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The following safety information outlines the potential risks and necessary precautions associated with the use of levetiracetam (Keppra). It is important that you review these details carefully and consult your healthcare provider if you have any concerns or questions.

• Mood and Behavioral Changes: Levetiracetam (Keppra) may cause changes in mood or behavior, including irritability, aggression, anxiety, paranoia, depression, or withdrawal. Report any significant mood or behavioral changes to your provider. This is particularly important for children and individuals with a history of mental health disorders such as depression, schizophrenia, or bipolar disorder.

• Suicidal Thoughts or Behaviors: There is an increased risk of suicidal thoughts or behaviors when taking levetiracetam (Keppra), which may emerge as soon as one week after starting the medication. Seek immediate medical attention if you or someone around you notices suicidal thoughts or behavior, anxiety, panic attacks, insomnia, anger, or restlessness. This risk is heightened when taking other anti-seizure medications.

• Cognitive and Motor Impairment: Levetiracetam (Keppra) can affect brain function, leading to difficulty with concentration, speech, and coordination. Dizziness and sleepiness are also possible, which can impair thinking and reaction times. The risk is greater with high doses, immediate-release formulations, or concurrent use of medications that cause drowsiness or dizziness, such as benzodiazepines, muscle relaxants, or sleep aids.

• Severe Allergic Reactions: Serious allergic reactions, including anaphylaxis and severe skin conditions like Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN), can occur. Seek emergency medical care if you experience facial swelling or any signs of a severe allergic reaction.

• Withdrawal Seizures: Do not abruptly discontinue levetiracetam (Keppra) without consulting your healthcare provider, as sudden cessation can result in withdrawal seizures. If discontinuation is necessary, your provider will guide you on gradually reducing the dosage.

• Blood Cell Count Reduction: Although rare, levetiracetam (Keppra) may lower blood cell counts, increasing the risk of anemia, infections, and bleeding. Your provider may conduct blood tests to monitor blood cell levels. Contact your provider if you experience symptoms such as fever, shortness of breath, chills, weakness, unusual bruising or bleeding, or blood in urine, stools, or gums.

• Increased Blood Pressure in Young Children: Levetiracetam (Keppra) can raise blood pressure in children under 4 years. Regular blood pressure monitoring may be necessary. Report any significant increases in blood pressure to your child's healthcare provider.

• Seizure Management During Pregnancy: The effectiveness of levetiracetam (Keppra) may decrease during pregnancy, particularly in the third trimester, due to lower medication levels in the body. Pregnant individuals should have regular consultations with their healthcare provider to manage seizure control and may require dosage adjustments.

Please note that there are no specific contraindications listed for levetiracetam (Keppra) in the provided data. Always consult your healthcare provider for personalized medical advice.

When taking this medication, some individuals may experience common side effects. For adults, these include feelings of weakness and sleepiness, each affecting about 15% of users, as well as headaches (14%), infections (13%), and dizziness (9%). While these effects are generally mild and temporary, it is advised to contact a healthcare provider if they persist or worsen.

Children may also experience common side effects such as headaches (19%), symptoms resembling a common cold (15%), vomiting (15%), sleepiness (13%), and tiredness (11%). Additionally, some children may feel more aggressive (10%) or irritable (7%), have a stuffy nose (9%), or experience a lowered appetite (8%). Most of these side effects are mild, but staying in touch with a healthcare provider can help manage any concerns.

There are also other side effects reported, such as those previously listed. However, some side effects can be more serious and require immediate medical attention. If you or your child experiences severe symptoms, such as persistent headaches, significant changes in mood or behavior, or pronounced physical discomfort, it is crucial to seek urgent medical care. Always prioritize health and communicate with healthcare professionals regarding any troubling symptoms.