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The following safety guidelines are essential to ensure the safe use of the medication dorzolamide. Please read them thoroughly and consult your healthcare provider with any questions or concerns.

• Severe Allergic Reactions: Although primarily absorbed through the eye, a small amount of dorzolamide may enter the bloodstream. If you have a known allergy to sulfa medications, be aware that dorzolamide is a sulfa-based drug, and you may experience a severe allergic reaction. Seek immediate medical attention if you notice symptoms such as difficulty breathing, skin rash, redness, itching, or swelling. Alert your healthcare provider if you experience irritation, pain, or itching in or around your eyes. Risk: Sulfa allergy.

• Risk of Eye Infection Due to Contamination: To prevent contamination, wash your hands before each application of dorzolamide. Avoid letting the bottle tip contact your eye or any surface, and do not touch the dropper tip with your hands. Contaminated medication can lead to eye infections, like bacterial keratitis, which is an infection of the cornea. Risk: Corneal disease, injury, or damage to the eye surface.

• Risk of Corneal Swelling: Dorzolamide may increase the risk of corneal swelling (corneal edema) in certain individuals. If you have been informed by an eye specialist that your cornea is thin or you have a low number of cells on the cornea, discuss these conditions with your eye specialist before starting dorzolamide. Risk: Low number of cells on the cornea.

There are no contraindications available for this medication. Always adhere to the prescribed guidelines and consult your healthcare provider for personalized advice.

Common side effects:

• Temporary blurred vision
• Burning of the eye
• Stinging of the eye
• Redness of the eye
• Itching
• Watery eyes
• Dry eyes
• Sensitivity to light
• Bitter taste
• Headaches

Less common but important to monitor:

• Bacterial eye infections
• Allergic reactions in the eye
• Eyelid irritation
• Pink eye

Serious side effects:

• Vision changes
• Symptoms of kidney stones
• Yellowing of the skin or eyes
• Dark urine
• Unusual tiredness
• Signs of infection
• Severe allergic reactions
• Eye redness or discharge
• Eye or eyelid swelling
• Difficulty breathing

When using dorzolamide eye drops, it's important to be aware of potential interactions with other medications and certain health conditions. Dorzolamide is a carbonic anhydrase inhibitor that reduces intraocular pressure by decreasing fluid production in the eye.

Drug Interactions:

• Oral Carbonic Anhydrase Inhibitors: Combining dorzolamide with oral carbonic anhydrase inhibitors like Acetazolamide or Methazolamide can increase the risk of side effects.

• Salicylates: Medications containing salicylates, such as Aspirin or Bismuth Subsalicylate, may interact with dorzolamide, potentially leading to metabolic acidosis.

Disease Interactions:

• Kidney and Liver Conditions: Individuals with severe kidney or liver disease should use dorzolamide cautiously, as the medication is processed through these organs.

• Sulfonamide Allergy: Dorzolamide is a sulfonamide derivative. Those with a known sulfonamide allergy may experience allergic reactions and should consult their healthcare provider before use.

• Blood Disorders: Patients with blood dyscrasias or bone marrow suppression should be cautious, as sulfonamides can be systemically absorbed and may cause hematologic toxicity.

• Porphyria: Individuals with porphyria should use dorzolamide with caution, as sulfonamides can precipitate an acute attack.

Always inform your healthcare provider about all medications you're taking and any existing health conditions to ensure dorzolamide is safe and effective for you.