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This medication has specific safety warnings and precautions that you need to be aware of. Below is a summary of the critical information regarding the use of this drug:

• Potential for Misuse and Dependence: This medication carries a risk of misuse and dependence. Misuse, which involves using the drug in a manner not prescribed, can lead to severe side effects like increased heart rate, high blood pressure, aggressive behavior, and even thoughts of self-harm or harm to others. It's particularly risky for individuals with a history of substance or alcohol use disorders. Abruptly stopping the medication can lead to withdrawal symptoms; consult your healthcare provider for guidance.

• Serious Heart Problems: There is a risk of sudden death, stroke, and heart attack in individuals taking stimulants at recommended doses. This medication can also cause increased blood pressure and heart rate. If you have a history of heart problems, discuss this with your healthcare provider to ensure the medication is safe for you. Seek immediate medical attention if you experience fainting, chest pain during physical activity, or an irregular heartbeat.

• Behavioral Changes: Some individuals may experience mental health issues such as hallucinations, unclear thinking, or mania. These symptoms could worsen existing mental health conditions or emerge in individuals without a prior history. Notify your healthcare provider if you notice any mood or behavior changes.

• Growth Impact in Children: Stimulants can affect growth in children, leading to weight loss and slowed growth in height and weight. Regular monitoring of your child’s growth is recommended. If there are concerns about slowed growth, nutritional intake, or significant weight changes, consult your child’s healthcare provider.

• Blood Circulation Issues: The medication may cause blood circulation problems such as Raynaud's phenomenon, which affects blood flow to the fingers and toes, causing color changes and discomfort. Although usually mild, inform your provider if these symptoms occur, as adjusting the dose may be necessary.

• Serotonin Syndrome Risk: This potentially life-threatening condition can occur if the medication is combined with others that affect serotonin levels, such as certain antidepressants and migraine medications. Symptoms include rapid heart rate, sweating, muscle spasms, fever, and confusion. Seek emergency medical help if you experience these symptoms.

• Drug Interactions: The medication can interact with various prescription and over-the-counter drugs, such as sodium bicarbonate products and monoamine oxidase inhibitors (MAOIs), potentially increasing side effects or causing severe high blood pressure. Discuss all current medications with your healthcare provider before starting this medication, and avoid starting new medications without professional advice.

• Contraindications: Do not use this medication if you have a severe allergy to amphetamine-containing products or if you have used MAOIs, linezolid, or methylene blue in the past 14 days. Consult your healthcare provider if you have any of these conditions.

It is crucial to follow your healthcare provider’s instructions and regularly consult them to manage your treatment safely.

When taking this medication, you may experience some common side effects, which are typically mild. These include nausea, vomiting, constipation, stomach or abdominal pain, loss of appetite, dry mouth, headache, feelings of nervousness or dizziness, trouble sleeping, sweating, weight loss, irritability, and restlessness. It's important to monitor these symptoms, and if they persist or worsen, consult your healthcare provider for advice.

Some individuals may notice an increase in blood pressure, so regular monitoring is advised. Serious side effects are rare but require immediate medical attention and include blurred vision, irregular heartbeat, significant mood or behavior changes (such as depression or suicidal thoughts), uncontrolled movements, and symptoms indicating blood flow problems in the extremities, such as coldness or numbness in fingers or toes.

Additionally, there is a risk of serotonin syndrome, a severe condition marked by symptoms such as a rapid heartbeat, hallucinations, severe dizziness, and unexplained fever. If you encounter any of these or experience a very serious allergic reaction characterized by a rash, swelling, or difficulty breathing, seek medical help right away. Always inform your healthcare provider of all medications you are taking to avoid adverse interactions. This summary is not exhaustive, so contact your doctor or pharmacist if you notice other effects.

It is crucial to avoid using MAO inhibitors, such as isocarboxazid, linezolid, and selegiline, while taking this medication, as this could lead to a serious, potentially fatal reaction. Most MAO inhibitors should be discontinued at least two weeks prior to starting this medication. Consult your doctor to determine the appropriate timing for stopping or starting these treatments.

Certain products, particularly those for cough, cold, or weight loss, might contain ingredients that can elevate heart rate or blood pressure. It's important to inform your pharmacist about any products you're using to ensure they are safe in combination with this medication.

The risk of developing serotonin syndrome, a potentially severe condition, increases if you are taking other medications that boost serotonin levels. This includes certain antidepressants like SSRIs (e.g., fluoxetine, paroxetine) and SNRIs (e.g., duloxetine, venlafaxine), as well as substances like MDMA or St. John's wort. The risk is particularly high when starting or increasing the dosage of these medications.

Lisdexamfetamine is closely related to amphetamine and dextroamphetamine. Therefore, you should not take other medications containing these substances while using lisdexamfetamine.

Additionally, this medication may interfere with certain laboratory tests, such as those measuring blood and urine steroid levels, potentially leading to inaccurate results. It's important to inform lab personnel and all your healthcare providers that you are taking this medication.