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The following information highlights crucial safety warnings and precautions for the use of Trezix. Carefully consider these details and consult your healthcare provider with any concerns.

• Addiction, Abuse, and Misuse: Trezix poses a risk of addiction, abuse, and misuse, even when taken as prescribed. Misuse or excessive use can lead to overdose and potentially fatal consequences. To minimize this risk, your healthcare provider will prescribe the minimum effective dose for the shortest duration. Increased risk for individuals with a personal or family history of substance abuse and those with mental health conditions.

• Respiratory Depression: Trezix may cause dangerously slowed or irregular breathing. This risk is heightened at the start of treatment or after a dose increase and can occur even at prescribed doses. Immediate medical attention is necessary if symptoms such as shortness of breath or bluish extremities appear. Higher risk for individuals over 65, those with COPD, or taking sedatives.

• Overdose: Overdose can occur from taking Trezix as prescribed, incorrect dose conversion from another opioid, or accidental ingestion by others. Overdose symptoms necessitate urgent treatment to prevent fatal outcomes. Increased risk for those with a history of opioid use disorder, concurrent use of sedatives, or alcohol consumption.

• Child Safety: Trezix is particularly dangerous for children, who are more susceptible to life-threatening respiratory depression and overdose. It should not be given to children under 12 or those under 18 who have recently had tonsil or adenoid surgery. Keep this medication out of reach of children and seek emergency help if accidental ingestion occurs.

• Liver Damage: Trezix contains acetaminophen, and exceeding the daily limit of 3 to 4 grams can cause liver harm. Consult your healthcare provider for your daily acetaminophen limit, especially if you have a history of liver issues or consume alcohol.

• Drug Interactions: Certain medications can alter the effectiveness and safety of Trezix. Discuss all medications you are taking with your healthcare provider to avoid adverse interactions.

• Pregnancy and Newborn Risk: Opioids can harm an unborn baby, leading to neonatal opioid withdrawal syndrome, which is potentially life-threatening. Inform your healthcare provider if you have used Trezix during pregnancy.

• Breastfeeding: Dihydrocodeine in Trezix can transfer to breast milk, posing a risk of severe respiratory issues and death in infants. Alternative pain relief options should be considered for breastfeeding individuals.

• Concentration and Sleepiness: Trezix may cause significant drowsiness and impair concentration. Avoid alcohol and other sedatives, and assess your response to the medication before engaging in tasks requiring alertness.

• Dependence and Withdrawal: Long-term use can lead to physical dependence and withdrawal symptoms if stopped abruptly. Consult your provider before making any changes to your dosage.

• Serotonin Syndrome: Combining Trezix with drugs that increase serotonin can cause serotonin syndrome, a serious condition. If symptoms such as hallucinations or high fever occur, seek immediate medical care.

• Hormonal Effects: Chronic use of opioids can lead to decreased hormone levels, manifesting as nausea, fatigue, or dizziness. Report these symptoms to your healthcare provider.

• Seizures: Trezix may increase seizure frequency in susceptible individuals. Inform your provider if you experience seizures while on this medication.

Contraindications: Do not use Trezix if you are:

• Under 12 years of age
• Under 18 years with recent tonsil or adenoid surgery
• Experiencing severe respiratory depression
• Suffering from severe asthma
• Having a stomach blockage

Always discuss your medical history and any concerns with your healthcare provider to ensure the safe use of Trezix.

When taking this medication, it's important to be aware of potential side effects. Common side effects, which are usually mild, include lightheadedness, sleepiness, headache, fatigue, nausea, vomiting, diarrhea, and constipation. Some individuals may also experience stomach pain, itchiness, skin irritation, or changes in mood such as anxiety, excitement, or irritability. Other symptoms can include trouble sleeping, restlessness, feeling tense, tremors, sweating, a racing heart, increased urination, ringing in the ears, and visual disturbances like blind spots.

There are other side effects that might occur, such as slowed breathing, confusion, small pupils, and difficulty urinating. Kidney issues, dry mouth, indigestion, loss of appetite, hallucinations, vivid dreams, abnormal blood cell counts, erectile dysfunction, or loss of menstrual periods have also been reported. If these effects occur, particularly if they are severe, contacting a healthcare provider is advised.

Serious side effects, while rare, require immediate medical attention. If you experience extremely slowed breathing, overdose symptoms, or withdrawal signs such as suicidal thoughts or extreme anxiety, seek help urgently. Severe liver damage may present as stomach pain, dark urine, or yellowing skin and eyes. Serious skin reactions could involve painful rashes or blisters. Additionally, serotonin syndrome, characterized by hallucinations, seizures, or extreme confusion, and seizures themselves, necessitate prompt medical care.