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When considering the use of this medication, it is crucial to be aware of several safety concerns and warnings that can impact your health. Below are important aspects to consider:

• Smoking and Heart Risks: If you are 35 years or older and smoke cigarettes, using hormonal contraceptives like Enskyce can significantly increase your risk of serious cardiovascular issues, including heart attacks, strokes, and blood clots. The risk grows with the number of cigarettes smoked. It is advisable to discuss alternative birth control methods with your healthcare provider if you are a smoker.

• Blood Clots and Related Complications: Enskyce may elevate the risk of developing blood clots, which could lead to conditions such as deep vein thrombosis (DVT) or pulmonary embolism (PE). This risk is heightened for those over 35 who smoke, individuals over 40 who do not smoke, those recovering from surgery with extended bed rest, postpartum women, and those with obesity, high blood pressure, high cholesterol, or diabetes.

• Cancer Risks: There is a potential increased risk of breast and cervical cancer associated with long-term use of Enskyce. Individuals with a personal or family history of breast cancer should exercise caution and consult their healthcare provider.

• Liver Concerns: Individuals with liver issues should avoid using Enskyce as it may contribute to liver damage or benign liver tumors. Those on certain hepatitis C medications should also be cautious.

• Blood Sugar and Cholesterol Levels: Enskyce may elevate blood sugar and cholesterol levels, particularly for individuals with prediabetes or diabetes. Monitoring these levels is recommended.

• Blood Pressure: The use of Enskyce can lead to increased blood pressure, especially in older adults or those using the medication long-term.

• Headaches: New or worsening migraines and persistent headaches should be discussed with a healthcare provider.

• Irregular Bleeding: Breakthrough bleeding is common during the initial months of use. Any unusual vaginal bleeding should be reported to a healthcare provider.

• Depression: If symptoms of depression worsen, consult with your healthcare provider, as medication adjustments may be necessary.

• Drug Interactions: Inform your healthcare provider about all other medications you are taking, as some can reduce the effectiveness of Enskyce or increase its side effects. Backup contraception may be needed when using interacting medications.

• Contraindications: Do not use Enskyce if you have a history of blood clots, certain heart conditions, uncontrolled high blood pressure, diabetes with complications, certain headaches, a history of certain cancers, jaundice, liver problems, or if you are pregnant.

If any of these warnings apply to you, it is essential to discuss them with your healthcare provider to ensure safe and effective use of the medication.

When taking this medication, you may experience a range of side effects. Common and generally mild effects include nausea, vomiting, headache, bloating, and breast tenderness. Some individuals may notice changes in weight or menstrual flow, spotting or breakthrough bleeding, stomach cramps, or swelling of the ankles and feet due to fluid retention. If these symptoms persist or worsen, it is advisable to consult your healthcare provider for guidance.

There are also other side effects that, while less common, can occur. These include changes in appetite or sex drive, acne, yeast infections, trouble wearing contact lenses, and spotty darkening of the skin. This medication might also lead to higher blood pressure or feelings of depression, so it's important to monitor these conditions and report any concerns to your healthcare provider.

More serious side effects, although rare, require immediate medical attention. These include signs of heart attack such as chest pain and dizziness, or stroke symptoms like sudden numbness or weakness. Blood clots can manifest as leg pain or swelling, or trouble breathing if they reach the lungs. Severe liver issues may present as yellowing of the skin or eyes, and significant stomach pain. Additionally, a rare but serious allergic reaction may occur, marked by rash, itching, swelling, severe dizziness, or breathing difficulties. If you experience any of these severe symptoms, seek urgent medical care promptly.

When taking Enskyce, it's crucial to be aware of potential interactions with other medications or supplements. Always inform your doctor and pharmacist about all the drugs you are using, including prescription, over-the-counter medications, vitamins, and herbal products.

Some drugs can decrease the effectiveness of hormonal birth control like Enskyce, leading to unintended pregnancy. These include medications such as griseofulvin, Modafinil, certain rifamycins (like Rifampin and Rifabutin), Ritonavir, St. John's wort, and drugs used for seizures (like barbiturates and Carbamazepine), as well as certain HIV medications (such as nelfinavir and Nevirapine). Discuss with your doctor if additional contraceptive methods are needed and report any unusual bleeding as it may signal reduced birth control effectiveness.

Enskyce may also interact with other medications, which might require changes in dosage or usage. These include, but are not limited to, dasabuvir, ombitasvir, paritaprevir, and Tranexamic Acid. Using Enskyce with these drugs is generally not recommended due to possible adverse effects.

Additionally, Enskyce might interfere with lab tests, potentially causing inaccurate results, especially in blood clotting and thyroid tests. Ensure that all healthcare providers are aware that you are using this medication.