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When using Gralise (gabapentin), it is crucial to be aware of several safety warnings and potential risks. If you have any questions or concerns, consult your healthcare provider to ensure safe use of this medication.

• Cognitive and Motor Impairment: Gralise may cause dizziness, sleepiness, and difficulty concentrating, which could impair your ability to think, react, and focus. These effects typically improve after a few weeks. The risk increases if you are taking other sedative medications like benzodiazepines, muscle relaxants, or sleep aids. Avoid driving or engaging in activities that require alertness until you know how the medication affects you. Contact your healthcare provider if excessive drowsiness occurs.

• Increased Risk of Suicidal Thoughts: Gralise may elevate the risk of suicidal thoughts or behaviors, potentially occurring as soon as one week after starting the medication. If you or someone around you notices symptoms such as depression, anxiety, panic attacks, anger, irritability, or restlessness, seek immediate medical attention.

• Respiratory Depression: Combining Gralise with alcohol or other medications that depress the central nervous system, such as opioids and benzodiazepines, can lead to dangerously slow breathing. If you experience difficulty breathing, or notice bluish lips, fingers, or toes, seek emergency medical help immediately.

• Severe Allergic and Skin Reactions: Severe allergic reactions, including facial swelling and anaphylaxis, are rare but possible. Serious skin reactions like DRESS syndrome can also occur. Discontinue use and seek medical attention if you experience fever, facial swelling, difficulty breathing, rash, blisters, swollen lymph nodes, or skin peeling.

• Withdrawal Symptoms: Abruptly discontinuing Gralise may lead to withdrawal symptoms such as nausea, anxiety, nervousness, and irregular heart rhythms. These are more likely if you have been on the medication for a prolonged period. Consult your healthcare provider before altering your dose, as they may recommend gradually tapering off the medication.

There are no specific contraindications listed for Gralise, but always discuss your medical history with your healthcare provider before starting any new medication.

When taking this medication, you may experience some common side effects such as dizziness and sleepiness, which usually are mild. These might affect a small percentage of users, but if they persist or become bothersome, it's advisable to consult with your healthcare provider. Other side effects that have been reported include headaches, diarrhea, dry mouth, common cold symptoms, and weight gain. Swelling in the hands, feet, or ankles, as well as pain in the arms, legs, or back, can also occur.

While many people do not experience serious side effects, it's important to be aware of them. Some users may notice swelling in their extremities, which should be reported to a healthcare professional immediately. A small number of individuals on anticonvulsants may experience mental health changes, such as depression, suicidal thoughts, or sudden mood alterations. If you or those around you observe any unusual changes in behavior or thoughts, contact a healthcare provider immediately.

In rare cases, this medication can cause severe allergic reactions or skin issues, which may present as hives, rash, blisters, or skin reddening. If you experience these symptoms, along with fever, swollen lips or tongue, or difficulty breathing, seek urgent medical help. Additionally, slow or shallow breathing is a very serious side effect that warrants immediate medical attention. If you notice any side effects not listed here, it's crucial to discuss them with your doctor or pharmacist.

Gralise (gabapentin) can interact with a variety of medications and substances. It is important to inform your doctor and pharmacist about all the medications and supplements you are taking, whether they are prescription, over-the-counter, vitamins, or herbal supplements.

One medication that may interact with Gralise is orlistat. Combining Gralise with certain substances can increase the risk of serious side effects such as slow or shallow breathing, or severe drowsiness and dizziness. You should be cautious if you are taking other products that cause drowsiness or affect breathing, including opioid pain or cough relievers (like codeine or hydrocodone), alcohol, marijuana, sleep or anxiety drugs (such as alprazolam, lorazepam, or zolpidem), muscle relaxants (such as carisoprodol or cyclobenzaprine), and antihistamines (like cetirizine or diphenhydramine).

Additionally, Gralise should not be used with medications that contain gabapentin, including gabapentin enacarbil, as this could lead to undesirable effects. Always check the labels of your medicines for ingredients that may cause drowsiness and consult your pharmacist for safe use.

Gralise may also interfere with certain laboratory tests, potentially leading to incorrect results. Therefore, it's important to inform lab personnel and all your healthcare providers that you are using this medication.