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Hydrocortisone (Anusol-HC) is a medication that requires careful usage to avoid potential risks and side effects. Below are important safety warnings and precautions associated with its use. Please consult your healthcare provider with any questions or concerns.

• Hormonal Issues and Withdrawal Symptoms: Prolonged use of hydrocortisone (Anusol-HC) rectally can lead to adrenal suppression, where the body reduces its own steroid hormone production. Abruptly stopping the medication may result in withdrawal symptoms like dizziness, fatigue, and nausea. To avoid these issues, follow your provider's advice, which may include a rectal exam to determine suitability. Always consult your provider before discontinuing use. Risk factors include extended usage, excessive dosage, bandaging the treated area, and use in young children.

• Increased Risk of Skin Infections: Long-term use of hydrocortisone (Anusol-HC) can increase the likelihood of developing fungal or bacterial skin infections. Avoid using this medication if you have an existing skin infection, as it may exacerbate the condition. If you experience symptoms such as redness, swelling, pain, pus, or lack of improvement after 7 days of treatment, inform your healthcare provider, as these could indicate a new infection.

• Skin Irritation and Damage: Overuse or misuse of hydrocortisone (Anusol-HC) can cause skin irritation, including thinning, stretch marks, spider veins, burning, itching, dry skin, inflamed hair follicles, changes in skin color, or rashes. A rectal exam may be recommended by your provider to ensure appropriate use. Report any new or worsening skin issues to your provider promptly. Risks are associated with excessive or inappropriate application of the medication.

Be sure to adhere to your healthcare provider's instructions when using hydrocortisone (Anusol-HC) to mitigate these risks and ensure safe treatment.

When using this medication, you may experience some common side effects such as burning, itching, dryness, and skin irritation. These effects are generally mild and should not cause alarm, but if they persist or worsen, consider reaching out to your healthcare provider. Additionally, you might notice changes in skin color, inflamed hair follicles, or acne-like bumps. Some users report thinning skin, stretch marks, or pruning and wrinkling of the skin, which can be concerning but are typically manageable with guidance from a healthcare professional.

There are more severe side effects that, while rare, require immediate medical attention. These include new or persistent rectal bleeding, unusual bruising or bleeding, symptoms of stomach or intestinal bleeding like black stools or vomit that resembles coffee grounds, and significant mood or mental changes such as depression or agitation. Other serious symptoms to be aware of include bone pain, irregular heartbeat, signs of infection like a persistent sore throat or fever, muscle weakness, and an unusual level of tiredness or weight loss.

In more exceptional cases, this medication may lead to systemic absorption, causing side effects associated with excessive corticosteroid levels, particularly in children or those using the medication long-term. Symptoms can include extreme fatigue, swelling of the ankles or feet, increased thirst or urination, and vision problems. A severe allergic reaction is very rare, but if you experience symptoms such as rash, itching or swelling of the face, severe dizziness, or difficulty breathing, seek emergency medical help immediately. Always keep in communication with your healthcare provider about any side effects you experience.