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The following safety information outlines important risks and precautions associated with hyoscyamine use. Please read these carefully and consult your healthcare provider if you have any questions or concerns.

• Dizziness and Drowsiness: Hyoscyamine may cause sleepiness, dizziness, and blurred vision. Avoid driving or engaging in activities that require full attention until you understand how the medication affects you.

• Mood and Behavioral Changes: This medication can impact your mood, thoughts, or cognitive abilities, leading to confusion, memory loss, or disorientation. Agitation, hallucinations, and euphoria are also possible. In severe cases, it may result in a coma. These symptoms usually subside within 12 to 48 hours after discontinuing use. It is crucial to inform your healthcare provider immediately if you notice any changes in mood or behavior. Higher risk exists for individuals aged 65 or older and those with mental health conditions.

• Elevated Heart Rate: If you have heart issues, including heart failure, previous heart attacks, or high blood pressure, notify your healthcare provider. Hyoscyamine can increase your heart rate, potentially aggravating certain heart conditions. Seek medical advice if you experience a racing or pounding heart.

• Autonomic Function Changes: Hyoscyamine can alter involuntary bodily functions, such as slowing gut muscles, which may cause constipation. It can also reduce saliva and sweat production, resulting in dry mouth and increased thirst, heightening the risk of heat stroke. Other effects may include changes in heartbeat or vision. Consult your provider if you notice any alterations in these functions. Do not take hyoscyamine if you have a fever without prior medical advice. Individuals aged 65 or older may be at greater risk.

• Urinary Difficulties: Use caution if you have prostate problems, as hyoscyamine may worsen these conditions and lead to urination difficulties.

• Gut Issues: If you have had procedures like a colostomy, inform your provider before using hyoscyamine for diarrhea, as it may exacerbate blockages in the gut.

Contraindications highlight situations where hyoscyamine should not be used due to potential severe health risks. Consult your healthcare provider if any of the following apply to you:

• Glaucoma
• Urinary tract obstruction
• Stomach or intestinal blockage
• Chronic constipation
• Unstable heart or bleeding disorders
• Severe ulcerative colitis with toxic megacolon
• Myasthenia gravis

In case of an overdose, seek emergency medical attention immediately.

When taking this medication, some common side effects may occur, including dizziness, drowsiness, blurred vision, dry mouth, headache, trouble sleeping, constipation, flushing, dry skin, and decreased sweating. These are generally mild and should not cause alarm, but if they persist or worsen, it's advisable to consult a healthcare provider. To manage dry mouth, consider using sugarless gum, hard candy, or a saliva substitute, and stay hydrated.

In some cases, individuals may experience additional side effects such as trouble urinating, dry eyes, or heat intolerance. While these can be uncomfortable, they are not typically serious. However, if you notice symptoms like a fast or irregular heartbeat, confusion, or short-term memory loss, it's important to inform your healthcare provider.

Serious side effects are rare but require immediate attention. These include significant mood or behavioral changes, such as confusion, agitation, or hallucinations, and symptoms of an irregular heartbeat, like fainting or chest pain. Additionally, any signs of a severe allergic reaction, such as a rash, swelling, or difficulty breathing, should prompt urgent medical assistance. Always stay vigilant for any unusual symptoms and seek medical advice when necessary.

It's crucial to inform your doctor and pharmacist about all medications and supplements you're taking before using this drug, as it may interact with several others. Be particularly cautious if you are using azole antifungal drugs like ketoconazole and itraconazole, or bisphosphonates such as alendronate and risedronate. Corticosteroids, including prednisone, slow-dissolving digoxin tablets, potassium supplements, and pramlintide can also interact with this medication.

Additionally, if you're taking medications that cause drowsiness, such as opioid pain relievers like codeine and hydrocodone, alcohol, marijuana, or drugs for sleep and anxiety like alprazolam, lorazepam, and zolpidem, these may have increased effects. Muscle relaxants, such as carisoprodol and cyclobenzaprine, and antihistamines like cetirizine and diphenhydramine, can also lead to enhanced drowsiness. Always check the labels of all your medications, including over-the-counter allergy or cold products, as they may contain ingredients that could increase drowsiness. Consult your pharmacist for advice on using these products safely.

This medication may also interfere with certain laboratory tests, potentially leading to false results. Therefore, it's important to inform lab personnel and all healthcare providers that you are using this drug.