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Pimozide

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Pimozide is an oral antipsychotic medication specifically used to manage symptoms of Tourette syndrome when other treatments have failed. It is effective in reducing involuntary movements (motor tics) and vocal outbursts (vocal tics) by lowering the levels of dopamine, a natural substance in the brain. This reduction in dopamine activity helps alleviate the severity of tics. Pimozide is particularly recommended for severe cases where symptoms significantly impact daily life. It is important to note that Pimozide should not be used for mild symptoms. Adults typically take multiple doses throughout the day, while children 12 years and older are usually prescribed a single dose at bedtime. Common side effects may include sleepiness, drowsiness, and difficulty with muscle movement. Although the brand name Orap is not available, the generic form of the medication is accessible. Always consult with a healthcare professional for personalized medical advice and before starting any new medication.
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1MG, Pimozide (30 Tablets)

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CVS

$42.60

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Walgreens

$21.17

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Walmart

$28.49

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Rite Aid

$54.42

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$55.61

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$42.60

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Pimozide dosage forms

The average cost for 30 Tablets of Pimozide at 2MG is $44.31 with a free coupon. This is 32.00% off the average retail price of $138.46
DosageQuantityPrice fromPer unit
2MG30 Tablets$44.31$1.48
1MG30 Tablets$28.49$0.95

Pimozide Warnings

The following safety information outlines the potential risks and necessary precautions when using this medication. Please read carefully and discuss any concerns with your healthcare provider.

  • Movement Disorders: Use of antipsychotic medications like pimozide can lead to a movement disorder known as tardive dyskinesia, characterized by symptoms such as lip smacking, eye blinking, tongue protrusion, and grimacing. The risk increases with long-term use or high doses and may become permanent. Report any symptoms to your healthcare provider, as they may diminish upon discontinuation of the medication.

  • Neuroleptic Malignant Syndrome: This rare but serious condition is associated with antipsychotic medications and presents with high fever, rapid heartbeat, muscle rigidity, and confusion. Immediate medical attention is necessary if these symptoms occur, and your healthcare provider may need to prescribe an alternative medication.

  • Increased Infection Risk: Pimozide can decrease white blood cell counts, compromising the body’s ability to fight infections. Regular blood tests will monitor these levels, and the medication may need to be discontinued if they become too low. Notify your healthcare provider if you experience persistent fever or sore throat.

  • Heart Rhythm Alterations: Pimozide may cause changes in heart rhythm, observable in ECG scans, especially in individuals treated for Tourette syndrome. Regular heart monitoring is advisable, especially if taking high doses, other heart-affecting medications, or if you have low potassium levels.

Contraindications: Do not use this medication if you have:

  • Tics unrelated to Tourette syndrome
  • Tics caused by other medications
  • Irregular heartbeats
  • Comatose states of any origin
  • Concurrent use of citalopram, escitalopram, sertraline, macrolide antibiotics, or other drugs that significantly inhibit pimozide breakdown

Consult your healthcare provider if any of these conditions apply to you to avoid serious health risks.

Pimozide Side Effects

Common side effects:

  • drowsiness
  • dizziness
  • lightheadedness
  • dry mouth
  • blurred vision
  • tiredness
  • weakness

Less common but important to monitor:

  • muscle stiffness
  • shaking
  • restlessness
  • drooling
  • difficulty swallowing
  • shuffling walk
  • tardive dyskinesia

Serious side effects:

  • severe dizziness
  • fainting
  • slow heartbeat
  • seizures
  • signs of infection (persistent sore throat or fever)
  • increased prolactin levels
  • neuroleptic malignant syndrome
  • allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)

Pimozide Interactions

Interactions with high risk of serious adverse effects and should be avoided:

