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Benzhydrocodone/acetaminophen, also known as Apadaz, carries several important safety warnings and precautions due to its potential risks. Please review the following information carefully and discuss any concerns with your healthcare provider.

• Risk of Abuse and Addiction: This medication can lead to addiction, misuse, or abuse, potentially resulting in overdose and death. It should only be used as prescribed and at the smallest effective dose for the shortest duration. Individuals with a history of substance abuse or mental health conditions are at higher risk.

• Respiratory Depression: Apadaz can cause life-threatening breathing problems, especially when starting the medication or increasing the dose. This risk is heightened when combined with alcohol or other drugs that cause drowsiness or slowed breathing. Older adults and those with pre-existing lung conditions should exercise caution.

• Liver Damage: Acetaminophen, a component of Apadaz, can cause severe liver damage if taken in excess (more than 4000 mg daily) or combined with alcohol. It is crucial to monitor all medications to avoid exceeding safe acetaminophen levels.

• Pregnancy and Newborn Risks: Long-term use during pregnancy can lead to neonatal opioid withdrawal syndrome, a potentially life-threatening condition for newborns. This medication should only be used during pregnancy if absolutely necessary and at the lowest effective dose.

• Drug Interactions: Certain medications can affect how Apadaz works in the body, potentially leading to increased side effects or withdrawal symptoms. Avoid combining this medication with alcohol, muscle relaxants, sedatives, or other drugs that depress the central nervous system.

• Extreme Drowsiness: Apadaz can cause significant drowsiness and impair cognitive functions. Avoid activities requiring alertness, such as driving, until you know how the medication affects you. Alcohol and other sedative medications can exacerbate these effects.

• Hormonal and Blood Pressure Effects: Long-term use may lead to hormonal imbalances and low blood pressure. Symptoms like dizziness, tiredness, and low blood pressure should be reported to a healthcare provider.

• Severe Skin Reactions: Rare but serious skin reactions can occur. Discontinue use and seek emergency medical attention if symptoms such as rash or blistering develop.

• Seizure Risk: Individuals with a history of seizures should be aware that Apadaz may increase seizure frequency.

• Physical Dependence and Withdrawal: Regular use can lead to physical dependence. Do not stop taking this medication abruptly without consulting your healthcare provider to avoid withdrawal symptoms.

In case of an overdose, seek immediate medical help. Signs of overdose include extreme drowsiness, slow breathing, or loss of consciousness. If anyone accidentally ingests this medication, especially children, urgent medical attention is required.

This medication should not be used if you have severe breathing issues, an asthma attack, or known gut blockages. Always consult with your healthcare provider before starting or stopping Apadaz to ensure it is safe for your specific health conditions.

When taking this medication, you may experience some common side effects, including nausea, sleepiness, vomiting, constipation, itching, dizziness, and headache. These effects are generally mild and tend to diminish as your body adjusts to the medication. To alleviate constipation, increase your intake of dietary fiber, stay hydrated, and engage in regular physical activity. If dizziness or lightheadedness occurs, rise slowly from sitting or lying positions.

In addition to these common side effects, some individuals may also encounter stomach pain, gas, low energy, tremors, shortness of breath, low blood pressure, or a feeling of warmth. While these are typically manageable, it is important to consult your healthcare provider if they persist or worsen over time.

There are also serious side effects that, although rare, require immediate medical attention. These include slowed breathing, symptoms of overdose (such as extreme sleepiness, slow heartbeat, and cold or clammy skin), signs of liver damage (like dark urine or yellowing skin), and withdrawal symptoms (including anxiety and restlessness). Additionally, a severe allergic reaction may occur, characterized by difficulty breathing, swelling of the face, tongue, or throat, and skin changes like blisters or rash. If any of these serious symptoms develop, seek urgent medical care right away.

Certain medications can interact with this drug, potentially causing serious side effects such as slow or shallow breathing, and severe drowsiness or dizziness. Notably, pain medications like mixed opioid agonist/antagonists (e.g., Butorphanol, Nalbuphine, pentazocine), as well as Naltrexone and samidorphan, can interact with it. If you are using other substances that cause drowsiness or breathing issues, such as other opioid painkillers (e.g., codeine, hydrocodone, Oxycodone), alcohol, marijuana, sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or antihistamines (e.g., Cetirizine, diphenhydramine), make sure to inform your doctor or pharmacist.

It's important to check the labels of all your medications, including allergy or cold remedies, as they may contain ingredients that induce drowsiness. Consult your pharmacist for safe usage of these products.

Additionally, some medications can affect how your body processes benzhydrocodone/acetaminophen, which may alter its effectiveness. This includes azole antifungals (like Ketoconazole), levoketoconazole, macrolide antibiotics (like Erythromycin), Mifepristone, some HIV medications (like tipranavir), rifamycins (such as Rifabutin, Rifampin), Ritonavir, and certain seizure medications (like Carbamazepine, Phenytoin).

Lastly, this drug may interfere with certain laboratory tests, potentially causing inaccurate results. Ensure that your lab technicians and all healthcare providers are aware that you are taking this medication.