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Experiencing nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness is common with this medication. These side effects may lessen as your body adjusts to the treatment. If they persist or become bothersome, consult your healthcare provider. To manage constipation, incorporate dietary fiber, stay hydrated, and maintain regular physical activity. A laxative might be necessary, so ask your pharmacist for a recommendation. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions.

While serious side effects are less common, they require immediate attention. Contact your healthcare provider if you experience sleep apnea, significant mood changes, severe stomach pain, difficulty urinating, or symptoms indicating adrenal gland issues, such as loss of appetite, unusual fatigue, or weight loss.

In rare instances, severe side effects like fainting, seizures, and shallow breathing can occur, necessitating urgent medical care. Similarly, a serious allergic reaction is rare, but requires immediate help if symptoms like rash, swelling, severe dizziness, or breathing difficulties arise. If you notice any other unusual effects, reach out to your healthcare provider for guidance.

Please refer to the Warning and How to Use sections for more information. This medication may interact with certain other drugs, including specific pain medications like mixed opioid agonist/antagonists (such as Butorphanol, Nalbuphine, and pentazocine), as well as Naltrexone and samidorphan. Combining this medication with other substances that cause drowsiness or breathing issues can increase the risk of serious side effects, such as slow or shallow breathing and severe drowsiness or dizziness. Inform your doctor or pharmacist if you are using other opioid pain or cough medications (like codeine or hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (like Alprazolam, Lorazepam, or Zolpidem), muscle relaxants (like Carisoprodol or Cyclobenzaprine), or antihistamines (such as Cetirizine or diphenhydramine).

Be sure to check the labels on all your medications, including those for allergies or cough-and-cold, as they may contain ingredients that cause drowsiness. Consult your pharmacist on how to use these products safely. Certain medications can affect how oxycodone/acetaminophen is processed in your body, impacting its effectiveness. These include azole antifungals (like Ketoconazole), macrolide antibiotics (such as Erythromycin), levoketoconazole, Mifepristone, HIV medications (such as tipranavir), rifamycins (such as Rifabutin and Rifampin), Ritonavir, and certain seizure medications (like Carbamazepine and Phenytoin), among others. Additionally, this medication may interfere with certain laboratory tests, such as amylase or lipase levels, potentially causing inaccurate test results. Ensure all your healthcare providers and lab personnel are aware of your medication use.