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The following safety information outlines important considerations for the use of hydrocortisone (Anusol-HC). Please ensure you understand these warnings and consult your healthcare provider for any concerns or questions.

• Hormonal Effects and Withdrawal: Prolonged use of hydrocortisone (Anusol-HC) rectally can lead to adrenal suppression, a condition where your body ceases the production of its own steroid hormones. This risk is increased with extended use, excessive dosage, or covering the application area with a bandage. Young children are particularly susceptible. Stopping the medication suddenly may cause withdrawal symptoms such as dizziness, low energy, and nausea. It's crucial to discuss any plans to discontinue use with your healthcare provider.

• Infection Risks: Long-term use of hydrocortisone (Anusol-HC) can elevate the risk of developing fungal or bacterial infections. If you have a current skin infection, using this medication could exacerbate the condition. Symptoms such as redness, swelling, pain, pus, or lack of symptom improvement within seven days should be promptly reported to your healthcare provider.

• Skin Reactions: Excessive or improper use of hydrocortisone (Anusol-HC) can result in various skin issues, including thinning, stretch marks, spider veins, burning, itching, irritation, dryness, inflamed hair follicles, changes in skin color, or rash. It is important to follow your provider's directions and report any new or worsening skin problems immediately.

Remember, these precautions are essential for safe usage of hydrocortisone (Anusol-HC). Always consult with your healthcare provider for personalized advice and before making any changes to your treatment plan.

When using this medication, some individuals may experience common side effects such as burning, itching, skin irritation, or dry skin. These effects are typically mild and often resolve on their own. However, if they persist or become bothersome, it's important to consult with your healthcare provider for guidance.

In addition to the common side effects, there are other possible reactions that can occur. These include inflamed hair follicles, acne-like bumps, changes in skin color, rash, heat rash, thinning skin, stretch marks, pruning or wrinkling of the skin, and unexpected hair growth. While these side effects may not be as common, they should be monitored, and medical advice should be sought if they arise.

There are also rare but serious side effects associated with the medication. These include symptoms of a serious infection such as persistent sore throat or fever, rectal bleeding, noticeable changes in the skin's appearance, or signs of an allergic reaction like rash, severe dizziness, or trouble breathing. Additionally, in rare cases, the medication might be absorbed into the bloodstream, potentially causing symptoms such as unusual tiredness, weight loss, headache, swelling of the ankles or feet, increased thirst or urination, and vision problems. Withdrawal symptoms like long-term fatigue, muscle weakness, poor appetite, weight loss, and belly pain may also occur. Immediate medical attention is necessary if any of these serious side effects develop.