  • Alfuzosin
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amprenavir
  • Anagrelide
  • Aprepitant
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azithromycin
  • Bedaquiline
  • Bepridil
  • Boceprevir
  • Buprenorphine
  • Buserelin
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clomipramine
  • Clozapine
  • Cobicistat
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Darunavir
  • Degarelix
  • Delamanid
  • Delavirdine
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dirithromycin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Dronedarone
  • Droperidol
  • Ebastine
  • Efavirenz
  • Encorafenib
  • Entrectinib
  • Eribulin
  • Erythromycin
  • Escitalopram
  • Famotidine
  • Felbamate
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluvoxamine
  • Formoterol
  • Fosamprenavir
  • Fosaprepitant
  • Foscarnet
  • Fosphenytoin
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imipramine
  • Indinavir
  • Inotuzumab Ozogamicin
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Lefamulin
  • Lenvatinib
  • Letermovir
  • Leuprolide
  • Levofloxacin
  • Lofexidine
  • Lumefantrine
  • Macimorelin
  • Mefloquine
  • Mesoridazine
  • Methadone
  • Metoclopramide
  • Metronidazole
  • Miconazole
  • Mifepristone
  • Mirtazapine
  • Mizolastine
  • Moxifloxacin
  • Nafarelin
  • Nefazodone
  • Nelfinavir
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Paliperidone
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perphenazine
  • Pimavanserin
  • Pipamperone
  • Piperaquine
  • Pitolisant
  • Ponesimod
  • Posaconazole
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Risperidone
  • Ritonavir
  • Rolapitant
  • Saquinavir
  • Selpercatinib
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Thioridazine
  • Tipranavir
  • Tolterodine
  • Toremifene
  • Trazodone
  • Triclabendazole
  • Trimipramine
  • Triptorelin
  • Troleandomycin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vinflunine
  • Voclosporin
  • Voriconazole
  • Vorinostat
  • Ziprasidone
  • Zotepine
  • Zuclopenthixol

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • Abametapir
  • Alefacept
  • Alfentanil
  • Alprazolam
  • Apomorphine
  • Berotralstat
  • Bromazepam
  • Bupropion
  • Butorphanol
  • Calcium Oxybate
  • Cannabidiol
  • Cetirizine
  • Clobazam
  • Conivaptan
  • Dihydrocodeine
  • Doxylamine
  • Eluxadoline
  • Enzalutamide
  • Erdafitinib
  • Esketamine
  • Fentanyl
  • Flibanserin
  • Fosnetupitant
  • Fostemsavir
  • Gabapentin
  • Gabapentin Enacarbil
  • Glucagon
  • Glycopyrrolate
  • Glycopyrronium Tosylate
  • Hydromorphone
  • Imatinib
  • Ketamine
  • Lanreotide
  • Lemborexant
  • Levocetirizine
  • Levorphanol
  • Lithium
  • Lorlatinib
  • Loxapine
  • Lumacaftor
  • Magnesium Oxybate
  • Meperidine
  • Methacholine
  • Milnacipran
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Netupitant
  • Nilotinib
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Pentazocine
  • Periciazine
  • Pixantrone
  • Potassium Oxybate
  • Pregabalin
  • Remifentanil
  • Remimazolam
  • Revefenacin
  • Ribociclib
  • Scopolamine
  • Secretin Human
  • Selegiline
  • Siponimod
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Tiotropium
  • Tramadol
  • Tucatinib
  • Voxelotor
  • Zileuton

Interactions with low risk that usually do not require a change in therapy:

  • Betel Nut
Pimozide FAQs
What is pimozide used for?

Pimozide is primarily used to treat Tourette's syndrome, particularly in cases where other treatments have not been effective. It helps manage the motor and vocal tics associated with the condition.

Yes, pimozide is classified as a typical antipsychotic.

Yes, pimozide is still used. It is primarily prescribed for the treatment of Tourette's syndrome to help control motor and vocal tics. However, its use is generally reserved for cases where other treatments have not been effective, due to its potential side effects and the need for careful monitoring.

Pimozide works by affecting the neurotransmitters in the brain, particularly dopamine. It is an antipsychotic medication that helps to reduce symptoms such as delusions, hallucinations, and tics by blocking dopamine receptors, which can help stabilize mood and behavior.

Yes, weight gain can be a side effect of pimozide. It is important for patients to monitor their weight and discuss any significant changes with their healthcare provider.

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