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The following safety warnings and precautions are essential for those considering or currently using digoxin (Lanoxin). Please read them carefully and discuss any concerns with your healthcare provider to ensure safe use of this medication.

• Abnormal Heart Rhythm: Digoxin may cause serious heart rhythm issues, including ventricular fibrillation, slow heart rate, and heart block. These conditions can be life-threatening, particularly in individuals with a history of heart rhythm problems. It is crucial to inform your healthcare provider of your complete medical history prior to starting digoxin. If you are undergoing electrical treatment for atrial fibrillation, you may need to pause digoxin 1 or 2 days before the procedure. Seek immediate medical help if you experience symptoms such as chest pain, palpitations, shortness of breath, or excessive sweating. People at higher risk include those with Wolff-Parkinson-White syndrome, a history of heart rhythm problems, or those taking other heart-affecting medications.

• Digoxin Toxicity: Excessive levels of digoxin in the body can lead to toxicity. Healthcare providers will monitor kidney function and digoxin blood levels regularly to confirm the correct dosage. Symptoms like nausea, vision changes, confusion, or abnormal heart rates require prompt medical attention. Individuals with low body weight, older age, kidney issues, or imbalances in potassium, magnesium, or calcium levels are at increased risk, as well as those on medications that elevate digoxin levels.

• Worsening Heart Conditions: Those with specific heart conditions should avoid digoxin due to the potential for symptom exacerbation. Disclose all health problems to your provider to ensure digoxin is appropriate for you. Conditions of concern include past heart attacks, myocarditis, cardiomyopathy, pericarditis, and amyloid heart disease.

• Reduced Efficacy with Low Calcium Levels: Digoxin’s effectiveness diminishes with low calcium levels. If your calcium is low, treatment to normalize these levels may be necessary for optimal medication performance.

• Variability in Thyroid and Metabolism Issues: Individuals with hypothyroidism typically require lower doses of digoxin. Conversely, those with atrial fibrillation related to hyperthyroidism or metabolic issues may not respond well to digoxin, and addressing the underlying condition is prioritized.

Contraindications: Digoxin should not be used in individuals with ventricular fibrillation, a severe type of abnormal heart rhythm, due to significant health risks. Always consult your healthcare provider if this condition applies to you.

When taking this medication, be aware of potential side effects, which vary in severity. Common side effects include changes in heart rate, nausea, vomiting, diarrhea, and reduced appetite. These symptoms are usually mild, but if they persist or become bothersome, it is advisable to seek guidance from a healthcare provider.

Other side effects that some users may encounter include headache, weakness, dizziness, confusion, rash, and enlarged male breasts. Although these symptoms are generally manageable, it is important to consult a healthcare professional if they occur, especially if they are severe or persistent.

Serious side effects, while rare, require immediate medical attention. These include abnormal heart rhythm, which may present as chest pain, discomfort, palpitations, shortness of breath, fatigue, weakness, or sweating. Additionally, digoxin toxicity is a concern, characterized by symptoms such as nausea, vomiting, loss of appetite, changes in vision, confusion, palpitations, or an abnormally slow heart rate. Seeking urgent medical care is crucial if any of these symptoms arise.