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This document provides important safety information regarding the use of Advair (fluticasone/salmeterol), highlighting potential risks and necessary precautions. Please review these warnings carefully and consult your healthcare provider if you have any questions or concerns.

• Not for Immediate Relief: Advair is not suitable for treating sudden asthma attacks or worsening breathing issues. In such cases, use a rescue inhaler like albuterol (Ventolin HFA) for quick relief.

• Risk of Fungal Infection: Using Advair can lead to thrush, a fungal infection in the mouth and throat, especially if you do not rinse and spit after inhalation. A weakened immune system may increase this risk. If symptoms such as white patches, a cotton-like feeling, pain while eating, swallowing, or loss of taste occur, inform your healthcare provider. They may prescribe medication to treat thrush while continuing Advair.

• Bronchospasm Warning: This medication may cause narrowing of the airways (bronchospasm), leading to breathing difficulty, wheezing, coughing, or chest discomfort. If this occurs, use a rescue inhaler and seek medical attention immediately.

• Increased Infection Risk: Advair, like other corticosteroids, can weaken the immune system, raising the risk for infections such as upper respiratory infections and pneumonia. If you have symptoms like fever, chills, or body aches, contact your provider. Notify them if you are being treated for serious infections like tuberculosis, as alternative medication may be necessary.

• Altered Hormone Levels: Adhere to the prescribed dosage to prevent excessive steroid absorption, which can elevate blood sugar or blood pressure. Long-term or excessive use increases these risks.

• Delayed Growth in Children: Inhaled steroids may slow growth in children. Providers will prescribe the lowest effective dose and monitor growth regularly. Discuss any concerns about growth with your child's provider.

• Eye and Vision Concerns: Long-term use of inhaled steroids may rarely cause eye problems such as increased pressure, glaucoma, or cataracts. Consult an eye specialist if you have a history of these conditions or if vision changes occur.

• Heart-Related Issues: Salmeterol in Advair can affect blood pressure, heart rate, and rhythm, primarily if used excessively. Regular monitoring of these parameters may be recommended for individuals with heart conditions.

• Low Potassium Levels: Excessive use can lead to low blood potassium, causing symptoms like fatigue, cramps, rapid heartbeat, or tingling sensations. Report these symptoms and any increased usage needs to your provider for possible treatment adjustments.

• Allergic Reactions: Severe allergic reactions, including facial swelling, shock, and anaphylaxis, are possible. Seek immediate medical help if you experience hives, rash, red skin, swelling of lips or tongue, or breathing difficulties.

This medication should not be used for sudden, severe asthma attacks, or if you have allergies to fluticasone, salmeterol, lactose, or milk proteins. Always consult your healthcare provider if any of these conditions apply to you.

When taking this medication, some individuals may experience common side effects which are generally mild. These include upper respiratory infections, sore throat, headache, bronchitis, cough, nausea, vomiting, and hoarseness. If these symptoms persist or worsen, it's advisable to consult your healthcare provider for further guidance.

Other side effects that have been reported include throat irritation, muscle and bone pain, and stomach discomfort. While these occur less frequently, monitoring your symptoms and discussing them with your healthcare provider if they become bothersome is important.

There are also rare but serious side effects that require immediate medical attention. These include sudden worsening of breathing problems or asthma, chest pain, fast or irregular heartbeat, severe dizziness, fainting, and seizures. Additionally, symptoms indicating an allergic reaction, such as rash, itching, swelling (particularly of the face, tongue, or throat), or trouble breathing, necessitate urgent medical care.

In some cases, individuals may experience oral thrush, characterized by white patches in the mouth, or signs of infection such as a persistent sore throat and fever. Mental or mood changes, vision problems, increased thirst or urination, muscle cramps, and shaking (tremors) are also noted as serious side effects. Always seek medical help if you encounter any of these symptoms to ensure timely and appropriate care.