical help if you experience yellowing of the skin or eyes, changes in stool color, dark urine, abdominal swelling, stomach pain, or confusion. Discontinuation of the drug may be necessary to prevent further liver damage. Be cautious if you have liver problems, certain blood cancers, or are taking other liver-affecting medications.

• Abnormal Heart Rhythm: Voriconazole (Vfend) may cause serious heart rhythm disturbances, such as QT prolongation. This risk increases with factors like electrolyte imbalances, existing heart rhythm issues, or concurrent use of other QT-prolonging medications like amiodarone or ciprofloxacin. Regular heart monitoring through ECGs is recommended. Contact emergency services if you experience palpitations, breathing difficulties, chest pain, or lightheadedness. Risks are higher for those with low potassium or magnesium, older age, kidney issues, or a history of heart problems.

• Vision Changes: Potential side effects include blurred vision, eyesight alterations, and light sensitivity, especially if treatment exceeds 28 days. An eye exam is advised in such cases or if significant vision changes occur. Avoid night driving and use sunglasses in bright conditions. Contact your prescriber if vision issues interfere with daily activities.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, are possible during IV infusion. Seek immediate medical attention if you have breathing difficulties, swelling, or a rapid heartbeat.

• Severe Skin Reactions: Rare conditions like Stevens-Johnson syndrome, toxic epidermal necrolysis, or DRESS may occur. Look out for skin rash, blisters, or peeling, along with fever and swollen lymph nodes, and seek medical help immediately.

• Sun and Light Sensitivity: This medication can increase sunburn risk. Use high-SPF sunscreen and protective clothing outdoors, even in winter or on cloudy days.

• Pregnancy Risks: Avoid voriconazole (Vfend) during pregnancy due to potential developmental harm to the fetus. Use birth control and inform your prescriber if you are pregnant or planning pregnancy.

• Low Adrenal Hormone Levels: Some patients report symptoms like fatigue, dizziness, and nausea indicative of low adrenal hormones. Notify your prescriber if these symptoms occur.

• Pancreatitis: Inflammation of the pancreas has been reported. Symptoms include stomach pain, nausea, vomiting, and jaundice. Inform your healthcare provider if these symptoms appear, especially after recent chemotherapy or stem cell transplant.

• Bone and Teeth Problems: Long-term use can lead to bone pain or tooth discoloration. Report these symptoms to your prescriber for further evaluation.

• Kidney Problems: Kidney issues have been reported, though the cause is unclear. Regular kidney function tests may be necessary.

Contraindications: Avoid voriconazole (Vfend) if taking medications such as pimozide, quinidine, ivabradine, sirolimus, rifampin, carbamazepine, long-acting barbiturates, St. John's Wort, rifabutin, ergot alkaloids, naloxegol, tolvaptan, or lurasidone. Additionally, avoid if taking efavirenz at 400 mg or more, ritonavir at 400 mg, or during venetoclax initiation for CLL or SLL due to tumor lysis syndrome risk. Always consult your healthcare provider if these apply to you.

When taking this medication, some individuals may experience mild side effects such as nausea, vomiting, headaches, and rash. While these effects are typically not serious, it is advisable to consult a healthcare provider if they persist or worsen. Vision changes and fever have also been reported, occurring in some users.

In rare instances, more severe side effects can occur, requiring immediate medical attention. These include fast or irregular heartbeat, severe dizziness, fainting, hallucinations, and signs of liver disease such as persistent nausea, loss of appetite, abdominal pain, yellowing of the skin or eyes, and dark urine. Other potential symptoms of concern include significant changes in vision, eye sensitivity to light, eye pain, and signs of kidney problems.

Additionally, some users may experience low blood potassium levels, high blood pressure, low platelet count, or increased liver enzymes. These symptoms, along with any unusual bruising, bleeding, or severe allergic reactions such as persistent fever, new or worsening lymph node swelling, severe dizziness, or trouble breathing, should prompt urgent medical help. Always remain vigilant for any unusual symptoms or changes in your health while on this medication.

Voriconazole may influence how other medications are processed in your body, potentially altering their effectiveness. This includes drugs such as eletriptan, ergot alkaloids like dihydroergotamine and ergotamine, specific medications for irregular heartbeat such as disopyramide, dronedarone, and quinidine, as well as ivabradine, lurasidone, naloxegol, pimozide, ranolazine, sirolimus, certain "statin" cholesterol medications like lovastatin and simvastatin, and tolvaptan, among others.

Conversely, certain medications can impact how voriconazole is metabolized, which might affect its efficacy. Examples include butalbital, efavirenz, mitotane, rifamycins such as rifabutin and rifampin, ritonavir, secobarbital, and some seizure medications like carbamazepine and phenobarbital, along with St. John's wort.

It is important to note that voriconazole, like many other medications, can affect heart rhythm (QT prolongation). Therefore, inform your healthcare provider about all the medications and supplements you are taking, including prescription, over-the-counter drugs, and herbal products, as this list may not include all possible interactions. Your doctor might need to adjust your treatment plan to ensure safety and effectiveness.