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Taking this medication may cause some common side effects such as drowsiness, dizziness, increased saliva production, nausea, constipation, or changes in sexual desire or ability. If these effects persist or worsen, it is important to consult a healthcare provider for advice. To minimize dizziness and lightheadedness, try to stand up slowly after sitting or lying down.

While many individuals using this medication do not experience serious complications, it is crucial to be aware of potential severe side effects. Contact a healthcare professional immediately if you experience mental or mood changes like hallucinations or thoughts of self-harm, difficulty speaking, loss of coordination, trouble walking, or memory issues.

In rare cases, very serious side effects such as yellowing of the eyes or skin, or seizures, may occur. If these happen, seek medical attention right away. Additionally, although uncommon, an allergic reaction could occur. Symptoms include a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing, and require immediate medical intervention.

This summary does not cover all possible side effects. If you experience other unusual symptoms, reach out to a healthcare provider for guidance.

Certain products can interact with this medication, including kava and sodium oxybate. Other drugs may influence how alprazolam is processed in your body, potentially altering its effectiveness. These include adagrasib, some azole antifungals (like itraconazole, ketoconazole), cimetidine, certain antidepressants (such as fluoxetine, fluvoxamine, nefazodone), protease inhibitors (like indinavir), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John's wort, and seizure medications (such as phenytoin).

Taking alprazolam with other substances that also cause drowsiness or breathing difficulties could raise the risk of severe side effects, like slowed or shallow breathing and intense drowsiness or dizziness. Inform your doctor or pharmacist if you are using any other products that could cause these effects, such as opioid pain or cough medications (like codeine, hydrocodone), alcohol, cannabis, other sleep or anxiety medications (such as diazepam, lorazepam, zolpidem), muscle relaxants (like carisoprodol, cyclobenzaprine), or antihistamines (like cetirizine, diphenhydramine).

Always check the labels on your medications, including those for allergies or cough and cold, to ensure they don’t contain ingredients that can make you drowsy. Consult your pharmacist to safely use these products. Additionally, smoking can reduce the levels of this medication in your blood. Inform your doctor if you smoke or have recently quit smoking.