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Oxycodone/acetaminophen is a medication that carries significant risks, including addiction, overdose, and potentially fatal breathing problems. It is crucial to use this medication as prescribed, taking the smallest effective dose for the shortest duration necessary. Below are key safety and warning instructions to help ensure safe use:

• Risk of Addiction and Misuse: This medication can be addictive, and misuse can result in severe side effects, including overdose and death. It is vital to follow your healthcare provider's prescription closely and not alter the dosage without consulting them. Individuals with a personal or family history of substance use disorders or mental health issues may be at higher risk.

• Breathing Problems: Starting this medication or increasing the dose can lead to dangerously slow breathing. Avoid combining this drug with alcohol or other medications that cause drowsiness. Your doctor may recommend naloxone to counteract opioid-induced breathing issues; ensure you and your household know how to use it. Seek immediate medical help if experiencing breathing difficulties.

• Liver Damage: Acetaminophen, a component of this medication, can cause severe liver damage if taken in excess. Adults should not exceed 4 grams per day. Individuals with liver problems or those who consume alcohol regularly should be particularly cautious. Always check other medications for acetaminophen content and consult your provider if unsure.

• Interactions with Other Substances: Certain drugs, such as erythromycin, ketoconazole, and ritonavir, may interact with oxycodone/acetaminophen, increasing the risk of side effects. Discuss all medications you are taking with your healthcare provider to avoid harmful interactions.

• Pregnancy and Newborns: Women of childbearing age should discuss potential risks with their doctor. Use during pregnancy should be limited to essential cases, as it may slightly increase birth defect risks and can cause withdrawal symptoms in newborns if used long-term. Notify your healthcare provider if you notice withdrawal symptoms in your baby.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, can occur. Discontinue use and seek immediate medical attention if you experience symptoms such as swelling, rash, or difficulty breathing.

• Physical Dependence and Withdrawal: Long-term use may lead to physical dependence. Do not abruptly stop the medication; consult your healthcare provider for a gradual dose reduction plan to avoid withdrawal symptoms.

• Emergency Situations: In case of overdose, symptoms include nausea, vomiting, extreme drowsiness, slow heartbeat, and cold skin. Carry naloxone if prescribed and call 911 immediately if an overdose is suspected. Keep medications out of reach of children, pets, and visitors to prevent accidental ingestion or misuse.

It is imperative to maintain open communication with your healthcare provider regarding your use of oxycodone/acetaminophen and any concerns you may have. Following these guidelines diligently will help mitigate the risks associated with this medication.

When taking this medication, you might experience some common side effects like nausea, vomiting, constipation, dizziness, lightheadedness, and drowsiness. These effects are generally mild and may lessen as your body adjusts to the medication. To manage constipation, consider increasing your intake of dietary fiber, staying hydrated, and exercising regularly. If dizziness occurs, try to rise slowly from sitting or lying positions.

Some users might also encounter headaches, sweating, heartburn, bloating, itching, changes in taste, stomach pain, muscle pain, and fluctuations in blood pressure or heartbeat. While these are not uncommon, consult your healthcare provider if they persist or worsen.

There are serious side effects that, although rare, demand immediate medical attention. These include severely slow breathing, signs of an overdose such as extreme drowsiness or unresponsiveness, and symptoms like bluish lips or fingertips. Additionally, watch for signs of opioid withdrawal, such as anxiety and irritability, as well as severe allergic reactions, which might present as rashes, hives, or difficulty breathing.

Remember that a serious reaction, though rare, requires prompt medical care. If you notice any other effects, even if not listed here, reach out to your healthcare provider for guidance.

When taking Percocet (oxycodone/acetaminophen), it's important to be aware of potential interactions with other drugs. Some medications, like nalmefene, Naltrexone, and safinamide, should not be combined with Percocet. Your doctor may choose alternative treatments if you're using any of these.

Other medications that typically should not be used with Percocet include certain pain medications (like Butorphanol, Nalbuphine, pentazocine), and samidorphan. These combinations can increase the risk of serious side effects, such as severe drowsiness, dizziness, or slow breathing. If both medications are necessary, your doctor might adjust dosages or how often you use them.

Percocet can also interact with drugs that may cause drowsiness or breathing issues, including opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (like Alprazolam, Lorazepam, Zolpidem), muscle relaxants (such as Carisoprodol, Cyclobenzaprine), and some antihistamines (such as Cetirizine, diphenhydramine). Always review your medications' labels for ingredients that might cause drowsiness and consult your pharmacist on safe usage.

Further, some medications can influence how Percocet is processed in your body, potentially altering its effectiveness. These include azole antifungals (e.g., Ketoconazole), macrolide antibiotics (e.g., Erythromycin), HIV medications (e.g., tipranavir), rifamycins (e.g., Rifabutin, Rifampin), Ritonavir, and certain seizure treatments (such as Carbamazepine, Phenytoin).

Lastly, Percocet may interfere with specific lab tests, such as those measuring amylase or lipase levels, potentially leading to inaccurate results. It is important to inform all healthcare providers and lab staff that you are taking this medication.