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When using flunisolide nasal spray, it is essential to be aware of important safety information and potential risks associated with its use. The following points highlight key warnings and precautions to keep in mind:

• Changes in Stress Hormone Levels: Prolonged use or excessive amounts of flunisolide can lead to increased absorption of the medication into the body, acting like the natural stress hormone cortisol. High cortisol levels may result in symptoms such as abdominal weight gain, fatty deposits in the face and upper back, and fatigue. This risk is heightened if you are using flunisolide long-term, using excessive amounts, initiating flunisolide after extended steroid pill use, or concurrently taking prednisone every other day.

• Risk of Infection: Flunisolide may impair the immune system's ability to combat infections, potentially making you more susceptible to illness. Some users in clinical studies developed nasal and throat thrush, a type of fungal infection. Other infections, including bacterial and viral, may also occur, especially if you are taking additional medications that suppress the immune system. This risk is greater with prolonged use, existing untreated infections, active or dormant tuberculosis, viral eye infections, or concurrent use of immune-weakening medications.

• Slowed Wound Healing: As a steroid medication, flunisolide can delay the healing process of wounds. Since it is applied directly to the nasal area, it may lengthen the healing time for nasal wounds. This risk is particularly relevant if you have had recent nasal surgery, nose injuries, frequent nosebleeds, or nasal ulcers.

• Delayed Growth in Children: Steroid nasal sprays like flunisolide may slow growth in children. The long-term impact on their final adult height remains uncertain. The risk is increased with higher doses and prolonged use of flunisolide.

Consult your healthcare provider for personalized advice and if you have any concerns regarding these warnings.

Common side effects:

• Burning sensation in the nose
• Stinging sensation in the nose

Less common but important to monitor:

• Sneezing
• Stuffy nose
• Nosebleeds
• Nasal irritation
• Watery eyes
• Sore throat
• Headaches
• Nausea
• Vomiting
• Temporary loss of smell
• Permanent loss of smell
• Temporary loss of taste
• Permanent loss of taste

Flunisolide, a corticosteroid used to manage respiratory conditions, can interact with various medications, potentially altering its effectiveness or increasing the risk of side effects. It's important to be aware of these interactions to ensure safe and effective treatment.

Certain medications can increase flunisolide levels in the body, leading to a higher likelihood of side effects such as swelling, weight gain, high blood pressure, elevated blood sugar, muscle weakness, mood changes, skin thinning, easy bruising, bone density loss, and eye problems like cataracts. Notable examples include Clarithromycin and Itraconazole. If you're prescribed these drugs alongside flunisolide, your doctor may adjust your dosage or monitor you more closely.

Conversely, some medications may decrease flunisolide's effectiveness by lowering its concentration in the body. These include barbiturates, Carbamazepine, Phenytoin, and Rifampin. If you're taking any of these, inform your healthcare provider, as they might need to modify your treatment plan.

Additionally, combining flunisolide with certain drugs can increase the risk of specific side effects. For instance, using Aspirin or other salicylates with flunisolide may heighten the risk of gastrointestinal bleeding. Similarly, combining flunisolide with diuretics like Hydrochlorothiazide can lead to low potassium levels, which may cause muscle weakness or irregular heartbeats.

It's also important to note that flunisolide can suppress the immune system, potentially increasing susceptibility to infections. Therefore, avoid close contact with individuals who have contagious illnesses like chickenpox or measles while using this medication.

Always inform your healthcare provider about all medications, supplements, and herbal products you're currently taking. This information helps them manage potential interactions and adjust your treatment as necessary. Never start or stop any medication without consulting your doctor.