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You might experience some common side effects such as loss of appetite, weight loss, dry mouth, stomach upset or pain, nausea, vomiting, dizziness, headache, diarrhea, fever, nervousness, and trouble sleeping. These effects are generally mild, but if they persist or worsen, it is important to inform your healthcare provider.

This medication can lead to an increase in blood pressure, so regular monitoring is recommended. If you notice any significant changes, seek medical advice. Serious side effects are not common but require immediate attention. These include symptoms like coldness, numbness, or color changes in fingers or toes, unusual wounds, behavioral changes, uncontrolled movements, changes in sexual function, or prolonged erections in males.

In rare cases, very serious side effects may occur. These require urgent medical assistance and include symptoms such as shortness of breath, chest pain, fainting, severe headache, irregular heartbeat, seizures, swelling of the ankles or feet, extreme fatigue, blurred vision, one-sided body weakness, difficulty speaking, or confusion.

Additionally, the medication may increase serotonin levels, potentially leading to serotonin syndrome, especially if combined with other serotonin-boosting drugs. Be vigilant for symptoms like rapid heartbeat, hallucinations, loss of coordination, severe dizziness, nausea, vomiting, diarrhea, muscle twitching, unexplained fever, or unusual agitation.

Allergic reactions are rare but serious. Seek immediate help if you experience a rash, itching, swelling, severe dizziness, or trouble breathing. This summary does not include all possible side effects. If you observe any other unusual effects, contact your healthcare provider for guidance.

Avoid using MAO inhibitors with this medication, as it can lead to a severe and potentially life-threatening reaction. This includes medications such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine. Do not take MAO inhibitors while on this medication, and most should be stopped at least two weeks prior. Consult your doctor for guidance on when to start or stop this medication.

Some products may contain ingredients that could increase your heart rate or blood pressure. Discuss any products you are using with your pharmacist, especially cough and cold remedies or diet aids, to ensure safe use.

The risk of developing serotonin syndrome or toxicity can rise if you are taking other drugs that increase serotonin levels. This includes substances like MDMA ("ecstasy"), St. John's wort, and certain antidepressants, such as SSRIs (like Fluoxetine or paroxetine) and SNRIs (like Duloxetine or Venlafaxine). The risk is higher when starting or increasing the dose of these drugs.

Dextroamphetamine is very similar to Lisdexamfetamine, so you should not use both medications simultaneously.

This medication might interfere with certain medical or laboratory tests, such as blood and urine steroid levels or brain scans for Parkinson's disease, potentially leading to inaccurate results. Inform lab personnel and your doctors that you are using this medication.