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This medication carries several important safety precautions and warnings. Please review the following information carefully and consult your healthcare provider if you have any questions or concerns:

• Pregnancy Warning: This drug can cause serious, potentially fatal harm to an unborn baby. It is crucial to prevent pregnancy while taking it. If you discover you are pregnant, or if you plan to become pregnant, contact your healthcare provider immediately. Discuss reliable birth control methods with your doctor while using this medication.

• Angioedema Risk: Users of ACE inhibitors, such as this medication, may experience angioedema, which is swelling in areas like the face, throat, or tongue. This can be life-threatening if it impairs breathing. The risk is higher for individuals who are Black, older adults, or female. Seek emergency medical attention if you experience any swelling, abdominal pain, or breathing difficulties. If this occurs, discontinue the medication.

• Low Blood Pressure: This medication can cause a significant drop in blood pressure, leading to dizziness, fatigue, or lightheadedness, especially when starting or increasing the dose. Stay hydrated and inform your healthcare provider if you experience extreme dizziness or if you fall. Immediate medical help is needed if you sustain a head injury.

• Kidney Impairment: Although generally beneficial for the kidneys, this medication can sometimes worsen kidney conditions. Those with renal artery stenosis or severe heart failure are at greater risk. Your healthcare provider will monitor your kidney function regularly. Inform them if you notice a decrease in urination.

• High Potassium Levels: This drug may increase potassium levels in the body, which can be dangerous. Those with diabetes, kidney issues, or who take other potassium-raising medications are at higher risk. Report any symptoms like nausea, muscle weakness, or irregular heartbeat to your healthcare provider.

• Liver Concerns: Rarely, this medication can lead to liver problems or failure. Regular liver function tests might be ordered by your provider. If you experience symptoms such as fatigue, stomach pain, or yellowing skin, contact your healthcare provider promptly.

Contraindications:

• Do not use this medication if you have a history of angioedema.
• Avoid concurrent use with aliskiren (Tekturna) if you have high blood sugar.
• Do not take it alongside or within 36 hours of neprilysin inhibitors like Entresto (sacubitril/valsartan).

Please ensure your healthcare provider is aware of your complete medical history and any other medications you are taking before starting this medication.

When taking this medication, you might experience some common side effects, such as dizziness, lightheadedness, tiredness, or headache, as your body adjusts. These effects are generally mild and will often subside over time. A dry cough may also occur. If these symptoms persist or worsen, it’s advisable to consult your healthcare provider. To minimize dizziness and lightheadedness, try getting up slowly from a sitting or lying position.

In some cases, more serious side effects may occur. These include a significant drop in blood pressure, symptoms of a high potassium blood level like muscle weakness or an irregular heartbeat, and signs of kidney issues such as a change in urine output. It’s important to contact your healthcare provider immediately if you notice any of these symptoms. Although rare, severe kidney or liver problems may develop, indicated by symptoms like persistent nausea, loss of appetite, stomach pain, yellowing of the skin or eyes, or dark urine. Immediate medical attention is crucial if such symptoms appear.

A very serious, though rare, allergic reaction called angioedema can occur, characterized by severe swelling of the face, lips, tongue, or throat, and difficulty breathing. If you experience these symptoms, seek emergency medical help without delay. Always report any unusual side effects to your healthcare provider for further guidance.

Lisinopril, also known as Zestril, can interact with several medications and supplements. It's important to inform your healthcare provider about all the medicines and supplements you are taking, including those prescribed, over-the-counter, vitamins, and herbal products. Here are some key interactions:

1. Avoid using with: Aliskiren and Sacubitril. These should not be used with lisinopril as they may cause harmful effects. Your doctor might choose alternative treatments.

2. Caution advised: Some medications, although usually not recommended, may be necessary in certain situations. If prescribed together, your doctor may adjust doses or schedules. These include:

   • Immune system modifiers: Everolimus, Sirolimus, Azathioprine.
   • Potassium-increasing drugs: Losartan, Valsartan, ARBs, Spironolactone, Eplerenone, Amiloride, Triamterene.
   • Others: Lithium, certain diuretics, and birth control pills containing drospirenone.

3. Potential side effects: Combining lisinopril with some medications may heighten side effects. Your doctor will manage doses if both are needed. These include:

   • NSAIDs: Ibuprofen, Naproxen, and similar pain relievers.
   • Others: Aspirin, certain diuretics like Furosemide.

Additionally, a significant reaction could occur if you receive bee or wasp sting allergy shots while taking lisinopril. Ensure all healthcare providers are aware of your lisinopril use to avoid complications. Always consult your doctor or pharmacist for guidance specific to your health needs.