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Antidepressant medications are prescribed to manage various conditions, such as depression and other mental or mood disorders. While these drugs can be beneficial by reducing suicidal thoughts and improving mood, there is a small risk associated with their use, particularly in individuals under 25 years of age. Some may experience an increase in depression, changes in mood, or even suicidal thoughts or behaviors.

• It is crucial to discuss the potential risks and benefits of antidepressants with a healthcare provider, especially for those younger than 25, even if the medication is not being used to treat a mental or mood disorder.
• Contact a healthcare professional immediately if you or someone you are caring for exhibits signs of worsening depression, unusual behavioral changes, or mental health symptoms such as new or increased anxiety, panic attacks, insomnia, irritability, hostility, impulsivity, severe restlessness, or rapid speech.
• Increased vigilance is necessary when beginning a new antidepressant or adjusting the dosage to monitor any adverse effects.

This guidance ensures both patients and caregivers are informed and prepared to address any issues that may arise during treatment with antidepressant medications.

This medication may cause some common side effects, which are generally mild and easy to manage. These include drowsiness, dizziness, nausea, dry mouth, constipation, loss of appetite, weight loss, blurred vision, nervousness, trouble sleeping, and excessive sweating. If these effects persist or worsen, it is advisable to consult with a healthcare professional. Occasionally, you might notice an empty tablet shell in your stool, which is harmless as the medication has already been absorbed.

Be aware that this medication can increase blood pressure, so regular monitoring is essential. Report any high readings to your healthcare provider. Although many individuals do not experience serious side effects, it is important to be vigilant. Serious side effects such as severe headaches, tremors, decreased interest in sex, changes in sexual function, or easy bleeding/bruising should be reported promptly.

Very serious side effects, though rare, require immediate medical attention. These include persistent cough, shortness of breath, chest pain, black stools, vomit resembling coffee grounds, eye pain, widened pupils, vision changes, or seizures. This medication may increase serotonin levels, occasionally leading to a condition known as serotonin syndrome. Symptoms include rapid heartbeat, hallucinations, loss of coordination, severe dizziness, nausea, vomiting, diarrhea, muscle twitching, fever, and unusual agitation. Immediate medical help is crucial if these occur.

Allergic reactions to this medication are rare but can be severe. Seek immediate assistance if you experience symptoms such as rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. Always communicate any unusual side effects to your healthcare provider for further guidance.

Certain medications can interact with this drug. If you are taking other medications that increase the risk of bleeding or bruising, such as antiplatelet drugs like Clopidogrel, NSAIDs like Ibuprofen or Naproxen, or blood thinners such as Dabigatran or Warfarin, please inform your doctor. Using Aspirin alongside this medication can also heighten the bleeding risk. However, if your doctor has advised you to take low-dose aspirin (typically 81-162 milligrams daily) to prevent heart attacks or strokes, continue as directed unless instructed otherwise. Consult your healthcare provider for more information.

Avoid using MAO inhibitors, including isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine, during treatment with this medication, as it may lead to a severe and potentially fatal interaction. Most MAO inhibitors should not be taken two weeks prior to and at least seven days after the treatment. Discuss with your doctor about when to start or stop this medication.

The risk of serotonin syndrome or toxicity may increase if you are also using other drugs that raise serotonin levels. This includes certain street drugs like MDMA/"ecstasy," St. John's wort, some antidepressants (including other SNRIs such as Duloxetine or milnacipran, SSRIs such as Fluoxetine or paroxetine), and Tryptophan. The risk is heightened when starting or increasing the dose of these medications.

Inform your doctor or pharmacist if you are using other products that cause drowsiness, such as opioid pain or cough relievers (e.g., codeine, hydrocodone), alcohol, marijuana (cannabis), sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or antihistamines (e.g., Cetirizine, diphenhydramine). Check product labels for ingredients that may cause drowsiness and consult your pharmacist about safe usage.

Do not use medications containing Venlafaxine while taking desvenlafaxine, as they are very similar.

This medication may affect the results of certain lab tests, including urine tests for amphetamines, leading to possible false results. Ensure that lab personnel and all your healthcare providers are aware that you are using this medication.