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Amiodarone is a medication often used to treat irregular heartbeats, but it carries potential risks and requires careful monitoring. Below are important safety warnings and precautions to consider when using this medication:

• Heart Risks: Amiodarone may rarely worsen irregular heartbeats or cause life-threatening arrhythmias. It should only be taken for serious heart conditions with regular follow-up by a cardiologist. Electrolyte levels should be checked before starting treatment, and regular ECG tests may be required. Seek immediate medical attention if you experience chest pain, dizziness, fainting, or a rapid heartbeat.

• Lung Damage: The drug can cause serious lung inflammation. A chest x-ray may be conducted before starting the medication, followed by monitoring every 3 to 6 months. Report any persistent cough, shortness of breath, wheezing, or chest tightness to a healthcare professional promptly.

• Liver Damage: Though rare, amiodarone can lead to liver damage. Liver enzyme levels will be monitored before and during treatment. Alert your healthcare team if you experience severe nausea, vomiting, right-sided stomach pain, fatigue, loss of appetite, or yellowing of the skin or eyes.

• Vision Problems: Serious vision issues, including blindness, can occur. Regular eye exams are recommended. Contact an eye specialist if you notice blurred vision, difficulty seeing peripherally, or halos around lights.

• Thyroid Issues: Amiodarone can alter thyroid hormone levels, causing either hyperthyroidism or hypothyroidism. Regular thyroid function tests are necessary during treatment.

• Slow Heartbeat: The medication may slow the heart rate excessively, necessitating a pacemaker in some cases. Certain drugs, such as some hepatitis C treatments, may increase this risk. Seek help if you feel dizzy or faint.

• Heart Devices: Long-term use of amiodarone may affect pacemakers or defibrillators, requiring regular device checkups.

• Pregnancy Risks: Amiodarone may harm unborn babies. Effective birth control is advised during treatment, and a pregnancy test may be required before starting the medication.

• Nerve Problems: Neuropathy, presenting as tingling, numbness, or pain in the legs and feet, can occur and may not resolve after stopping the medication.

Contraindications: Amiodarone should not be used if you have conditions like cardiogenic shock, sick sinus syndrome, second- or third-degree heart block without a pacemaker, a low heart rate without a pacemaker, or a severe iodine allergy. Consult your healthcare provider if any of these apply to you.

In case of an overdose or emergency, seek medical assistance immediately. Always inform your healthcare provider about any other medications or conditions that might interact with amiodarone.

Common side effects:

• nausea
• vomiting
• constipation
• loss of appetite
• general tiredness
• increased sensitivity to sunlight
• tremors
• dizziness
• headaches
• changes in taste or smell
• difficulty sleeping
• lower sex drive
• slight changes in vision

Less common but important to monitor:

• changes in skin color to a blue-gray hue
• hair loss
• low blood pressure
• changes in thyroid function
• unexpected weight changes
• hair thinning
• mood alterations

Serious side effects:

• irregular heartbeat
• severe dizziness
• fainting
• persistent cough
• breathing difficulties
• chest pain
• fever
• jaundice
• abdominal pain
• severe allergic reactions
• rash
• swelling
• difficulty breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Fingolimod
• Bepridil
• Cisapride
• Dronedarone
• Fluconazole
• Grepafloxacin
• Indinavir
• Ketoconazole
• Levomethadyl
• Mesoridazine
• Nelfinavir
• Pimozide
• Piperaquine
• Posaconazole
• Ritonavir
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tipranavir
• Vernakalant
• Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Azole antifungals (such as itraconazole)
• Cimetidine
• Protease inhibitors (such as fosamprenavir, indinavir)
• Rifamycins (such as rifampin)
• St. John's wort
• Clopidogrel
• Statins (Atorvastatin, lovastatin)
• Warfarin
• Dofetilide
• Sotalol
• Macrolide antibiotics (such as clarithromycin, erythromycin)
• Quinolone antibiotics (such as levofloxacin)

Interactions with low risk that usually do not require a change in therapy:

• Atorvastatin
• Rivaroxaban
• Theophylline