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When taking this medication, you might experience common side effects such as drowsiness, dizziness, fatigue, dry mouth, nausea, headache, or difficulty sleeping. These symptoms are usually mild and may improve as your body adjusts to the medication. However, if they persist or worsen, consult your healthcare provider.

In rare cases, serious side effects can occur. Be alert for symptoms like difficulty urinating, rapid or irregular heartbeat, tremors, changes in mood or mental state (such as anxiety or confusion), or unusual weakness. If you experience any of these, seek medical attention immediately.

Severe side effects are very rare but require urgent medical care. These include seizures, which are a medical emergency. Additionally, although uncommon, serious allergic reactions can happen. Look out for rash, itching, swelling of the face, tongue, or throat, severe dizziness, and trouble breathing. If these symptoms arise, get emergency help right away.

This overview does not cover all possible side effects. If you notice any other unusual symptoms, contact your healthcare provider for guidance.

Avoid taking MAO inhibitors, such as isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine, with this medication due to the risk of a serious, potentially life-threatening interaction. It's important not to take most MAO inhibitors for at least two weeks before starting this treatment. Consult your doctor about when to begin or stop this medication.

Inform your doctor or pharmacist if you're using products that cause drowsiness, including opioid pain or cough relievers like codeine and hydrocodone, alcohol, marijuana (cannabis), sleep or anxiety medications such as alprazolam, lorazepam, or zolpidem, muscle relaxants like carisoprodol or cyclobenzaprine, or other antihistamines like chlorpheniramine or diphenhydramine.

Check the labels on all your medicines, including those for allergies or cold and cough, as they might contain ingredients causing drowsiness or similar components like decongestants such as phenylephrine. Consult your pharmacist for safe use of these products.

Do not use other skin-applied antihistamines, such as diphenhydramine cream, ointment, or spray, while on this medication to avoid increased side effects.

Avoid using cetirizine together with similar drugs like hydroxyzine and levocetirizine. This medication may affect certain lab tests, such as allergy skin tests, potentially leading to incorrect results. Ensure that lab staff and all your healthcare providers are aware of your medication use.