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The following safety information outlines the potential risks and necessary precautions when using this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Movement Disorders: Use of antipsychotic medications like pimozide can lead to a movement disorder known as tardive dyskinesia, characterized by symptoms such as lip smacking, eye blinking, tongue protrusion, and grimacing. The risk increases with long-term use or high doses and may become permanent. Report any symptoms to your healthcare provider, as they may diminish upon discontinuation of the medication.

• Neuroleptic Malignant Syndrome: This rare but serious condition is associated with antipsychotic medications and presents with high fever, rapid heartbeat, muscle rigidity, and confusion. Immediate medical attention is necessary if these symptoms occur, and your healthcare provider may need to prescribe an alternative medication.

• Increased Infection Risk: Pimozide can decrease white blood cell counts, compromising the body’s ability to fight infections. Regular blood tests will monitor these levels, and the medication may need to be discontinued if they become too low. Notify your healthcare provider if you experience persistent fever or sore throat.

• Heart Rhythm Alterations: Pimozide may cause changes in heart rhythm, observable in ECG scans, especially in individuals treated for Tourette syndrome. Regular heart monitoring is advisable, especially if taking high doses, other heart-affecting medications, or if you have low potassium levels.

Contraindications: Do not use this medication if you have:

• Tics unrelated to Tourette syndrome
• Tics caused by other medications
• Irregular heartbeats
• Comatose states of any origin
• Concurrent use of citalopram, escitalopram, sertraline, macrolide antibiotics, or other drugs that significantly inhibit pimozide breakdown

Consult your healthcare provider if any of these conditions apply to you to avoid serious health risks.

Common side effects:

• drowsiness
• dizziness
• lightheadedness
• dry mouth
• blurred vision
• tiredness
• weakness

Less common but important to monitor:

• muscle stiffness
• shaking
• restlessness
• drooling
• difficulty swallowing
• shuffling walk
• tardive dyskinesia

Serious side effects:

• severe dizziness
• fainting
• slow heartbeat
• seizures
• signs of infection (persistent sore throat or fever)
• increased prolactin levels
• neuroleptic malignant syndrome
• allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)

When taking pimozide, it's important to be aware of potential interactions with other medications, as these can influence how pimozide functions in your body. Some drugs may affect the elimination of pimozide, which can impact its effectiveness. These include medications such as Aprepitant, azole antifungals like Ketoconazole and Itraconazole, HIV protease inhibitors such as nelfinavir, letermovir, Nefazodone, and SSRI antidepressants like Fluvoxamine, paroxetine, and Sertraline. Additionally, medicines like Ritonavir, tucatinib, and zileuton can also interact with pimozide.

Inform your healthcare provider about any other medications you use that could cause drowsiness, such as alcohol, cannabis, antihistamines (for example, Cetirizine or diphenhydramine), sleep or anxiety medications (like Alprazolam, Diazepam, or Zolpidem), muscle relaxants, and opioid pain medications (such as codeine). It's also advisable to check the labels of all your medications, including those for allergies or cold symptoms, since they might contain ingredients that induce drowsiness. Your pharmacist can provide guidance on the safe use of these products.

Moreover, many drugs, in addition to pimozide, can affect heart rhythm (QT prolongation). These include medications such as Amiodarone, Citalopram, Escitalopram, Chlorpromazine, Dofetilide, procainamide, quinidine, ranolazine, Sotalol, and macrolide antibiotics like Clarithromycin and Erythromycin.

Always keep your doctor and pharmacist updated about all the medications, supplements, and over-the-counter products you are taking to ensure safe and effective treatment.